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Methoxamine
drug data and news
Methoxamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Methoxamine
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| Brand Names/Synonyms |
Methoxamedrine; Methoxamin; Methoxamine; Methoxaminum [Inn-Latin]; Metossamina [Dcit]; Metoxamina [Inn-Spanish]; Pseudomethoxamine; Vasoxine; Vasoxyl |
| Indication |
Indicated for the treatment and management of hypotension. |
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Description |
Not Available |
| Pharmacology |
Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Methoxamine acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels. |
| Mechanism Of Action |
Methoxamine acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). |
Methoxamine News
(When available) |
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| Dosage Forms |
LIQUID |
| Drug_Category |
Vasoconstrictor Agents; Sympathomimetic; ATC:C01CA10 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-amino-1-(2,5-dimethoxyphenyl)-propan-1-ol |
| Chemical Formula |
C11H17NO3 |
| Molecular Weight |
211.258 g/mol |
| Smiles String |
CC(C(C1=C(C=CC(=C1)OC)OC)O)N |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
1.5 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Low |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00062 |
| CAS Registry Number |
390-28-3 |
| KEGG Compound ID |
C07513 |
| PubChem ID |
SID:9716 |
| PharmGKB ID |
PA450431 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
4480
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