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Marimastat
drug data and news
Marimastat drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Marimastat
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| Brand Names/Synonyms |
BB 2516; BB 2516;; BB-2516; Marimastat; Marimastat [Usan] |
| Indication |
For the treatment of various cancers |
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Description |
Not Available |
| Pharmacology |
Used in the treatment of cancer, it is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes. |
| Mechanism Of Action |
Marimastat is a hydroxamic acid, matrix metalloprotease inhibitor. It mimics the peptide structure of natural MMP substrates. It binds to matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) thereby preventing the degradation of the basement membrane by these proteases. This antiprotease action prevents the migration of endothelial cells needed to form new blood vessels. Inhibition of MMPs also prevents the entry and exit of tymor cells into existing blood cells, thereby preventing metastasis. |
Marimastat News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Antineoplastic Agents; ATC:L01X |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
N-[2,2-dimethyl-1-(methylcarbamoyl)propyl]-2-[hydroxy-(hydroxycarbamoyl)methyl]-4-methyl-pentanamide |
| Chemical Formula |
C15H29N3O5 |
| Molecular Weight |
331.408 g/mol |
| Smiles String |
CC(C)CC(C(C(=O)NO)O)C(=O)NC(C(=O)NC)C(C)(C)C |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
0.607 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00559 |
| CAS Registry Number |
154039-60-8 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:695683 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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