Melatonin drug data and news

Melatonin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Melatonin
Brand Names/Synonyms Circadin; MT6; Mela-T; Melatol; Melatonex; Melatonin; Melatonine; Melovine; Night Rest; Regulin
Indication For the treatment of insomnia and jet lag
Sponsored links
Description Not Available
Pharmacology Melatonin is a hormone normally produced in the pineal gland and released into the blood. The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. It helps regulate sleep-wake cycles or the circadian rhythm. Production of melatonin is stimulated by darkness and inhibited by light. High levels of melatonin induce sleep and so consumption of the drug can be used to combat insomnia and jet lag.
Mechanism Of Action Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate.
Melatonin News
(When available)

Drink Healthy To Stay Healthy: Tart Cherry Juice Gaining ...  07 Mar 2006
Some of the antioxidants found in Tart Is Smart tart cherry juice are, anthocyanins, melatonin and super oxide dismutase (SOD)(4). ... - U.S. Newswire (press release),

The Sub-Fertile Stallion  07 Mar 2006
When days are short the pineal gland within the brain releases melatonin which it is believed inhibits the hypothalamus from releasing GnRH. ... - TheHorse.com,

Melatonin Pills May Help Ease Tinnitus  Feb 24, 2006
Melatonin is a hormone made in the brain's pineal gland. Natural melatonin helps regulate cycles of sleep and wakefulness. Levels ... - WebMD

Melatonin could help tinnitus, improve sleep  Feb 23, 2006
2/23/2006 - A daily supplement of melatonin could improve tinnitus and sleep, a result that offers hope to the estimated 15m Americans who consider their ... - NutraIngredients-usa.com,

Review shows melatonin helps seniors sleep well  Feb 21, 2006
Naturalproductsinsider.com looks at recent research that demonstrates how melatonin can benefit the health of the elderly by maximizing their sleep efficiency. ... - Newstarget.com,

Alternatives: Evidence Is Slight for Melatonin as Sleeping Aid  Feb 20, 2006
Although melatonin is widely used as a sleep aid, a review of the research says there is little evidence that it works, either for jet lag, shift work or sleep ... - New York Times,

No evidence that melatonin is effective in treating secondary ...  Feb 19, 2006
There is no evidence that melatonin is effective in treating secondary sleep disorders or preventing jet lag, finds a study published online by the British ... - News-Medical.net,

Melatonin may not be all it's cracked up to be  Feb 26, 2006
Supplements of the hormone melatonin — thought to be involved in regulating the body's daily rhythm — are often touted to ameliorate such sleeping problems ... - Austin American-Statesman (subscription),

Melatonin a Bust for Jet Lag or Shift-Work Sleep Problems  Feb 10, 2006
10 - A Canadian group has issued a wake up alert on melatonin, the circadian-rhythm hormone that has been touted as the cure-all for jet leg. It doesn't work. ... - CNN

Melatonin May Not Always Bring Sleep  Feb 10, 2006
10 (HealthDay News) -- Melatonin, the widely used over-the-counter hormone supplement, isn't effective as a sleeping pill if your insomnia is caused by an ... - Forbes

Melatonin doesn't help catch extra ZZZ's: study  Feb 10, 2006
There's no evidence melatonin supplements help people overcome sleep disorders like jet lag, says a new study from the University of Alberta. ... - CBC News,

No evidence melatonin relieves jet lag -scientists  Feb 9, 2006
LONDON (Reuters) - Melatonin is described as a natural nightcap but researchers said on Friday there is no scientific evidence that it relieves jet lag. ... - Reuters

Melatonin Doesn't Prevent Jet Lag, Sleep Disorders (Update1)  Feb 10, 2006
Feb. 10 (Bloomberg) -- Melatonin, a treatment commonly used for insomnia and jet lag, doesn't help people fall asleep or sleep better, a study in the British ... - Bloomberg

Melatonin for Treatment of Sleep Disorders  Feb 10, 2006
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that is primarily produced by the pineal gland, located behind the third ventricle in the brain.4 In ... - Food Consumer,

No evidence melatonin relieves jet lag -scientists  Feb 9, 2006
Feb 9, 2006 — LONDON (Reuters) - Melatonin is described as a natural nightcap but researchers said on Friday there is no scientific evidence that it relieves ... - ABC News

Melatonin may not help sleep disorders?  Feb 11, 2006
By fc. Researchers say melatonin is ineffective in treating insomnia caused by an underlying condition or preventing jet lag. The study, appearing in the Feb. ... - Food Consumer,

‘No evidence’ that melatonin helps with jet lag  Feb 13, 2006
2/13/2006 - A review of 25 studies has led researchers to claim the human hormone melatonin does not help people with sleep problems like jet lag, conclusions ... - NutraIngredients-usa.com,

Melatonin Tablets Won't Help You Sleep  Feb 13, 2006
Melatonin is not effective for treating sleep problems, finds a review of the evidence, published today. Sleep disorders, either ... - StaffNurse.com,

Melatonin useless when it comes to sorting out sleep disorders  Feb 12, 2006
According to Canadian scientists there is no evidence to support the belief that melatonin has any effect in the treatment of sleep disorders. ... - News-Medical.net,

No evidence melatonin relieves jet lag  Feb 10, 2006
There is no evidence that melatonin is effective in treating secondary sleep disorders or preventing jet lag, Canadian research has found. ... - 999 Today,

Melatonin for Travelers' Sleep Woes?  Feb 9, 2006
Feb. 9, 2006 -- Melatonin supplements may not ease sleep woes caused by jet lag, shift work, or health problems, according to a new study. ... - WebMD

Melatonin Not Seen To Prevent Jet Lag  Feb 10, 2006
According to an article published in the British Medical Journal, there seems to be no evidence that melatonin helps treat secondary sleep disorders or ... - Medical News Today,

Study: Melatonin Does Not Help With Jet Lag  Feb 10, 2006
London, England (AHN) - Over-the-counter hormone supplement Melatonin is commonly used as a sleep aid. However, a new study suggests ... - All Headline News

Melatonin Associated with Allev Iating Tinnitus Symptoms, Better ...  Feb 22, 2006
A new study asserts that melatonin use is associated with improvement of tinnitus and sleep. Melatonin is a hormone produced by ... - Newswise (press release)

Melatonin for Tinnitus and Steroids to Ease Tonsillectomy Pain  Feb 22, 2006
5. “The Effects of Melatonin on Tinnitus and Sleep.� A new research effort concludes that melatonin use is associated with improvement of tinnitus and sleep ... - Newswise (press release)

Two Natural Products, EGCG from Green Tea and Melatonin, Work ...  Feb 21, 2006
EGCG and melatonin synergistically block the activities of the HIV viral NEF and Vpr proteins, thereby restoring immunity against the virus. ... - PR Web (press release),

Decreased Melatonin Production Linked to Light Exposure  Feb 10, 2006
Editor's note: Production of melatonin, a hormone involved in sleep disorders, can be affected by many factors such as age and exposure to light. ... - Food Consumer,

Is your clock slow or fast?  Mar 3, 2006
...circadian rhythms to a certain degree. The three ways we can do this involve sleep, melatonin, and light. Sleep: ‘If you are going ... - Saga Health News,

Melatonin may cut hypertension  Feb 2, 2006
02/02/2006 - Melatonin, a naturally occurring hormone that can be taken orally to regulate sleep patterns, reduced the blood pressure (BP) of hypertensive women ... - NutraIngredients.com,

Health Briefs  Feb 27, 2006
Although melatonin is widely used as a sleep aid, a review of the research says there is little evidence that it works, either for jet lag, shift work or sleep ... - Winston-Salem Journal,

Study: Working the night shift increases breast cancer risk  Mar 2, 2006
That's when a small gland deep in the brain produces melatonin. ... What about taking melatonin supplements which are sold over the counter? ... - WIS,

Mother’s Glasses that Block Blue Light Provide Sleep Hormones ...  Feb 20, 2006
Melatonin, the sleep hormone, appears in breast milk in proportion to the amount in the mother’s blood. Exposing the eyes to the ... - PR Web (press release),

Seeing the light  Mar 2, 2006
That's when our bodies produce melatonin. ... Sleeping with the TV or light on, or working at your computer late at night can also turn off melatonin. ... - WHDH-TV,

Study: Light May Affect Breast Cancer Risk  Mar 2, 2006
They said a small gland deep in the brain produces melatonin, but exposing eyes to light turns off production of melatonin, which is a hormone that appears to ... - WBAL Channel.com,

Insomnia: How To Get A Good Night’s Sleep Naturally  Mar 5, 2006
...body and muscles. Melatonin is a hormone that helps our bodies regulate our sleep cycles and promotes sound sleep. Chamomile, hops ... - eMaxHealth.com,

Red grapefruit earns a star on cholesterol test  Feb 22, 2006
EVIDENCE IS SLIGHT FOR MELATONIN AS SLEEPING AID Although melatonin is widely used as a sleep aid, a review of the research says there is little evidence that ... - International Herald Tribune,

Thursday, March 2, 2006, 4:42 pm  Mar 2, 2006
Darkness allows the brain to produce melatonin, a hormone that appears to offer protection against cancer cells. But when the eyes ... - NBC5.com,

Cloudy weather got you down?  Feb 26, 2006
...greater effect. Melatonin, a hormone produced by the pineal gland within your brain, may be a culprit in the winter blues. We see ... - Summit Daily News,

Scott Parks on education  Feb 28, 2006
He found research about teens and their levels of melatonin, the hormone that promotes sleep. The research shows that melatonin ... - Dallas Morning News (subscription),

New claim over jet lag prevention  Feb 12, 2006
There is no evidence the hormone melatonin is effective in preventing jet lag or treating sleep disorders, research has found. Melatonin ... - Trade Arabia,

Don't let spring fever infect kids' grades  Feb 28, 2006
John's Eastwood Clinic. According to Wenig, in the winter our brains increase the production of melatonin, which makes us sleepier and more docile. ... - DetNews.com,

Hormone therapy not cure for sleep disorders  Feb 10, 2006
LIFE STYLE EXTRA (UK) - Hormone therapy melatonin is is not an effective remedy for sleep disorders such as jet lag, according to new research. ... - Life Style Extra,

Doctor’s Q&A  Feb 26, 2006
...to hospital. QI have heard of people taking melatonin to help jet lag and they say it works well. Does it help insomnia? My doctor ... - The Herald,

Beware Bogus Claims by HGH Spray Internet Marketers: Dr. Ron Klatz ...  Mar 4, 2006
Because HGH sets the pace for all the other anti-aging hormones such as estrogen, testosterone, DHEA, and melatonin, there has been an increasing interest in ... - PR Web (press release),

Exposure To Light May Increase Breast Cancer Risk  Feb 14, 2006
In the dark, a small gland deep in the brain produces melatonin. Exposing your eyes to light turns off production of melatonin, which ... - NBC6.net,

Medical Minute  Feb 12, 2006
February 12, 2006 - When it comes to helping you get your zee's, the so-called sleep-inducer melatonin gets an "F". Thousands of ... - 13abc.com,

QUICK STUDY : A weekly digest of new research on major health ...  Feb 20, 2006
Might this be ameliorated by supplements of the hormone melatonin -- thought to be involved in regulating the body's daily rhythm? ... - Washington Post,

Dosage Forms CAPSULE, LIQUID, LOZENGE, TABLET
Drug_Category Free Radical Scavengers; Antioxidants; Anticonvulsants; Adjuvants, Immunologic; ATC:N05CM17
Absorption The absorption and bioavailability of melatonin varies widely.
Interactions Interactions for Melatonin:
Melatonin may interact with the following drugs: aspirin and other NSAIDs (may lower melatonin levels), fluvoxamine (bioavailability of oral melatonin is increased with coadministration), beta blockers (may decrease melatonin levels), fluoxetine (reports of psychotic episodes when coadministered), progestin (coadministration of melatonin with progestin can inhibit ovarian function in women), benzodiazepenes and other sedating drugs (may result in additive sedation and an increased incidence of adverse effects), and corticosteroids (coadministration of melatonin and corticosteroids may interfere with the efficacy of the corticosteroids).
Toxicity Oral, rat: LD50 = >3200 mg/kg
Organisms Affected Humans and other mammals
Chemical IUPAC Name N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ethanamide
Chemical Formula C13H16N2O2
Molecular Weight 232.278 g/mol
Smiles String CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
Melting Point 117 °C
Water Solubility Not Available
State Solid (pale yellow leaflets)
LogP/Hphobicity 1.536
Isoelectric Point Not Available
Biotransformation Hepatic. Metabolized in the liver by hydroxylation to 6-hydroxymelatonin.
Half Life 35 to 50 minutes
Protein Binding [%] Not Available
RxList Link Not Available>RXlist
Sponsored links
Drug Reference http://www.drugs.com/MTM/melatonin.html
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/mel_0286.shtml
Drug Type Approved Drug
Accession No APRD00742
CAS Registry Number 73-31-4
KEGG Compound ID C01598
PubChem ID SID:149246
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 793167

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