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Isosorbide Mononitrate
drug data and news
Isosorbide Mononitrate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Isosorbide Mononitrate | ||
| Brand Names/Synonyms | AHR 4698; CCRIS 1911; Conpin; Conpin Retardkaps; Corangin; Corangin Sr; Duride; Edistol; Elan; Elantan; Elantan Long; Elantan Retard; Epicordin; Etimonis; Fem-Mono; IHD; IS 5MN; ISMN; ISMN AL; ISOSORBIDE MONONITRATE; Imazin; Imdur; Imdur 60; Imdur Durules; Imodur; Imtrate; Ismexin; Ismn Abz; Ismn Apogepha; Ismn Atid; Ismn Basics; Ismn Heumann; Ismn Hexal; Ismn Lannacher; Ismn Stada; Ismo; Ismo-20; Ismotic; Ismox; Isomon; Isomonat; Isomonit; Isopen-20; Isosorbide Mononitrate; Isosorbidi Mononitras [Latin]; Isotrate; Iturol; Medocor; Monicor; Monis; Monisid; Monit; Monit 20; Monizid; Mono Corax; Mono Corax Retard; Mono Mack; Mono-Mack; Mono-Sanorania; Monocedocard; Monoclair; Monocord 20; Monocord 40; Monocord 50 Sr; Monodur Durules; Monoket; Monoket Od; Monoket Retard; Monolong; Monolong 40; Monolong 60; Mononit; Mononit 20; Mononit 40; Mononit Retard 50; Mononitrate d'Isosorbide [French]; Mononitrato de Isosorbida [Spanish]; Monopront; Monosigma; Monosorb; Monosorbitrate; Monosordil; Monotrate; Multitab; Nitex; Nitramin; Olicard; Olicardin; Orasorbil; Pentacard; Pentacard 20; Percorina; Pertil; Plodin; Promocard; Sigacora; Sorbimon; Titarane; Turimonit; UN3251; Uniket; Vasdilat; Vasotrate | ||
| Indication | For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement. | ||
| Mechanism Of Action | Similar to other nitrites and organic nitrates, Isosorbide Mononitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation. | ||
| Isosorbide Mononitrate News (When available) |
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| Dosage Forms | Immediate Release and Extended release tablets | ||
| Drug_Category | Vasodilator Agents; Nitrates and Nitrites; Nitric Oxide Donors; ATC:C01DA14 | ||
| Absorption | 100% | ||
| Interactions |
Drug Interactions for Isosorbide Mononitrate: The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety. Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary. | ||
| Toxicity | vasodilatation, venous pooling, reduced cardiac output, and hypotension, LD50=mg/kg(orally in rat) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 8-nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol | ||
| Chemical Formula | C6H9NO6 | ||
| Molecular Weight | 191.139 g/mol | ||
| Smiles String | C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O | ||
| Melting Point | 88-91°C | ||
| Water Solubility | 1.07E+005 mg/L | ||
| State | white, crystalline, odorless compound | ||
| LogP/Hphobicity | -0.15 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 5 hours | ||
| Protein Binding [%] | 5% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Isosorbide_Mononitrate.html http://www.rxlist.com/cgi/generic/isomono2.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00528 | ||
| CAS Registry Number | 16051-77-7 | ||
| KEGG Compound ID | C07714 | ||
| PubChem ID | SID:9916 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2126559 |
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