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Levallorphan
drug data and news
Levallorphan drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Levallorphan
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| Brand Names/Synonyms |
HSDB 2148; LEVALLORPHAN; Levallofano [Dcit]; Levallorphan; Levallorphane [Inn-French]; Levallorphanum [Inn-Latin]; Levalorfano [Inn-Spanish]; Lorfan; Naloxiphan |
| Indication |
For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids. |
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Description |
Not Available |
| Pharmacology |
Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphan differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphan prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. |
| Mechanism Of Action |
Levallorphan antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3. |
Levallorphan News
(When available) |
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| Dosage Forms |
Solution for injection (intramuscular, subcutaneous or intravenous) |
| Drug_Category |
Analgesic Antagonists; Morphine Antidotes; Antinarcotic Agents; Narcotic Antagonists |
| Absorption |
Rapidly absorbed. |
| Interactions |
Not Available |
| Toxicity |
Oral, rat LD50: 109±4 mg/kg |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
adamantan-1-amine |
| Chemical Formula |
C19H25NO |
| Molecular Weight |
283.408 g/mol |
| Smiles String |
C=CCN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O |
| Melting Point |
181 °C |
| Water Solubility |
633 mg/L |
| State |
Solid |
| LogP/Hphobicity |
4.546 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Hepatic. |
| Half Life |
1 hour |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00733 |
| CAS Registry Number |
152-02-3 |
| KEGG Compound ID |
C07069 |
| PubChem ID |
SID:152219 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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