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Mephenytoin
drug data and news
Mephenytoin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Mephenytoin
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| Brand Names/Synonyms |
Dilantin; Dilantin-125; Epiazin; Epilan; Fenantoin; Gerot-Epilan; Insulton; Mephentoin; Mephenytoin; Mesantoin; Mesdontoin; Mesontoin; Methoin; Methyl Hydantoin; Methylphenetoin; Metydan; NSC-34652; Phenantoin; Phentytoin; Phenylethylmethylhydantoin; Phenytoin; Sacerno; Sedantional; Sedantoin; Sedantoinal; Triantoin |
| Indication |
For the treatment of refractory partial epilepsy |
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Description |
Not Available |
| Pharmacology |
Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, Mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures. |
| Mechanism Of Action |
The mechanism of action of Mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials. |
Mephenytoin News
(When available) |
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| Dosage Forms |
Tablet |
| Drug_Category |
Anticonvulsants; ATC:N03AB04 |
| Absorption |
Not Available |
| Interactions |
Drug Interactions:
Some anticonvulsants may interact with Mephenytoin. They can either increase or
decrease the effect of Mephenytoin. Those anticonvulsants include divalproex sodium, valproic acid, and
phenobarbital.
Mephenytoin may also affect the effects of other drugs, which include some steroid medications,
warfarin, certain heart medicines, birth control pills, anti-infective medicines, furosemide and theophylline
Please note that Mephenytoin may interact with other drugs that are not listed here.
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| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione |
| Chemical Formula |
C12H14N2O2 |
| Molecular Weight |
218.252 g/mol |
| Smiles String |
CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2 |
| Melting Point |
135 °C |
| Water Solubility |
1270 mg/L |
| State |
Solid |
| LogP/Hphobicity |
1.515 |
| Isoelectric Point |
8.51 |
| Biotransformation |
Not Available |
| Half Life |
~7 hours |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Mephenytoin.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00512 |
| CAS Registry Number |
50-12-4 |
| KEGG Compound ID |
C07135 |
| PubChem ID |
SID:148526 |
| PharmGKB ID |
PA450373 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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