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Levofloxacin
drug data and news
Levofloxacin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Levofloxacin | ||
| Brand Names/Synonyms | Cravit; Cravit Ophthalmic; Elequine; Floxel; IQUIX; Leroxacin; Lesacin; Levaquin Leva-Pak; Levaquin; Levokacin; Levox; Levoxacin; Mosardal; Nofaxin; Quixin; Reskuin; Tavanic; Volequin | ||
| Indication | For the treatment of Bacterial infection of; Respiratory tract, Urinary tract, GI, CNS and Immuno compromised patients caused by: S.pneumoniae, H.influenzae, M.catarrhalis, S.aureus, H.parainfluenzae, P.aeruginosa, S.marcescens, E.coli, K.pneumoniae, C.pn | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. | ||
| Mechanism Of Action | Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited. | ||
| Levofloxacin News (When available) |
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| Dosage Forms | TABLET, LIQUID, SOLUTION | ||
| Drug_Category | Anti-bacterial Agents; Anti-Infectives; Quinolones; ATC:J01MA12; ATC:S01AX19 | ||
| Absorption | Absorption of ofloxacin after single or multiple doses of 200to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose. | ||
| Interactions | Interactions for Levofloxacin: Specific drug interaction studies have not been conducted with Levofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving systemic cyclosporine concomitantly. | ||
| Toxicity | Side effects include disorientation, dizziness, drowsiness, hot and cold flashes, nausea, slurring of speech, swelling and numbness in the face | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate | ||
| Chemical Formula | C36H42F2N6O9 | ||
| Molecular Weight | 740.751 g/mol | ||
| Smiles String | CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O.CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O.O | ||
| Melting Point | Not Available | ||
| Water Solubility | Insoluble | ||
| State | Solid | ||
| LogP/Hphobicity | 1.268 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 6-8 hours . | ||
| Protein Binding [%] | 24-38% (to plasma proteins) | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/flo1181.shtml http://www.drugs.com/cons/Levofloxacin.html http://www.rxlist.com/cgi/generic2/quixin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00477 | ||
| CAS Registry Number | 100986-85-4 | ||
| KEGG Compound ID | C07660 | ||
| PubChem ID | SID:9862 | ||
| PharmGKB ID | PA450214 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2248263 |
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