Meclizine drug data and news

Meclizine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Meclizine
Brand Names/Synonyms Ancolan; Ancolon; Antivert; Antivert/25; Antivert/50; Bonadettes; Bonadoxin; Bonamine; Bonine; Calmonal; Chiclida; Diadril; Dramamine; Dramamine Ii; Histamethine; Histamethizine; Histametizine; Histametizyne; Itinerol; Longifene; Marex; Meclicot; Meclizine; Meclizine Hcl; Meclozine; Medivert; Monamine; Navicalm; Neo-Istafene; Neo-Suprimal; Neo-Suprimel; Parachloramine; Peremesin; Postafen; Postafene; Ravelon; Sabari; Sea-Legs; Siguran; Subari; Suprimal; Travelon; U. C. B. 5062; UCB 170; UCB 5052; UCB 5062; Veritab; Vibazine; Vomisseis; Vomissels
Indication For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness
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Description Not Available
Pharmacology Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Mechanism Of Action Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Meclizine News
(When available)

Renewed wet pattern will stick around  Mar 2, 2006
...flying between SFO and Calgary, in spite of inflicting permanent damage to severely cramped passengers like himself, gulped a double dose of meclizine in order ... - St. Helena Star,

When Worlds Collide  Feb 22, 2006
...home. The Martins say that after five months of treatment on meclizine, an antivertigo drug, their son is showing improvement. Mrs ... - LongIslandPress.com,

A crash course in cruising  Jan 22, 2006
Bonine is just as effective and keeps you awake to enjoy some of that night life. Bonine also comes in a generic form called Meclizine NCL that is cheaper. ... - Indianapolis Star,

When choosing cruise line, learn to navigate info seas  Jan 22, 2006
Bonine is just as effective and keeps you awake to enjoy some of that nightlife. Bonine also comes in a generic form called meclizine that is cheaper. ... - Jackson Clarion Ledger,

Cruise season is peaking  Jan 22, 2006
...make you drowsy. Bonine is just as effective and it comes in a generic form called Meclizine NCL that is cheaper. If you prefer ... - Cincinnati Enquirer,

Claudication may require surgery  Nov 29, 2005
...up. Dear Dr. Gott: My doctor prescribed meclizine for an 11-week bout of vertigo and Amoxil for an ear infection that followed. An ... - The Spokesman Review,

Trial begins against drug manager  Nov 10, 2005
His chart showed markups of specific drugs, including a 2,200 percent markup for a generic motion sickness tablet called meclizine hydrochloride and a 300 ... - Cincinnati Enquirer,

Ramsay Hunt Syndrome Types I and II  Sep 1, 2005
Corticosteroids such as prednisone may be used, and scopolamine or antihistamines such as meclizine (Antivert) will reduce vertigo and tinnitus. ... - rarediseases.about.com

Fluoxetine for Vestibular Dysfunction and Anxiety: A Prospective ...  Jul 6, 2005
Medications such as meclizine may provide some initial relief but mask the ability of the central nervous system to compensate for the vestibular loss. ... - Psychosomatics (subscription)

Ramsay Hunt Syndrome Types I and II  Jul 6, 2005
Corticosteroids such as prednisone may be used, and scopolamine or antihistamines such as meclizine (Antivert) will reduce vertigo and tinnitus. ... - rarediseases.about.com <**results**>

Fluoxetine for Vestibular Dysfunction and Anxiety: A Prospective ...  Jul 6, 2005
Medications such as meclizine may provide some initial relief but mask the ability of the central nervous system to compensate for the vestibular loss. ... - Psychosomatics (subscription)

Ramsay Hunt Syndrome Types I and II  Jul 6, 2005
Corticosteroids such as prednisone may be used, and scopolamine or antihistamines such as meclizine (Antivert) will reduce vertigo and tinnitus. ... - rarediseases.about.com

DEAR PHARMACIST  Jun 28, 2005
...application to the scalp. MOTION SICKNESS: Bonine or Dramamine, look for active ingredient meclizine. COLD: Zicam medicated swabs ... - Newsday

Not Your "Typical Patient": Cryptococcal Meningitis in an ...  Jun 11, 2005
...included a high- protein, high-calorie diet, dietician consultations, supplemental nutritional support, nausea medications such as meclizine 25 mg by mouth ... - RedNova.com

Ask the Pharmacist: Picking some of the top over-the-counter ...  Jun 21, 2005
...important. RID Home Lice Control Spray is good. — Motion sickness: Bonine or Dramamine, look for active ingredient meclizine. — Cold ... - Marconews (subscription),

Ask the Pharmacist: Picking some of the top over-the-counter ...  Jun 21, 2005
...important. RID Home Lice Control Spray is good. — Motion sickness: Bonine or Dramamine, look for active ingredient meclizine. — Cold ... - Marconews (subscription),

Not Your "Typical Patient": Cryptococcal Meningitis in an ...  Jun 11, 2005
...included a high- protein, high-calorie diet, dietician consultations, supplemental nutritional support, nausea medications such as meclizine 25 mg by mouth ... - RedNova.com,

DR. HOOK- Shove boat: Patching together a cure  Jun 9, 2005
There are other medicines for motion sickness, but they tend to be too sedating. Once I took Antivert (meclizine) in Maine when I went whale-watching. ... - The Hook,

Symptoms of Vertigo  Apr 4, 2005
There are many drugs that will relieve a mild case of vertigo including perphenazine, scopolamine, meclizine and dimenhydrinate. ... - Khalsa News Network

Make your ride dizzy-free  Apr 5, 2005
Take an over-the-counter antihistamine such as dimenhydrinate (Dramamine), meclizine (Antivert or Bonine) or diphenhydramine (Benadryl) before feeling sick. ... - Press-Enterprise (subscription)

Ramsay Hunt Syndrome Types I and II  Apr 8, 2005
Corticosteroids such as prednisone may be used, and scopolamine or antihistamines such as meclizine (Antivert) will reduce vertigo and tinnitus. ... - rarediseases.about.com

Ramsay Hunt Syndrome Types I and II  08 Apr 2005
Corticosteroids such as prednisone may be used, and scopolamine or antihistamines such as meclizine (Antivert) will reduce vertigo and tinnitus. ... - rarediseases.about.com

Symptoms of Vertigo  Apr 4, 2005
There are many drugs that will relieve a mild case of vertigo including perphenazine, scopolamine, meclizine and dimenhydrinate. ... - Khalsa News Network,

Make your ride dizzy-free  Apr 5, 2005
Take an over-the-counter antihistamine such as dimenhydrinate (Dramamine), meclizine (Antivert or Bonine) or diphenhydramine (Benadryl) before feeling sick. ... - Press-Enterprise (subscription),

Dosage Forms Tablets
Drug_Category Anti-allergic Agents; Antiemetics; Antihistamines;
Absorption Well absorbed
Interactions Interactions for Meclizine:

No information provided.

Toxicity Drowsiness, anticholinergic effects, LD50=mg/kg (orally in rat)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 1-[(4-chlorophenyl)-phenyl-methyl]-4-[(3-methylphenyl)methyl]piperazine
Chemical Formula C25H27ClN2
Molecular Weight 390.948 g/mol
Smiles String CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
Melting Point Not Available
Water Solubility 0.1gm/100ml
State Solid
LogP/Hphobicity 5.966
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 6 hours
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Meclizine.html
http://www.rxlist.com/cgi/generic/mecliz.htm
Drug Type Approved Drug
Accession No APRD00354
CAS Registry Number 569-65-3
KEGG Compound ID C07116
PubChem ID SID:355431
PharmGKB ID PA450338
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 220442

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