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Loxapine
drug data and news
Loxapine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Loxapine | ||
| Brand Names/Synonyms | CHEMBANK4362; Cloxazepine; Dibenzacepin; Dibenzoazepine; HF3170; HSDB 3111; Hydrofluoride 3170; L106; LW 3170; Lossapina [Dcit]; Loxapac; Loxapin; Loxapina [Inn-Spanish]; Loxapine; Loxapine Succinate; Loxapine [Usan:Ban:Inn]; Loxapinum [Inn-Latin]; Loxepine; Loxitane; Loxitane C; Loxitane Im; Oxilapine; S 805; S-805; SUM 3170 | ||
| Indication | For the management of the manifestations of psychotic disorders | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established. | ||
| Mechanism Of Action | Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. | ||
| Loxapine News (When available) |
Medical News Today (press release), ...a) Zyprexa as a first-line treatment (n=229), b) first-line treatment with conventional antipsychotics such as perphenazine, loxapine, haloperidol, thiothixene ... Data also showed Zyprexa was significantly more effective than ... Dec 20, 2005 Biotech Intelligence (press release), ...a) Zyprexa as a first-line treatment (n"9), b) first-line treatment with conventional antipsychotics such as perphenazine, loxapine, haloperidol, thiothixene ... | ||
| Dosage Forms | Tablet; Capsule; Oral Solution; IV Solution; IM Solution | ||
| Drug_Category | Antipsychotics; Antipsychotics; Dopamine Antagonists; ATC:N05AH01 | ||
| Absorption | Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers | ||
| Interactions |
Interactions for Loxapine: There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam. The risk of using loxapine in combination with CNS-active drugs has not been systematically evaluated. Therefore, caution is advised if the concomitant administration of loxapine and CNS-active drugs is required. | ||
| Toxicity | LD50=65 mg/kg (Orally in mice) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | C18H18ClN3O | ||
| Molecular Weight | 327.808 g/mol | ||
| Smiles String | CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl | ||
| Melting Point | 109-110 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 3.162 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | Oral-4 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Loxapine.html http://www.rxlist.com/cgi/generic2/loxapineoc.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00574 | ||
| CAS Registry Number | 10/2/1977 | ||
| KEGG Compound ID | C07104 | ||
| PubChem ID | SID:9315 | ||
| PharmGKB ID | PA450273 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2255448 |
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