|
|
|
|
|
Metharbital
drug data and news
Metharbital drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Metharbital | ||
| Brand Names/Synonyms | AN 23; CHEMBANK2962; Endiemal; Endiemalum; Gemonal; Gemonil; Gemonit; Metabarbital; Metarbital [Inn-Spanish]; Metarbitale [Dcit]; Methabarbital; Methabarbitone; Metharbital; Metharbital [Inn:Jan]; Metharbitalum [Inn-Latin]; Metharbitone; Metharbutal; Methylbarbital; N-Methylbarbital; Sch 412 | ||
| Indication | For the treatment of epilepsy | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Metharbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. | ||
| Mechanism Of Action | Metharbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission. | ||
| Metharbital News (When available) |
| ||
| Dosage Forms | TABLET | ||
| Drug_Category | Anticonvulsants; ATC:N03AA30 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Metharbital: Interactions may occur with the following: adrenocorticoids (cortisone-like medicine), anticoagulants (blood thinners), carbamazepine, corticotropin (barbiturates may decrease the effects of these medicines), central nervous system (CNS) depressants (using these medicines with barbiturates may result in increased CNS depressant effects), divalproex sodium, valproic acid (using these medicines with barbiturates may change the amount of either medicine that you need to take), and oral contraceptives (birth control pills) containing estrogens (barbiturates may decrease the effectiveness of these oral contraceptives, and you may need to change to a different type of birth control). | ||
| Toxicity | Signs of overdose include confusion (severe); decrease in or loss of reflexes; drowsiness (severe); fever; irritability (continuing); low body temperature; poor judgment; shortness of breath or slow or troubled breathing; slow heartbeat; slurred speech; staggering; trouble in sleeping; unusual movements of the eyes; weakness (severe). | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5,5-diethyl-1-methyl-hexahydropyrimidine-2,4,6-trione | ||
| Chemical Formula | C9H14N2O3 | ||
| Molecular Weight | 198.219 g/mol | ||
| Smiles String | CCC1(C(=O)NC(=O)N(C1=O)C)CC | ||
| Melting Point | 150.5 °C | ||
| Water Solubility | 1980 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.051 | ||
| Isoelectric Point | 8.01 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Metharbital.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00757 | ||
| CAS Registry Number | 50-11-3 | ||
| KEGG Compound ID | C12820 | ||
| PubChem ID | SID:583209 | ||
| PharmGKB ID | PA450412 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |