|
![]() |
|
|
Melatonin
drug data and news
Melatonin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Melatonin | ||
| Brand Names/Synonyms | Circadin; MT6; Mela-T; Melatol; Melatonex; Melatonin; Melatonine; Melovine; Night Rest; Regulin | ||
| Indication | For the treatment of insomnia and jet lag | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Melatonin is a hormone normally produced in the pineal gland and released into the blood. The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. It helps regulate sleep-wake cycles or the circadian rhythm. Production of melatonin is stimulated by darkness and inhibited by light. High levels of melatonin induce sleep and so consumption of the drug can be used to combat insomnia and jet lag. | ||
| Mechanism Of Action | Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate. | ||
| Melatonin News (When available) |
Drink Healthy To Stay Healthy: Tart Cherry Juice Gaining ... 07 Mar 2006 The Sub-Fertile Stallion 07 Mar 2006 Melatonin Pills May Help Ease Tinnitus Feb 24, 2006 Melatonin could help tinnitus, improve sleep Feb 23, 2006 Review shows melatonin helps seniors sleep well Feb 21, 2006 Alternatives: Evidence Is Slight for Melatonin as Sleeping Aid Feb 20, 2006 No evidence that melatonin is effective in treating secondary ... Feb 19, 2006 Melatonin may not be all it's cracked up to be Feb 26, 2006 Melatonin a Bust for Jet Lag or Shift-Work Sleep Problems Feb 10, 2006 Melatonin May Not Always Bring Sleep Feb 10, 2006 Melatonin doesn't help catch extra ZZZ's: study Feb 10, 2006 No evidence melatonin relieves jet lag -scientists Feb 9, 2006 Melatonin Doesn't Prevent Jet Lag, Sleep Disorders (Update1) Feb 10, 2006 Melatonin for Treatment of Sleep Disorders Feb 10, 2006 No evidence melatonin relieves jet lag -scientists Feb 9, 2006 Melatonin may not help sleep disorders? Feb 11, 2006 ‘No evidence’ that melatonin helps with jet lag Feb 13, 2006 Melatonin Tablets Won't Help You Sleep Feb 13, 2006 Melatonin useless when it comes to sorting out sleep disorders Feb 12, 2006 No evidence melatonin relieves jet lag Feb 10, 2006 Melatonin for Travelers' Sleep Woes? Feb 9, 2006 Melatonin Not Seen To Prevent Jet Lag Feb 10, 2006 Study: Melatonin Does Not Help With Jet Lag Feb 10, 2006 Melatonin Associated with Allev Iating Tinnitus Symptoms, Better ... Feb 22, 2006 Melatonin for Tinnitus and Steroids to Ease Tonsillectomy Pain Feb 22, 2006 Two Natural Products, EGCG from Green Tea and Melatonin, Work ... Feb 21, 2006 Decreased Melatonin Production Linked to Light Exposure Feb 10, 2006 Is your clock slow or fast? Mar 3, 2006 Melatonin may cut hypertension Feb 2, 2006 Health Briefs Feb 27, 2006 Study: Working the night shift increases breast cancer risk Mar 2, 2006 Mother’s Glasses that Block Blue Light Provide Sleep Hormones ... Feb 20, 2006 Seeing the light Mar 2, 2006 Study: Light May Affect Breast Cancer Risk Mar 2, 2006 Insomnia: How To Get A Good Night’s Sleep Naturally Mar 5, 2006 Red grapefruit earns a star on cholesterol test Feb 22, 2006 Thursday, March 2, 2006, 4:42 pm Mar 2, 2006 Cloudy weather got you down? Feb 26, 2006 Scott Parks on education Feb 28, 2006 New claim over jet lag prevention Feb 12, 2006 Don't let spring fever infect kids' grades Feb 28, 2006 Hormone therapy not cure for sleep disorders Feb 10, 2006 Doctor’s Q&A Feb 26, 2006 Beware Bogus Claims by HGH Spray Internet Marketers: Dr. Ron Klatz ... Mar 4, 2006 Exposure To Light May Increase Breast Cancer Risk Feb 14, 2006 Medical Minute Feb 12, 2006 QUICK STUDY : A weekly digest of new research on major health ... Feb 20, 2006 | ||
| Dosage Forms | CAPSULE, LIQUID, LOZENGE, TABLET | ||
| Drug_Category | Free Radical Scavengers; Antioxidants; Anticonvulsants; Adjuvants, Immunologic; ATC:N05CM17 | ||
| Absorption | The absorption and bioavailability of melatonin varies widely. | ||
| Interactions |
Interactions for Melatonin: Melatonin may interact with the following drugs: aspirin and other NSAIDs (may lower melatonin levels), fluvoxamine (bioavailability of oral melatonin is increased with coadministration), beta blockers (may decrease melatonin levels), fluoxetine (reports of psychotic episodes when coadministered), progestin (coadministration of melatonin with progestin can inhibit ovarian function in women), benzodiazepenes and other sedating drugs (may result in additive sedation and an increased incidence of adverse effects), and corticosteroids (coadministration of melatonin and corticosteroids may interfere with the efficacy of the corticosteroids). | ||
| Toxicity | Oral, rat: LD50 = >3200 mg/kg | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ethanamide | ||
| Chemical Formula | C13H16N2O2 | ||
| Molecular Weight | 232.278 g/mol | ||
| Smiles String | CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC | ||
| Melting Point | 117 °C | ||
| Water Solubility | Not Available | ||
| State | Solid (pale yellow leaflets) | ||
| LogP/Hphobicity | 1.536 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic. Metabolized in the liver by hydroxylation to 6-hydroxymelatonin. | ||
| Half Life | 35 to 50 minutes | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/MTM/melatonin.html http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/mel_0286.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00742 | ||
| CAS Registry Number | 73-31-4 | ||
| KEGG Compound ID | C01598 | ||
| PubChem ID | SID:149246 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 793167 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |