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Loperamide
drug data and news
Loperamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Loperamide | ||
| Brand Names/Synonyms | Apo-Loperamide; Diarr-Eze; Diarrhea Control; Ii; Imodium; Imodium a-D; Imodium a-D Caplets; Ioperamide; Kaopectate Ii; Loperacap; Loperamida [Inn-Spanish]; Loperamide; Loperamide Hcl; Loperamidum [Inn-Latin]; Maalox Anti-Diarrheal; Nu-Loperamide; Pepto Diarrhea Control; Pms-Loperamide; Rho-Loperamide | ||
| Indication | For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide hydrochloride is also indicated for reducing the volume of discharge from ileostomies. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide is also indicated for reducing the volume of discharge from ileostomies. In man, Loperamide prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex | ||
| Mechanism Of Action | in vitro and animal studies show that Loperamide acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Loperamide inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall. It is a non-selective calcium channel blocker and binds to opioid mu-receptors. Evidence also suggests that at higher concentrations it binds to NMDA receptors and to calmodulin | ||
| Loperamide News (When available) |
Diarrhea: Cancer-related causes and how to cope Mar 2, 2006 WV's 480 botika ng barangay sell cheaper medicines Feb 21, 2006 From the analyst's couch: The IBS market Feb 15, 2006 E. Coli Defense Mechanism May Provide Key to Disrupting Bacteria ... Jan 16, 2006 A 2-Week-On, 2-Week-Off Schedule Appears Optimal for BIBW 2992 in ... Nov 21, 2005 HUGIN NEWS/Actelion and UCB enter into assignment and license ... Nov 16, 2005 Why do they call this stuff chili if it’s so darn hot? Nov 9, 2005 Azithromycin/Loperamide Comparable to Levofloxacin/Loperamide for ... Oct 11, 2005 Desk diners in UK hits 12 million Oct 11, 2005 Botika sa Barangay sells cheap medicines to mountain barangays Oct 1, 2005 Azithromycin/Loperamide Comparable to Levofloxacin/Loperamide for ... 11 Oct 2005 Desk diners in UK hits 12 million 11 Oct 2005 Botika sa Barangay sells cheap medicines to mountain barangays Oct 1, 2005 HEALTH WARNINGS FOR TRAVELERS' Sep 13, 2005 McNeil Consumer & Specialty Pharmaceuticals Statement Regarding ... Sep 13, 2005 McNeil Consumer & Specialty Pharmaceuticals Statement Regarding ... Sep 13, 2005 Parents May Not Be Aware of FDA Guidelines for Treating Children ... Sep 9, 2005 Parents May Not Be Aware of FDA Guidelines for Treating Children ... 08 Sep 2005 Clinical Trials Currently Recruiting Patients With Irritable Bowel ... Aug 22, 2005 STRONG MEDICINE NEEDED FOR OUT-OF-CONTROL IRRITABLE BOWEL SYNDROME Aug 9, 2005 Data Shows That ADHD Patients on CONCERTA (Methylphenidate HCl) ... Jun 28, 2005 Data Shows That ADHD Patients on CONCERTA(R) (Methylphenidate HCl) ... Jun 28, 2005 Escherichia coli O157:H7 Frequently Asked Questions Jun 13, 2005 Escherichia coli O157:H7 Frequently Asked Questions Jun 13, 2005 Acetaminophen Provides Pain Relief Equal to Ibuprofen in Treatment ... Jun 4, 2005 New Study Shows Acetaminophen Provides Pain Relief Equal to ... Jun 3, 2005 Munna Bhai MBBS and his magic cures Apr 3, 2005 Some Basics about E. coli Infection Apr 2, 2005 Escherichia coli O157:H7 Frequently Asked Questions Mar 1, 2005 Postdural Puncture Headache with Abdominal Pain and Diarrhea Feb 22, 2005 Dealing with the Dreaded D-word? Feb 22, 2005 | ||
| Dosage Forms | TABLET; CAPSULE; LIQUID | ||
| Drug_Category | Antidiarrheals; Antidiarrheals; ATC:A07DA03; ATC:A07DA05 | ||
| Absorption | Not well absorbed from gastrointestinal tract | ||
| Interactions |
Interactions for Loperamide: There was no evidence in clinical trials of drug interactions with concurrent medications. | ||
| Toxicity | Overdoses can cause bloating, nausea, vomiting, constipation, dehydration. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide | ||
| Chemical Formula | C29H33ClN2O2 | ||
| Molecular Weight | 477.037 g/mol | ||
| Smiles String | CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4 | ||
| Melting Point | 223 °C | ||
| Water Solubility | Mostly insoluble | ||
| State | Solid | ||
| LogP/Hphobicity | 6.249 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Primarily hepatics | ||
| Half Life | 10.8 hours (9.1-14.4 hours) | ||
| Protein Binding [%] | 97% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Loperamide.html http://www.rxlist.com/cgi/generic3/loperamide.htm http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/imo1206.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00275 | ||
| CAS Registry Number | 53179-11-6 | ||
| KEGG Compound ID | C07080 | ||
| PubChem ID | SID:9291 | ||
| PharmGKB ID | PA450262 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2240415 |
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