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Lymecycline
drug data and news
Lymecycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Lymecycline
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| Brand Names/Synonyms |
AUREOMYCIN; Acronize; Acronize Pd; Aureocarmyl; Aureociclin; Aureociclina; Aureocina; Aureocycline; Aureomicina; Aureomycin Hydrochloride; Aureomycin Monohydrochloride; Aureomycin a-377; Aureomykoin; Aurofac; Aurofac 10; Auxeomycin; B-Aureo; Biomitsin; Biomitsin Hydrochloride; Biomycin; Biomycin A; Biomycin Hydrochloride; Biovetin; C4881; CHEMBANK901; CLTC; CTC; Centraureo; Chlorotetracycline; Chlorotetracycline Hydrochloride; Chlortetracyclin; Chlortetracycline; Chlortetracycline Hydrochloride; Chlortetracyclinium Chloride; Chrusomykine; Chrysomykine; Clorocipan; Duomycin; Flamycin; Isphamycin; Lymecycline; Orospray; Psittacin Hydrochloride; Tetra 5; Tetralysal; Tocopherex; U-6780 |
| Indication |
For the treatment of bacterial infection including: Brucellosis; Mycoplasma infection; Trachoma; Chronic bronchitis; Acne vulgaris; Chlamydial infection |
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Description |
Not Available |
| Pharmacology |
Lymecycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Lymecycline inhibits cell growth by inhibiting translation. |
| Mechanism Of Action |
Lymecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Lymecycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Cells become resistant to Lymecycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Lymecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Lymecycline from acting on the ribosome. |
Lymecycline News
(When available) |
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| Dosage Forms |
Capsule |
| Drug_Category |
Antiprotozoals; Anti-bacterial Agents; ATC:J01AA04 |
| Absorption |
Not Available |
| Interactions |
Drug Interactions:
The absorption of lymecycline may be affected by the simultaneous administration of
indigestion remedies, iron or zinc supplements.
Oral contraceptives may be less effective while you are taking lymecycline.
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| Toxicity |
Not Available |
| Organisms Affected |
Enteric bacteria and other eubacteria |
| Chemical IUPAC Name |
2-(amino-hydroxy-methylidene)-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione |
| Chemical Formula |
C22H23ClN2O8 |
| Molecular Weight |
478.879 g/mol |
| Smiles String |
CC1(C2CC3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)N(C)C)O |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
0.315 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00565 |
| CAS Registry Number |
992-21-2 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:605300 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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