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Meclizine
drug data and news
Meclizine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Meclizine | ||
| Brand Names/Synonyms | Ancolan; Ancolon; Antivert; Antivert/25; Antivert/50; Bonadettes; Bonadoxin; Bonamine; Bonine; Calmonal; Chiclida; Diadril; Dramamine; Dramamine Ii; Histamethine; Histamethizine; Histametizine; Histametizyne; Itinerol; Longifene; Marex; Meclicot; Meclizine; Meclizine Hcl; Meclozine; Medivert; Monamine; Navicalm; Neo-Istafene; Neo-Suprimal; Neo-Suprimel; Parachloramine; Peremesin; Postafen; Postafene; Ravelon; Sabari; Sea-Legs; Siguran; Subari; Suprimal; Travelon; U. C. B. 5062; UCB 170; UCB 5052; UCB 5062; Veritab; Vibazine; Vomisseis; Vomissels | ||
| Indication | For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus. | ||
| Mechanism Of Action | Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone. | ||
| Meclizine News (When available) |
Renewed wet pattern will stick around Mar 2, 2006 When Worlds Collide Feb 22, 2006 A crash course in cruising Jan 22, 2006 When choosing cruise line, learn to navigate info seas Jan 22, 2006 Cruise season is peaking Jan 22, 2006 Claudication may require surgery Nov 29, 2005 Trial begins against drug manager Nov 10, 2005 Ramsay Hunt Syndrome Types I and II Sep 1, 2005 Fluoxetine for Vestibular Dysfunction and Anxiety: A Prospective ... Jul 6, 2005 Ramsay Hunt Syndrome Types I and II Jul 6, 2005 Fluoxetine for Vestibular Dysfunction and Anxiety: A Prospective ... Jul 6, 2005 Ramsay Hunt Syndrome Types I and II Jul 6, 2005 DEAR PHARMACIST Jun 28, 2005 Not Your "Typical Patient": Cryptococcal Meningitis in an ... Jun 11, 2005 Ask the Pharmacist: Picking some of the top over-the-counter ... Jun 21, 2005 Ask the Pharmacist: Picking some of the top over-the-counter ... Jun 21, 2005 Not Your "Typical Patient": Cryptococcal Meningitis in an ... Jun 11, 2005 DR. HOOK- Shove boat: Patching together a cure Jun 9, 2005 Symptoms of Vertigo Apr 4, 2005 Make your ride dizzy-free Apr 5, 2005 Ramsay Hunt Syndrome Types I and II Apr 8, 2005 Ramsay Hunt Syndrome Types I and II 08 Apr 2005 Symptoms of Vertigo Apr 4, 2005 Make your ride dizzy-free Apr 5, 2005 | ||
| Dosage Forms | Tablets | ||
| Drug_Category | Anti-allergic Agents; Antiemetics; Antihistamines; | ||
| Absorption | Well absorbed | ||
| Interactions |
Interactions for Meclizine: No information provided. | ||
| Toxicity | Drowsiness, anticholinergic effects, LD50=mg/kg (orally in rat) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 1-[(4-chlorophenyl)-phenyl-methyl]-4-[(3-methylphenyl)methyl]piperazine | ||
| Chemical Formula | C25H27ClN2 | ||
| Molecular Weight | 390.948 g/mol | ||
| Smiles String | CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl | ||
| Melting Point | Not Available | ||
| Water Solubility | 0.1gm/100ml | ||
| State | Solid | ||
| LogP/Hphobicity | 5.966 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 6 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Meclizine.html http://www.rxlist.com/cgi/generic/mecliz.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00354 | ||
| CAS Registry Number | 569-65-3 | ||
| KEGG Compound ID | C07116 | ||
| PubChem ID | SID:355431 | ||
| PharmGKB ID | PA450338 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 220442 |
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