Isotretinoin drug data and news

---

Huddersfield Town 2, Doncaster Rovers 2  07 Mar 2006
...against Doncaster. Neither manager could understand why referee Andy D'Urso disallowed Andy Booth's header on 70 minutes. But Town ... - ic Huddersfield.co.uk,

Right people in right jobs key to Radiophone's success  07 Mar 2006
...company and increase revenues. How business started: Urso George was a pioneer in the communication industry. He worked for Galvin ... - News-Leader.com,

Josephine Marie Fieata  07 Mar 2006
...residence in Geneva. She was born July 4, 1907, in Painesville, the daughter of Lucaiano Urso and Antonia (Pustiro) Urso. She helped ... - News-Herald.com,

ITALY-USA: URSO, ALLIANCE WITHOUT INFERIORITY COMPLEX  Mar 1, 2006
Adolfo Urso, in the USA together with Premier Silvio Berlusconi, prefers "to concentrate the attention on serious questions". Urso ... - Agenzia Giornalistica Italia,

ITALIAN PRODUCTS: URSO IN ALBANIA WITH 80 ITALIAN FIRMS  Feb 21, 2006
21 - The plan designed by deputy industry minister, Adolfo Urso, envisages an ad hoc fund of 30 million euro for the creation of joint ventures based on 4 ... - Agenzia Giornalistica Italia,

FOREIGN TRADE: URSO - 2006 STARTS WELL FOR MADE IN ITALY  Feb 23, 2006
This means we can say that 2006 will certainly be the year of recovery for Made in Italy"- this was the claim made by Adolfo Urso, deputy minister for trade ... - Agenzia Giornalistica Italia,

MEDITERRANEAN FORUM: URSO, SPECIAL LAW FOR NEXT FIVE YEARS  Feb 20, 2006
...the target that we need to reach by 2010", is the proposal advanced by Deputy Industry Minister, with Responsibility for Foreign Trade, Adolfo Urso, during the ... - Agenzia Giornalistica Italia,

CHINA:URSO, EU DECISIONS OVER SHOES NECESSARY BUT INSUFFICIENT  Feb 23, 2006
This will be the key theme of the meeting with Peter Mandelson on 8 March in Brussels." Thus, Adolfo Urso, Deputy Industry Minister with responsibility for ... - Agenzia Giornalistica Italia,

URSO: 30 MLN EURO FUND FOR NEW JOINT-VENTURES WITH ALBANIA  Feb 22, 2006
These are the main objectives of the draft programme prepared by the deputy minister for productive activities in charge of foreign trade, Adolfo Urso. ... - Agenzia Giornalistica Italia,

TRADE: URSO, ANTIDUMPING DUTIES ON KOREAN FRIDGES SOON  Feb 17, 2006
...high quality side by side refrigerators, from South Korea invading Europe at cut prices." Thus announced Minister for Foreign Trade, Adolfo, Urso, according to ... - Agenzia Giornalistica Italia,

BIRD FLU: URSO, ITALIAN POULTRY IS SAFE, NO TO ALARMISM  Feb 13, 2006
...(AGI) - Rome, Feb. 13 - Deputy Industry minister, Adolfo Urso, speaking about bird flu said that the utmost caution was necessary but it needed no alarmism. ... - Agenzia Giornalistica Italia,

MADE IN ITALY: URSO, BIOTECHNOLOGY IN INTERNATIONAL MARKETS  Feb 8, 2006
This is the objective of the accord marked by Deputy Minister of Productive Activity delegated to Foreign Commercial affairs, Adolfo Urso, with the National ... - Agenzia Giornalistica Italia,

TEXTILES: ITALY-CHINA AGREEMENT HERALDED BY URSO  Feb 2, 2006
China are to sign agreements to study strategies mutually beneficial developments in the textiles and clothing industry, as oer Minister Urso's announcement in ... - Agenzia Giornalistica Italia,

Europeans Again Lift Rates and Hint at More Increases  Mar 3, 2006
...the Continent. Italy's deputy trade minister, Adolfo Urso, said the rate increase was a mistake that would hurt exports. Italy's ... - The Ledger,

For now, Fauquier sticking with the stickers  Feb 28, 2006
...year. And what those changes might be are still in the discussion and study phases, said Commissioner of Revenue Ross D'Urso. "Over ... - Fauquier Times-Democrat,

Watershed group to study helping fish over two dams  Mar 1, 2006
..."It'll pay for an engineering analysis to look at the ability to move fish over those two areas," said Lori Urso, the association's executive director. ... - Providence Journal (subscription),

2nd killer of teen gets life in prison  Feb 24, 2006
..."The only just sentence is that you never see sunlight or touch the ground except from behind bars," said Cook County Judge Joseph Urso in sentencing Reeves, 25 ... - Chicago Tribune,

EU Says France May Break Law in Suez-GDF Merger Case (Update2)  Mar 3, 2006
Adolfo Urso, Italy's deputy industry minister, said France ``has said no to the market and has gone back on some sacred principles.''. ... - Bloomberg

CHARIHO'S CHOICES  Mar 5, 2006
As a result, seven to 10 town jobs may be at stake - a decision that lays in the hands of Interim Town Manager Linda Urso and members of the Town Council ... - Westerly Sun,

Man gets life in girl's murder  Feb 24, 2006
Moments later, Cook County Judge Joseph Urso sentenced Reeves to natural life in prison for the Carol Stream girl's killing -- and rebuked Reeves for ... - Chicago Sun-Times,

Slain teen's mother tells of her anguish  Feb 23, 2006
..."The pain and anguish we went through, no parents should suffer," she told Cook County Judge Joseph Urso on Wednesday. "My family is destroyed. ... - Chicago Tribune,

Argentina extradites Bosnian Serb  Feb 20, 2006
...said. The office of Federal Judge Jorge Urso said Lukic was put on a flight to Spain and was headed ultimately for The Hague. Lukic ... - CNN International

Man gets life sentence for teen's rape, murder  Feb 24, 2006
Cook County Judge Joseph Urso said he would have chosen the death penalty for Turner Reeves III, 25, but he was unsure whether it was Reeves or his accomplice ... - San Jose Mercury News,

ECB Ups Key Interest Rate to 2.5 Percent  Mar 2, 2006
But Italian Deputy Industry Minister Adolfo Urso called the rate decision a mistake. "Following a first increase in rates in December ... - CBS News

Peabody people  Mar 1, 2006
John's Preparatory School students David Ballard, Dennis D'Urso, Stephen Gaudet, Gary Gaudet, Jared Kaminski, Bryan LaRochelle, Daniel Lee, Jesse Marks, Kevin ... - Salem News,

Prosecutors: Prison didn't slow Megale's mob career  Feb 28, 2006
Attorney Lindy Urso said the guidelines that calculated that range already considered Megale's criminal history and adding more time would be unfair. ... - Stamford Advocate,

Axcan announces record revenue of $70.6 million for the first ...  Feb 9, 2006
The names CANASA, CARAFATE, DELURSAN, HELIZIDE, ITAX, LACTEOL, PANZYTRAT, SALOFALK, SULCRATE, ULTRASE and URSO appearing in this press release are trademarks ... - Canada NewsWire (press release),

Argentina sends Bosnian Serb war criminal to Hague  Feb 20, 2006
An official in the office of federal Judge Jorge Urso, speaking on condition of anonymity, said Lukic was handed over to authorities and headed to The Hague. ... - Reuters.uk,

VERONA: LUXURY EXHIBITION BEGINS ON SATURDAY  Feb 21, 2006
Lamborghini, Ducati. The inauguration will be attended by Deputy PM Gianfranco Fini, and deputy Industry Minister Adolfo Urso. (AGI) . - Agenzia Giornalistica Italia,

COUNCILOR ECHOS WOMEN'S CONCERN  Feb 24, 2006
..."I think some procedure needs to be put in place... where someone waiting for police should be notified," Matson told Interim Town Manager Linda Urso. ... - Westerly Sun,

Still rolling  Feb 14, 2006
Tournament co-director John D'Urso said how the tournament started was a simple idea. “It is for bowlers over 50,� D'Urso said. ... - Auburn Citizen,

HOPKINTON DRAWS 23 APPLICATIONS FOR MANAGER'S POST  Feb 3, 2006
Kenney said Wednesday she has received 23 applications for the manager position, which is currently being held on an interim basis by Linda Urso, a former ... - Westerly Sun,

Todd Spehler Drives Soccer Team to Town's First Tournament Success  Feb 10, 2006
The Town of North Hempstead Soccer Advisory Committee, which was created less than a year ago with the help of Councilman Anthony D'Urso, worked tirelessly to ... - PR Web (press release),

BERLUSCONI SPEAKING BEFORE US CONGRESS  Mar 1, 2006
...from a political point of view as well as from an ethical point of view", stated Enrico La Loggia (FI), whereas his colleague Adolfo Urso (Alleanza Nazionale ... - Agenzia Giornalistica Italia,

How young is too young for the catwalk?  Feb 4, 2006
Responding to concerns about children who dream of being the next Natalia Vodianova or Gisele Bundchen, Industry Minister Adolfo Urso wants a code of ethics ... - Guardian Unlimited,

ECB Ups Key Interest Rate to 2.5 Percent  Mar 2, 2006
...a first increase in rates in December, the ECB is wrong to endorse the rates‘ spiral because there is no real danger of inflation in Europe," Urso said in a ... - Herald News Daily,

Seminoles Exact A Bit Of Revenge On Gators With 6-4 Win  Feb 28, 2006
...a four-run deficit to win 7-6. "It was a great day all around," Spartans coach Joe Urso said. "We were definitely here to have a ... - Tampa Tribune,

CENTRAL CATHOLIC OPENS PENGUINS CUP SERIES WITH 9-3 VICTORY  Mar 2, 2006
Christopher Urso led the Vikings with (14-7-2) with three goals and an assist, while Josh Martin assisted on six of Central Catholic’s goals. ... - Pittsburgh Penguins,

Highland girls still nest as DAC's best  Feb 28, 2006
Kidwell to knee problems this season, it's a deep team led by returnees Dani Siccardi, Allison Conners, Miller, Courtney Brewer, Lauren D'Urso and newcomers ... - Fauquier Times-Democrat,

St. John's fencers earn share of state title  Feb 27, 2006
Senior Will Baker also lost a tough 5-4 decision, but was the individual sabre champ for the Eagles. Junior Michael D'Urso surprised for St. ... - Salem News,

Food events  Mar 1, 2006
Networking will begin at 6 pm, with dinner at 6:30. The public is welcome. The cost is $35, $25 for members; call Kelly Urso at (203) 364-1667. ... - Danbury News Times,

ELECTIONS: AN, SURVEYS? WIND HAS CHANGED  Feb 4, 2006
...characteristics. The important thing is to overcome the Unione." Deputy Minister for Industry Adolfo Urso holds a slight different opinion. ... - Agenzia Giornalistica Italia,

Italy suspends seal skin imports  Feb 13, 2006
Adolfo d'Urso, the Italian vice-minister for Trade and Industrial Affairs, announced the moratorium today at a press conference in Rome with the Anti ... - Spero News

Gwinnett swim teams win 10 events over weekend  Feb 14, 2006
Girls 200 medley relay: 3. North (Sarah Looney, Megan D'Urso, Corinna Kovach, Lauren Barnes); 7. Mill Creek (Stephanie Doran, Jordan Evans, Alex Warner, Marlie ... - Atlanta Journal Constitution (subscription),

Jilted Italy considers revenge over French snub  Feb 26, 2006
Once again Paris has raised the barricades which clash with the policy of European integration,� said Deputy Industry Minister Adolfo Urso. - Khaleej Times,

Brussels puts the boot into China over unfair shoe support  Feb 23, 2006
..."Europe must do more and can do more to defend its companies and its workers," Adolfo Urso, Italy's deputy Industry minister said. ... - Independent,

Murderer's family pleads for his life  Feb 23, 2006
...in prison. Prosecutors are seeking a death sentence for Reeves. Judge Joseph Urso could impose a sentence today. Nassim's parents ... - Chicago Sun-Times,

TRADE: AGREEMENT BETWEEN IATT FOR "GREEN" TECHNOLOGIES  Feb 1, 2006
...(AGI) - Rome, February 1 - Trade and Industry Deputy Minister Adolfo Urso and IATT ,Italian Association for Trenchless Technology, have signed a two year ... - Agenzia Giornalistica Italia,

EU puts foot down on imports  Feb 23, 2006
...enough. “Europe must and can do more to defend its companies and workers,� said Italian Deputy Industry Minister Adolfo Urso. ... - Business Day,

· Vitamin A: Because of the relationship of Accutane to vitamin A, patients should be advised against taking vitamin supplements containing vitamin A to avoid additive toxic effects.

· Tetracyclines: Concomitant treatment with Accutane and tetracyclines should be avoided because Accutane use has been associated with a number of cases of pseudotumor cerebri (benign intracranial hypertension), some of which involved concomitant use of tetracyclines.

· Micro-dosed Progesterone Preparations: Micro-dosed progesterone preparations ("minipills" that do not contain an estrogen) may be an inadequate method of contraception during Accutane therapy. Although other hormonal contraceptives are highly effective, there have been reports of pregnancy from women who have used combined oral contraceptives, as well as topical/injectable/implantable/insertable hormonal birth control products. These reports are more frequent for women who use only a single method of contraception. It is not known if hormonal contraceptives differ in their effectiveness when used with Accutane. Therefore, it is critically important for women of childbearing potential to select and commit to use 2 forms of effective contraception simultaneously, at least 1 of which must be a primary form, unless absolute abstinence is the chosen method, or the patient has undergone a hysterectomy.

· Phenytoin: Accutane has not been shown to alter the pharmacokinetics of phenytoin in a study in seven healthy volunteers. These results are consistent with the in vitro finding that neither isotretinoin nor its metabolites induce or inhibit the activity of the CYP 2C9 human hepatic P450 enzyme. Phenytoin is known to cause osteomalacia. No formal clinical studies have been conducted to assess if there is an interactive effect on bone loss between phenytoin and Accutane. Therefore, caution should be exercised when using these drugs together.

· Systemic Corticosteroids: Systemic corticosteroids are known to cause osteoporosis. No formal clinical studies have been conducted to assess if there is an interactive effect on bone loss between systemic corticosteroids and Accutane. Therefore, caution should be exercised when using these drugs together.

Prescribers are advised to consult the package insert of medication administered concomitantly with hormonal contraceptives, since some medications may decrease the effectiveness of these birth control products. Accutane use is associated with depression in some patients. Patients should be prospectively cautioned not to self-medicate with the herbal supplement St. Johnís Wort because a possible interaction has been suggested with hormonal contraceptives based on reports of breakthrough bleeding on oral contraceptives shortly after starting St. John's Wort. Pregnancies have been reported by users of combined hormonal contraceptives who also used some form of St. John's Wort.

Laboratory Tests

Pregnancy Test

Female patients of childbearing potential must have negative results from 2 urine or serum pregnancy tests with a sensitivity of at least 25 mIU/mL before receiving the initial Accutane prescription. The first test is obtained by the prescriber when the decision is made to pursue qualification of the patient for Accutane (a screening test). The second pregnancy test (a confirmation test) should be done during the first 5 days of the menstrual period immediately preceding the beginning of Accutane therapy. For patients with amenorrhea, the second test should be done at least 11 days after the last act of unprotected sexual intercourse (without using 2 effective forms of contraception).

Each month of therapy, the patient must have a negative result from a urine or serum pregnancy test. A pregnancy test must be repeated each month prior to the female patient receiving each prescription.

· Lipids: Pretreatment and follow-up blood lipids should be obtained under fasting conditions. After consumption of alcohol, at least 36 hours should elapse before these determinations are made. It is recommended that these tests be performed at weekly or biweekly intervals until the lipid response to Accutane is established. The incidence of hypertriglyceridemia is 1 patient in 4 on Accutane therapy.

· Liver Function Tests: Since elevations of liver enzymes have been observed during clinical trials, and hepatitis has been reported, pretreatment and follow-up liver function tests should be performed at weekly or biweekly intervals until the response to Accutane has been established.

· Glucose: Some patients receiving Accutane have experienced problems in the control of their blood sugar. In addition, new cases of diabetes have been diagnosed during Accutane therapy, although no causal relationship has been established.

· CPK: Some patients undergoing vigorous physical activity while on Accutane therapy have experienced elevated CPK levels; however, the clinical significance is unknown. There have been rare postmarketing reports of rhabdomyolysis, some associated with strenuous physical activity. In a clinical trial of 217 pediatric patients (12 to 17 years) with severe recalcitrant nodular acne, transient elevations in CPK were observed in 12% of patients, including those undergoing strenuous physical activity in association with reported musculoskeletal adverse events such as back pain, arthralgia, limb injury, or muscle sprain. In these patients, approximately half of the CPK elevations returned to normal within 2 weeks and half returned to normal within 4 weeks. No cases of rhabdomyolysis were reported in this trial.