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Metaproterenol
drug data and news
Metaproterenol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Metaproterenol | ||
| Brand Names/Synonyms | Alotec; Alupent; CHEMBANK1252; Metaprel; Metaproterenol; Metaproterenol Polistirex; Metaproterenol Polistirex [Usan]; Metaproterenol Sulfate; Novasmasol; ORCIPRENALINE; Orciprenalina [Inn-Spanish]; Orciprenalinum [Inn-Latin]; Prometa | ||
| Indication | For the treatment of Bronchospasm; Chronic bronchitis; Asthma; Emphysema | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Metaproterenol, a synthetic amine, is structurally and pharmacologically similar to isoproterenol. Metaproterenol is used exclusively as a bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, such as Metaproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. | ||
| Mechanism Of Action | Metaproterenol is a moderately selective beta(2)-adrenergic agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of metaproterenol are mediated by cAMP, the production of which is augmented by beta stimulation. The drug is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP. | ||
| Metaproterenol News (When available) |
Breathing Easier Sep 26, 2005 FDA Advisory Committee Jul 14, 2005 FDA Committee To Decide If Azmacort, Alupent, Intal Remain " ... Jul 13, 2005 Changes in Inhaler Devices for Asthma And COPD Jun 19, 2005 | ||
| Dosage Forms | Inhalation | ||
| Drug_Category | Tocolytic Agents; Bronchodilator Agents; ATC:R03AC | ||
| Absorption | 3% (oral bioavailability of 40%) | ||
| Interactions |
-->Interactions for Metaproterenol: Other beta adrenergic aerosol bronchodilators should not be used concomitantly with Alupent® (metaproterenol sulfate USP) because they may have additive effects. Beta adrenergic agonists should be administered with caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, since the action of beta adrenergic agonists on the vascular system may be potentiated.
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| Toxicity | angina, hypertension or hypotension, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise and insomnia. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-[1-hydroxy-2-(1-methylethylamino)ethyl]benzene-1,3-diol | ||
| Chemical Formula | C11H17NO3 | ||
| Molecular Weight | 211.258 g/mol | ||
| Smiles String | CC(C)NCC(C1=CC(=CC(=C1)O)O)O | ||
| Melting Point | 100°C | ||
| Water Solubility | 9.7mg/L | ||
| State | white, crystalline, racemic mixture of two optically active isomers | ||
| LogP/Hphobicity | 1.172 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic and gastric. The major metabolite, metaproterenol-3-0-sulfate, is produced in the gastrointestinal tract. | ||
| Half Life | 6 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Metaproterenol.html http://www.rxlist.com/cgi/generic2/metaproterenol.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00210 | ||
| CAS Registry Number | 586-06-1 | ||
| KEGG Compound ID | C07144 | ||
| PubChem ID | SID:9353 | ||
| PharmGKB ID | PA450390 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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