Loratadine drug data and news

Loratadine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Loratadine
Brand Names/Synonyms Aerotina; Alarin; Alavert; Alerpriv; Allertidin; Bedix Loratadina; Biloina; Bonalerg; CHEMBANK1389; Civeran; Claratyne; Claratyne Cold; Claratyne Decongestant; Clarinase; Clarinase Reperabs; Clarinex; Claritin; Claritin Reditab; Claritin Reditabs; Claritin-D; Claritine; Clarityn; Clarityne; Fristamin; Histaloran; Lergy; Lertamine; Lesidas; Lisino; Loracert; Loradex; Loradif; Loranox; Lorantis; Lorastine; Loratadina [Spanish]; Loratadine; Loratadine [Usan:Ban:Inn]; Loratadinum [Latin]; Loratyne; Loraver; Lorfast; Loritine; Lowadina; Nularef; Optimin; Polaratyne; Pylor; Restamine; Rhinase; Rinomex; Sanelor; Sensibit; Sinhistan Dy; Sohotin; Tadine; Talorat Dy; Velodan; Versal; Zeos
Indication For the relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and for the treatment of chronic idiopathic urticaria in patients 2 years of age or older
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Description Not Available
Pharmacology Loratadine, a non-sedating H1-blocker similar in structure to cyproheptadine and azatadine, is used to treat seasonal allergic rhinitis. Unlike other H1-blockers, loratidine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.
Mechanism Of Action Like other H1-blockers, loratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Loratadine also has a weak affinity for acetylcholine and alpha-adrenergic receptors.
Loratadine News
(When available)

Cancers seen in SP trial of HIV drug vicriviroc  07 Mar 2006
...in development that will help bring it out of a slump caused by the loss of patent protection on its blockbuster antihistamine Claritin (loratadine) in 2002 ... - Pharma Times (subscription),

8th-grader brings cocaine to school  Mar 4, 2006
Principal Raymond O'Malley also found a plastic baggie containing cocaine, a pink cigarette lighter and two small pills in packaging labeled Loratadine. ... - Brockton Enterprise,

Girl, 9, charged with drugs  Mar 4, 2006
...baggy of cocaine in the girl's handbag, along with a small white straw, a cigarette lighter, and two pills in packaging labeled Loratadine, an antihistamine. ... - Taunton Gazette,

Guest View: State Misses Chance to Save Cash  Feb 16, 2006
With a cost benefit to the patient, the pharmacist could substitute an equally therapeutic alternative like Loratadine. The cost ... - Mountain View Journal,

CAFC Underscores Need to Corroborate Reduction to Practice  Feb 7, 2006
Rolabos 827 patent and Medichems 100 patent both claim a process for making loratadine, the active ingredient in the allergy medication Claritin. ... - Patent Baristas,

OTC Decongestant Nothing To Sneeze At  Feb 21, 2006
...fever. And the nonsedating antihistamine loratadine (Claritin) is considered the first-line, over-the-counter allergy treatment. ... - CBS News

CombinatoRx Discontinues CRx-140 as an Oral Product Candidate For ...  Feb 22, 2006
...neither component alone can achieve. CRx-140 contains a low dose of cyclosporine and loratadine. The target product profile for ... - Genetic Engineering News,

warning on cough medicines  Feb 7, 2006
But newer non-drowsy antihistamines -- such as loratadine, found in Claritin -- are ineffective at reducing cough tied to the common cold, Irwin said. ... - NorthJersey.com,

Non-Inventors Sloppy Lab Notebook Cannot Corroborate Reduction to ...  Feb 8, 2006
The parties here are sparing over rights to a novel process for making loratadine, the active ingredient of Claratin®. Rolabo filed ... - Patently-O,

New Survey Shows Europeans' Allergy Symptoms Are Most Severe in ...  Feb 14, 2006
Products from the company's research efforts include the CLARITIN(R) (loratadine) family of nonsedating antihistamines, NASONEX(R) (mometasone furoate ... - PR Newswire UK (press release),

Need help surfing cold and flu medicines?  Feb 1, 2006
...do not cause drowsiness are available by prescription, but only Tavist ND and Claritin, which both contain the same antihistamine, loratadine, are available ... - South Bend Tribune,

CAFC Underscores Need to Corroborate Reduction to Practice  Feb 7, 2006
Rolabos 827 patent and Medichems 100 patent both claim a process for making loratadine, the active ingredient in the allergy medication Claritin. ... - Patent Baristas,

Non-Inventors Sloppy Lab Notebook Cannot Corroborate Reduction to ...  Feb 8, 2006
The parties here are sparing over rights to a novel process for making loratadine, the active ingredient of Claratin®. Rolabo filed ... - Patently-O,

warning on cough medicines  Feb 7, 2006
But newer non-drowsy antihistamines -- such as loratadine, found in Claritin -- are ineffective at reducing cough tied to the common cold, Irwin said. ... - NorthJersey.com,

Schering-Plough swings to profit in Q4  Jan 31, 2006
On the plus side, turnover of Clarinex in other territories grew 16% to $63 million, and prescriptions of Claritin (loratadine), Clarinex' predecessor, were up ... - Pharma Times (subscription),

Need help surfing cold and flu medicines?  Feb 1, 2006
...do not cause drowsiness are available by prescription, but only Tavist ND and Claritin, which both contain the same antihistamine, loratadine, are available ... - South Bend Tribune,

You may not be able to find your favorite decongestant  Dec 6, 2005
In the drug realm, antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), cetirizine (Zyrtec), and loratadine (Claritin) can ... - DetNews.com,

Generics Take Off  Nov 8, 2005
Schering-Plough beat generics companies to the punch by launching Clarinex, an over-the-counter version of its own Claritin (loratadine), shortly after ... - Drug Discovery & Development (subscription),

Saving Money On Prescription Drugs  Sep 28, 2005
Loratadine for allergies is a good example of an over-the-counter (OTC) medicine that is less expensive than brand-name prescription alternatives, Hunter says. ... - FDA.gov

Many meds don't mix with the sun  Sep 21, 2005
Orinase). Antihistamines: Cetirizine (Zyrtec), cyproheptadine (Periactin), diphenhydramine (Bena-dryl), loratadine (Claritin). Anti ... - Pioneer Press,

Earnings: BATM cuts losses as sales rise  08 Sep 2005
...development. In addition, the company booked charges of $6.6m. for the recalls of loratadine and infant drop products. Excluding ... - Jerusalem Post,

Perrigo merger in pain  Sep 7, 2005
Since November, Perrigo has been hammered by a series of recalls, including loratadine syrup for hayfever and infant pain relievers that were packed with ... - The Grand Rapids Press,

Perrigo Company Reports Fiscal Year 2005 Financial Results  Sep 7, 2005
...acquired 23.4 18.2 * Estimated settlement of class action lawsuits 4.5 2.9 $426.7 $415.6 Net income was also impacted by charges for the loratadine and infant ... - PR Newswire (press release),

Perrigo, Agis Industries suffer post-merger blues  Sep 1, 2005
Just a week after the announcement, it said it was initiating a retail-level recall of all lots of loratadine syrup, a liquid antihistamine used for relieving ... - International Herald Tribune,

Pocketbook Relief for Allergy Sufferers: Consumer Reports Project ...  Aug 11, 2005
...name prescription drug can find just as effective relief at a sixth the cost - or even less - by considering the over-the-counter drug loratadine, the latest ... - WebWire (press release),

Sneezing a lot? Blame allergies  Sep 1, 2005
...your reaction. He suggests loratadine, a generic, over-the-counter nonsedating antihistamine. Claritin is one brand name. Once you ... - Kansas.com,

Patient Power: Over-the-Counter Drugs Brief Analysis  Aug 22, 2005
...an OTC version, a month’s supply of OTC Claritin is available for $22.37, and generic OTC versions with the same active ingredient (loratadine) sell for less ... - National Center for Policy Analysis,

Govt decides to appoint 2 directors on Morepen board as co ...  Jul 6, 2005
...public. Morepen’s woes are linked to its miscalculation of the patent term renewal of an anti-allergy medicine called Loratadine. ... - Economic Times

Schering-Plough Expands Its Presence in Asia Pacific; Commercial ...  Jul 6, 2005
Corporation will continue to market and sell several of the company's primary care products, including the allergy products CLARITIN(R) (loratadine) and NASONEX ... - PharmaLive.com (press release)

FDA Approves Orally Disintegrating Prescription Antihistamine, Re ...  Jul 23, 2005
Products from the company's research efforts include the CLARITIN( R ) ( loratadine ) family and NASONEX( R ) ( mometasone furoate monohydrate ) Nasal Spray ... - I-Newswire.com (press release)

Over the counter: antihistamines  Jul 8, 2005
But generic versions of the same treatments — chlorphenamine, cetirizine and loratadine (all available OTC) — are £1.20 for 28, £2.54 for 30 and £1.98 ... - Times Online <**results**>

Schering-Plough Expands Its Presence in Asia Pacific; Commercial ...  Jul 7, 2005
Corporation will continue to market and sell several of the company's primary care products, including the allergy products CLARITIN® (loratadine) and NASONEX ... - Pharmaceutical Processing

Govt decides to appoint 2 directors on Morepen board as co ...  Jul 6, 2005
...public. Morepen’s woes are linked to its miscalculation of the patent term renewal of an anti-allergy medicine called Loratadine. ... - Economic Times

A Question Of Health  Jun 28, 2005
Both the Boots brand and Clarityn contain 10mg of loratadine. ... These also contain 10mg of loratadine, but only cost 39p for seven tablets. ... - Independent

Over the counter: antihistamines  Jul 8, 2005
But generic versions of the same treatments — chlorphenamine, cetirizine and loratadine (all available OTC) — are £1.20 for 28, £2.54 for 30 and £1.98 ... - Times Online

Fewer Prescriptions, Lower Costs Follow Claritin's OTC Switch, USA  Jun 12, 2005
...became available without a prescription in 2002, insurance plans and consumers spent less on the prescription form of its main ingredient, loratadine, and all ... - Medical News Today

NASONEX(R) (mometasone furoate monohydrate) Effective for Nasal ...  Jun 29, 2005
Products from the company's research efforts include the CLARITIN® (loratadine) family of nonsedating antihistamines, CLARINEX® (desloratadine) syrup and ... - Yahoo News (press release)

Chronic Fatigue Syndrome  Jul 1, 2005
...ibuprofen. Antihistamines such as loratadine, and decongestants that contain pseudoephedrine may relieve allergy-like symptoms. ... - Health24.com

Allergy medications: Know your options  Jun 25, 2005
Newer, second-generation antihistamines — such as loratadine (Claritin), which is available over-the-counter — are less likely to cause sedation. ... - MayoClinic.com

Pollen attacking region's noses  Jun 17, 2005
For people with less severe symptoms, Shah recommends an over-the-counter medication such as Loratadine (Claritin, Alavert) or Benadryl. ... - Foster's Daily Democrat,

Dosage Forms Tablet; Syrup
Drug_Category Anti-allergic Agents; Antipruritics; Antihistamines; Histamine H1 Antagonists, Non-Sedating; ATC:R06AX13; ATC:R06AX27
Absorption Loratadine was rapidly absorbed following oral administration (40% bioavailability)
Interactions -->Interactions for Loratadine:

Loratadine (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of loratadine and/or descarboethoxyloratadine were observed following coadministration of loratadine with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of loratadine, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of loratadine relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.

TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Loratadine and Descarboethoxyloratadine After 10 Days of Coadministration (Loratadine 10 mg) in Normal Volunteers
  Loratadine Descarboethoxyloratadine
 Erythromycin (500 mg q8h) + 40% +46%
 Cimetidine (300 mg qid) +103% + 6%
 Ketoconazole (200 mg q12h) +307% +73%


There does not appear to be an increase in adverse events in subjects who received oral contraceptives and loratadine.

Toxicity somnolence, tachycardia, and headache LD50=mg/kg(orally in rat)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Chemical Formula C22H23ClN2O2
Molecular Weight 382.883 g/mol
Smiles String CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Melting Point 134-136 °C
Water Solubility 0.000011 mg/ml
State white to off-white powder
LogP/Hphobicity 3.646
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 8.4 hours
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Loratadine.html
http://www.rxlist.com/cgi/generic/lorat.htm
Drug Type Approved Drug
Accession No APRD00384
CAS Registry Number 79794-75-5
KEGG Compound ID D00364
PubChem ID SID:192028
PharmGKB ID PA450266
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2244692

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