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Lutropin alfa
drug data and news
Lutropin alfa drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Lutropin alfa
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| Brand Names/Synonyms |
Lutropin beta chain precursor;Luteinizing hormone beta subunit;LSH- beta;LSH-B;LH-B; Luveris (Serono) |
| Indication |
For treatment of female infertility |
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Description |
Recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues |
| Pharmacology |
Used to facilitate female conception, lutropin alfa performs the same actions as luteinizing hormone (LH), which is normally produced in the pituitary gland. Lutropin is usually given in combination with follitropin alfa. In females, a LH surge about halfway through the menstrual cycle triggers the onset of ovulation. LH also induces the ovulated follicle to become a corpus luteum, which then secretes progesterone. |
| Mechanism Of Action |
Binds to the luteinizing hormone receptor which then activates adenylate cylcase through G protein mediation. Adenylate cyclase then activates many other pathways leading to steroid hormone production and other follicle maturation processes. |
Lutropin alfa News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Fertility Agents |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Human luteinizing hormone |
| Chemical Formula |
C1014H1609N287O294S27 >BetaChain (LH) |
| Molecular Weight |
23390.3 |
| Smiles String |
Not Available |
| Melting Point |
55 oC (Forastieri, H., Ingham, K.C. J. Biol. Chem. 257:7976-7981 (1982)) |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.063 |
| Isoelectric Point |
8.44 |
| Biotransformation |
Not Available |
| Half Life |
4.4 hours (mammalian reticulocytes, in vitro) |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Lutropin_alfa.html |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00056 |
| CAS Registry Number |
152923-57-4 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA10306 |
| SwissProt ID |
LSHB_HUMAN (P01229) |
| GenBank ID |
X00264 |
| Drug ID Number [DIN] |
Not Available
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