Ketamine drug data and news

Ketamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Ketamine
Brand Names/Synonyms CI 581 base; CLSTA 20; Esketamine; Ketaject; Ketalar; Ketalar base; Ketamine; Ketamine Base; Ketamine HCL; Ketanest; Ketolar; l-Ketamine; (-)-Ketamine; (S)-(-)-Ketamine; (S)-Ketamine
Indication For use as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation
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Description Not Available
Pharmacology Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketamine has been termed “dissociative anesthesia” in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems).
Mechanism Of Action Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, Ketamine does not interact with GABA receptors.
Ketamine News
(When available)

What Ecstasy does to you  07 Mar 2006
But many Ecstasy tablets contain other substances, including ketamine, amphetamine, caffeine and other man-made or toxic substances. ... - ic Wales,

Gay teens more likely to use 'club drugs'  07 Mar 2006
The study, published in the current BC Medical Journal, shows 13.6 per cent of teenagers reported using either crystal meth, ecstasy, ketamine or GHB, the date ... - Vancouver Sun (subscription),

Man arrested in record ketamine haul  Feb 22, 2006
Police have seized a record 200kg of ketamine worth $60 million and arrested a 47-year-old man in Cheung Sha Wan. Officers ambushed ... - News.gov.hk,

NBI raid nets biggest ketamine drug haul  Feb 16, 2006
AGENTS of the National Bureau of Investigation (NBI) seized during a raid on Wednesday P53 million worth of ketamine hydrochloride, described as "the biggest ... - INQ7.net,

NBI raid on Parañaque house yields P53M worth of ketamine  Feb 15, 2006
NATIONAL Bureau of Investigation agents seized on Wednesday 53 million pesos worth of ketamine hydrochloride, an illegal drug, during a raid on a house in ... - INQ7.net,

NBI SEIZES P53-M KETAMINE  Feb 17, 2006
...in large-scale importation and distribution of dangerous drugs during a raid that resulted in the seizure of R53 million worth of Ketamine Hydrochloride (known ... - Tempo,

Ketamine Attenuates Sympathetic Activity Through Mechanisms not ...  Feb 22, 2006
Address e-mail to cmho{at}vghtpe.gov.tw. Ketamine is believed to have sympathomimetic effects, although the central mechanism remains unclear. ... - Anesthesia & Analgesia (subscription),

CNB busts drug group, nabs 16 suspects  Mar 3, 2006
During the two-day operation from March 1-2, officers also seized synthetic drugs comprising about 30 grammes of ketamine, 5 grammes of 'Ice' and five Erimin-5 ... - Channel News Asia,

Drug Use Higher in Gay Teens  Mar 5, 2006
The study surveyed 607 students from six Canadian high schools. 14% of participants admitted to having used either crystal meth, ecstasy, ketamine or GHB. ... - Gay NZ,

London is world's cocaine capital  Mar 4, 2006
The Mixmag survey, regarded as a reliable indicator of drug trends by police and lawyers, also found that ketamine and Viagra were increasing in popularity. ... - Independent,

I nearly stepped on needles  Mar 3, 2006
But there is no punishment for abusers. It is like what ketamine abuse used to be before 1999, when the drug was classified under the Poisons Act. - Electric New Paper,

Keeping Union County students safe during Spring Break  Mar 3, 2006
Never accept an open drink from someone you do not know. Date rape drugs, such as GHB, Ketamine and Rohypnol are undetectable. Never ... - Union Sentinel,

BUSINESS OWNER FACES DRUG CHARGE  Mar 3, 2006
He also entered no plea on charges of possession of marijuana with intent to deliver; possession of Ketamine; and possession of a .40-calibur, semi-automatic ... - Westerly Sun,

Couple arrested for drug production, selling in E. China province  Feb 23, 2006
Local police captured 6.86 kilograms of Ketamine, a kind of drug, and 1.47 million yuan (180,000 US dollars) in cash, in addition to equipment and materials ... - People's Daily Online,

Man arrested on drugs and weapons charges  Mar 1, 2006
The list of charges grew after the police searched his apartment and found ecstasy, an anesthetic known as ketamine, a 40-caliber handgun and about a pound of ... - Providence Journal (subscription),

Dysbindin Genotype and Negative Symptoms in Schizophrenia  Mar 2, 2006
Since glutamatergic antagonists such as ketamine can produce negative symptoms in healthy individuals and exacerbate negative symptoms in schizophrenia (8 ... - Am J Psychiatry (subscription)

Drug abuse cases hit yet another record low in 2005  Feb 13, 2006
Erimin-5 abusers made up 26% of those arrested, and Ketamine 24%. ... In September, narcotics officers made their largest-ever Ketamine bust. ... - Channel News Asia,

A short history of cocaine  Mar 4, 2006
Taken with low doses of ketamine, in a combination clubbers know as CK1, it diminishes the hallucinogenic and paralysing effects of K; taken with high doses ... - The Statesman,

Seized drugs part of big shipment?  Feb 17, 2006
THE P53 million worth of ketamine seized by the National Bureau of Investigation and the Philippine Drug Enforcement Agency in Parañaque City last Wednesday ... - Journal Online,

HK among world safest cities  Feb 25, 2006
Customs and Excise Department as well as the Police have enhanced their efforts in law enforcement resulting in a record seizure of certain drugs like Ketamine ... - EastDay.com,

Cops confiscate P53m in drugs  Feb 16, 2006
By Michael Caber. AUTHORITIES raided a drug lair of an Indian national and seized P53 million worth of Ketamine in Parañaque City last Wednesday. ... - Manila Standard Today,

Number of cases twice that of 2005  Feb 15, 2006
Mainland border police have seized 117 kilograms of heroin, Ketamine and drug-related chemicals, with 23 suspects under arrest in 22 cases. ... - People's Daily Online,

Users of shabu shift to tranquilizers: PNP  Feb 9, 2006
Police investigations have shown that most of the students in Bacolod who are users, prefer tranquilizers such as Ketamine and Valium since they are cheaper ... - Visayan Daily Star,

Deadly rampage of loner 'who dreamt of being a serial killer'  Feb 28, 2006
...by his desire to seek excitement from excessive consumption of alcohol and misuse of a variety of drugs, including cocaine, Ecstasy, amphetamine and ketamine. ... - Times Online,

Wanted gunman Tan Chor Jin handed over to Singapore Police  Mar 1, 2006
25. They seized six semi-automatic pistols, 203 rounds of ammunition and four kilogrammes of ketamine drugs worth RM50,000. Another ... - Channel News Asia,

Eyes of an executioner?  Feb 27, 2006
The 4kg of ketamine found in the rooms have a street value of RM50,000 ($21,800), reported Malaysia's New Straits Times yesterday. ... - Electric New Paper,

He whistles... smiles... and demands food while in M'sian prison  Mar 2, 2006
Besides two pairs of handcuffs and 4 kg of ketamine, the police also found six semi-automatic pistols, 203 bullets and two silencers in one of the rooms. ... - Electric New Paper,

Jobless man dreamed of being a famous serial killer  Feb 28, 2006
He later told the police that during weekends he took "speed, ecstasy, cocaine, ketamine - as he described it ’anything like that'". ... - Times Online,

Murder suspect handed over to Singapore police  Mar 1, 2006
The suspects were among six people arrested at a hotel in Jalan Imbi here with six pistols, 203 rounds of ammunition and 4kg of ketamine on Saturday. - Malaysia Star,

Knifeman who killed 4 wanted to be serial killer  Feb 28, 2006
...early hours of Monday. Gonzalez had also admitted to police that he took speed, ecstasy, cocaine, ketamine and "anything like that.". - Life Style Extra,

Two S'poreans wanted for murder held at hotel  Feb 27, 2006
...rooms on the 13th floor of the hotel, police also seized six pistols of various types, 203 rounds of ammunition and four kilogrammes of ketamine drugs valued ... - Daily Express,

Scientists say smoking cannabis DOESN'T lead to taking harder ...  Mar 1, 2006
...for possession. Class C drugs include cannabis, steroids, and the tranquillizer ketamine which carry two years for possession. The ... - Mirror.co.uk,

‘One-Eyed Dragon’ handed over to Singapore police  Mar 1, 2006
...handcuffs and 203 bullets. Also seized were four kilos of Ketamine with a street value of RM50,000. Police yesterday obtained a ... - Malay Mail,

The Tongue Flap: An Iatrogenic Difficult Airway?  Feb 21, 2006
...was divided. The patient was sedated with IV ketamine 50 mg. Glycopyrrolate 0.2 mg was administered to control secretions. The surgeons ... - Anesthesia & Analgesia (subscription),

Student is quizzed over danger drug  Mar 1, 2006
..."We've had cases of people going into comas when they've combined this drug with alcohol or Ketamine. "Originally it was used by body builders. ... - Cambridge Evening News,

Undergrads nabbed in raid on WILD PARTY  Feb 28, 2006
Some of the students had apparently tried to dispose of the drugs. Other than Ecstasy, Syabu (Ice) and Ketamine were also found. ... - Electric New Paper,

Drug trafficker jailed 28 months  Mar 2, 2006
Officers intercepted him after he left his residence on Yuk Nga Lane, Tseung Kwan O, at 7pm, August 9. They found 332g of ketamine worth $65,000, an electronic ... - News.gov.hk,

Over RM1m drugs seized  Feb 14, 2006
PENANG: More than RM1mil of illicit narcotics including heroin and ketamine have been seized from 14 people including four women at various parts in the state ... - Malaysia Star,

Chinese customs seize 117 kg of drugs since start of 2006  Feb 15, 2006
..."More ketamine is being smuggled into China," he said. Figures show that since the beginning of this year, four such cases have ... - People's Daily Online,

Two Singaporeans wanted for murder arrested in Malaysia  Feb 25, 2006
In the raid conducted in a 5-star hotel in downtown Kuala Lumpur, police seized 6 pistols, 203 rounds of ammunition and at least 4 kilograms of ketamine drugs. ... - Xinhua,

Wacky Animal-Rights Tricks, Investor's Edition  Feb 22, 2006
...animals the same way you do? Our guess is that it's because chicken injected with ketamine and pentobarbital doesn't taste very good. - Consumer Freedom,

‘One-eyed dragon’ caught napping  Feb 26, 2006
...handcuffed and led away. In the room, police found six semi-automatic pistols and 203 bullets, along with 4kg of ketamine. A source told ... - Malay Mail,

Murder suspect was on the move in KL  Feb 26, 2006
Asleep at the time, the men gave up without a struggle. Six semi-automatic pistols, 203 bullets and 4kg of ketamine were found in their rooms. ... - TODAYonline,

Singapore drug arrests down 17 percent last year compared to 2004 ...  Feb 14, 2006
Abusers of synthetic drugs such as ketamine, ecstasy, and nimetazepam _ a depressant also known as Erimin 5, made up 79 percent of arrests in 2005, the bureau ... - China Post,

February 26, 2006 Arrests and legal briefs  Feb 26, 2006
5 with having cocaine, hallucinogenic mushrooms, LSD, Ecstasy, ketamine, marijuana and drug scales during the moe.down concert at the Snow Ridge Ski Area in ... - Jon Sabin Private Investigator,

January crime rate down 0.5%  Feb 25, 2006
The Customs & Excise Department and Police have increased efforts in drug enforcement resulting in a record seizure of ketamine, and a fall in the number of ... - News.gov.hk,

Wild party busted, 74 held  Feb 26, 2006
...in. “We also found ecstasy, syabu and ketamine on the floor and in the toilet. All 44 men and 30 women were tested for drugs.�. ... - Malay Mail,

Singaporeans arrested in raid  Feb 25, 2006
...“Also seized were four kilos of ketamine, estimated to be worth around RM50,000 on the market,� he told a Press conference at the City police headquarters ... - Malay Mail,

Dosage Forms SOLUTION
Drug_Category Anesthetics; Analgesics; General Anesthetics; ATC:N01AX03; ATC:N01AX14
Absorption Rapidly absorbed following parenteral administration
Interactions Interactions for Ketamine: Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with ketamine. Ketamine is clinically compatible with the commonly used general and local anesthetic agents when an adequate respiratory exchange is maintained.
Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-(2-chlorophenyl)-2-methylamino-cyclohexan-1-one
Chemical Formula C13H16ClNO
Molecular Weight 237.725 g/mol
Smiles String CNC1(CCCCC1=O)C2=CC=CC=C2Cl
Melting Point 92.5 °C
Water Solubility Not Available
State Solid
LogP/Hphobicity 3.032
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life ~2.5 3 hours.
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Ketamine.html
http://www.rxlist.com/cgi/generic3/ketamine.htm
Drug Type Approved Drug
Accession No APRD00493
CAS Registry Number 6740-88-1
KEGG Compound ID C07525
PubChem ID SID:9728
PharmGKB ID PA450144
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2246796

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