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Methacycline
drug data and news
Methacycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Methacycline
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| Brand Names/Synonyms |
Metacycline; Methacyclin; Methacycline; Rondomycin |
| Indication |
For the treatment of acute bacterial exacerbations of chronic bronchitis |
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Description |
Not Available |
| Pharmacology |
Methacycline, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Methacycline is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections. |
| Mechanism Of Action |
Methacycline is first metabolized to 14-OH Methacycline. Like other macrolides, it then binds to the 50 S subunit of the 70 S ribosome of the bacteria, blocking RNA-mediated bacterial protein synthesis. Methacycline also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. |
Methacycline News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Anti-bacterial Agents; |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Enteric bacteria and other eubacteria |
| Chemical IUPAC Name |
2-(amino-hydroxy-methylidene)-4-dimethylamino-5,10,11,12a-tetrahydroxy-6-methylidene-4a,5,5a,12a-tetrahydro-4H-tetracene-1,3,12-trione |
| Chemical Formula |
C22H22N2O8 |
| Molecular Weight |
442.419 g/mol |
| Smiles String |
CN(C)C1C2C(C3C(=C)C4=C(C(=CC=C4)O)C(=C3C(=O)C2(C(=O)C(=C(N)O)C1=O)O)O)O |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
-1.164 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00137 |
| CAS Registry Number |
914-00-1 |
| KEGG Compound ID |
C07654 |
| PubChem ID |
SID:9856 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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