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Methantheline
drug data and news
Methantheline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Methantheline | ||
| Brand Names/Synonyms | Asabaine; Avagal; Banthin; Banthine; Banthine Bromide; CHEMBANK4382; Dixamone Bromide; Doladene; Frenogastrico; Gastrin I; Gastrin-1 Human; Gastron; Gastrosedan; METHANTHELINE; MTB 51; Mantheline; Metantyl; Metaxan; Methanide; Methantheline; Methantheline Bromide; Methanthelinium; Methanthelinium Bromide; Methanthelinum; Methanthine Bromide; Methelina; Resobantin; SC 2910; Ulcine; Ulcudexter; Vagamin; Vagantin; Xanteline | ||
| Indication | For use in the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites. | ||
| Mechanism Of Action | Methantheline inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. | ||
| Methantheline News (When available) |
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| Dosage Forms | TABLET (50 mg) | ||
| Drug_Category | Anticholinergic Agents; Antispasmodics; ATC:A03AB07 | ||
| Absorption | Rapidly absorbed. | ||
| Interactions |
Interactions for Methantheline: This drug may interact with the following: antacids, diarrhea medicine containing kaolin or attapulgite, ketoconazole (using these medicines with an anticholinergic may lessen the effects of the anticholinergic), central nervous system (CNS) depressants (taking scopolamine with CNS depressants may increase the effects of either medicine), other anticholinergics (medicine for abdominal or stomach spasms or cramps), tricyclic antidepressants (taking anticholinergics with tricyclic antidepressants or other anticholinergics may cause an increase in the effects of the anticholinergic), and potassium chloride (using this medicine with an anticholinergic may make gastrointestinal problems caused by potassium worse). | ||
| Toxicity | Symptoms of overdose: blurred vision (continuing) or changes in near vision; clumsiness or unsteadiness; confusion; convulsions; difficulty in breathing, muscle weakness (severe), or tiredness (severe); dizziness; drowsiness (severe); dryness of mouth, nose, or throat (severe); fast heartbeat; fever; hallucinations; slurred speech; unusual excitement, nervousness, restlessness, or irritability; unusual warmth, dryness, and flushing of skin. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | diethyl-methyl-[2-(9H-xanthen-9-ylcarbonyloxy)ethyl]ammonium | ||
| Chemical Formula | C21H26NO3 | ||
| Molecular Weight | 340.436 g/mol | ||
| Smiles String | CC[N+](C)(CC)CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13 | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic, by enzymatic hydrolysis. | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Methantheline.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00751 | ||
| CAS Registry Number | 5818-17-7 | ||
| KEGG Compound ID | C07849 | ||
| PubChem ID | SID:10051 | ||
| PharmGKB ID | PA450408 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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