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Methoxsalen
drug data and news
Methoxsalen drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Methoxsalen | ||
| Brand Names/Synonyms | Ammodin; Ammoidin; Meladinin; Meladinine; Meladoxen; Meloxine; Methoxa-Dome; Methoxalen; Methoxaten; Methoxsalen; New-Meladinin; Oxoralen; Oxsoralen; Oxsoralen Lotion; Oxsoralen-Ultra; Oxypsoralen; Proralone-Mop; Psoralen-Mop; Puvalen; Puvamet; Ultra Mop; Ultramop Lotion; Uvadex; Xanthotoxin; Xanthotoxine; Xanthoxin; Zanthotoxin | ||
| Indication | For the treatment of psoriasis and vitiligo | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. | ||
| Mechanism Of Action | after activationm it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. | ||
| Methoxsalen News (When available) |
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| Dosage Forms | LIQUID | ||
| Drug_Category | Antineoplastic Agents; Pigmenting Agents; ATC:D05AD02; ATC:D05BA02 | ||
| Absorption | Not Available | ||
| Interactions | Interactions for Methoxsalen: Concomitant Therapy Special care should be exercised in treating patients who are receiving concomitant therapy (either topically or systemically) with known photosensitizing agents such as anthralin, coal tar or coal tar derivatives, griseofulvin, phenothiazines, nalidixic acid, halogenated salicylanilides (bacteriostatic soaps), sulfonamides, tetracyclines, thiazides, and certain organic staining dyes such as methylene blue, toluidine blue, rose bengal and methyl orange. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | C12H8O4 | ||
| Molecular Weight | 216.19 g/mol | ||
| Smiles String | COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 2.336 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | ~2 hours. | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Methoxsalen.html http://www.rxlist.com/cgi/generic2/methox.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00157 | ||
| CAS Registry Number | 298-81-7 | ||
| KEGG Compound ID | C01864 | ||
| PubChem ID | SID:152480 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 698059 |
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