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Methscopolamine
drug data and news
Methscopolamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Methscopolamine | ||
| Brand Names/Synonyms | Ampyrox; Blocan; CHEMBANK1009; CHEMBANK3225; Diopal; Epoxymethamine Bromide; Epoxytropine Tropate Methylbromide; Holopon; Hyoscine Methobromide; Hyoscine Methylbromide; Lescopine Bromide; Mescopil; Methoscopylamine Bromide; Methscopolamine; Methscopolamine Bromide; Methscopolamine Methylbromide; Methylscopolamine Bromide; Methylscopolamine Hydrobromide; N-Methylhyoscine Bromide; N-Methylscopolamine Methylsulfate; N-Methylscopolammonium Bromide; Neo-Avagal; Nutrop; Pamine; Pamine Bromide; Paraspan; Proscomide; Restropin; SCOPOLAMMONIUM, N-METHYLBROMIDE; Scopolamin Methylbromide; Scopolamine Methobromide; Scopolamine Methylbromide; Scopolammonium, N-Methylbromide; Transderm Scop | ||
| Indication | Used as adjunctive therapy for the treatment of peptic ulcer. Also used to treat nausea and vomiting due to motion sickness. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Methscopolamine has many uses including the prevention of motion sickness. It is not clear how Methscopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Methscopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Methscopolamine also may work directly on the vomiting center. Methscopolamine must be taken before the onset of motion sickness to be effective. | ||
| Mechanism Of Action | Methscopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center). | ||
| Methscopolamine News (When available) |
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| Dosage Forms | Tablet (2.5mg, 5mg) | ||
| Drug_Category | Antispasmodics; Anticholinergic Agents; ATC:A03BB03; ATC:S01FA03 | ||
| Absorption | Poorly and unreliably absorbed. Total absorption is 10-25%. | ||
| Interactions |
Interactions for Methscopolamine: Methscopolamine may interact with antidepressants (tricyclic type), MAO inhibitors (e.g., phenelzine, linezolid, tranylcypromine, isocarboxazid, selegiline, furazolidone), quinidine, amantadine, antihistamines (e.g., diphenhydramine), other anticholinergics, potassium chloride supplements, antacids, absorbent-type anti-diarrhea medicines (e.g., kaolin-pectin), phenothiazines (e.g., chlorpromazine, promethazine). | ||
| Toxicity | Symptoms of a methscopolamine overdose include headache; nausea; vomiting; dry mouth; difficulty swallowing; blurred vision; dilated pupils; hot, dry skin; dizziness; drowsiness; confusion; anxiety; seizures; weak pulse; and an irregular heartbeat. In addition, a curare-like action may occur, i.e., neuromuscular blockade leading to muscular weakness and possible paralysis. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | C18H24NO4 | ||
| Molecular Weight | 318.387 g/mol | ||
| Smiles String | C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4)C | ||
| Melting Point | 225 °C | ||
| Water Solubility | Freely soluble | ||
| State | Solid (white odorless crystalline powder) | ||
| LogP/Hphobicity | -2.58 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Little is known about the fate and excretion of methscopolamine. | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Methscopolamine.html http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Methscopolamine | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00314 | ||
| CAS Registry Number | 155-41-9 | ||
| KEGG Compound ID | D00715 | ||
| PubChem ID | SID:65299 | ||
| PharmGKB ID | PA450435 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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