|
|
|
|
|
Isosorbide Dinitrate
drug data and news
Isosorbide Dinitrate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Isosorbide Dinitrate | ||
| Brand Names/Synonyms | Dilatrate; Isochron; Isordil; Titradose; Sorbitrate; Dinitrosorbide; Corosorbide; Carvanil; Carvasin; Cedocard; Claodical; Cornilat; Difutrat; Coronex; Flindix; 1,4:3, 6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydrosorbitol 2, 5-dinitrate; 87-33-2; AIDS-125686; AIDS125686; Cardio 10; Cardis; Carvanil; Carvasin; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; Dianhydrosorbitol 2,5-dinitrate; Dilatrate-SR; Dinitrosorbide; Emoper; Flindix; Glucitol, 1,4:3, 6-dianhydro-, dinitrate, D-; Harrical; IBD 20; ISD; ISDN; Ismotic; Iso-Bid; Isoket; Isorbid;; Isordil Tembids; Isosorbide Dinitrate; Isosorbide dinitrate(USAN); Isostat; Isotrate; Korodil; Lomilan; Maycor; Myorexon; Nitrosorbid; Nitrosorbide; Nitrosorbon; Nosim; Resoidan; Rifloc Retard; Rigedal; Sorbangil; Sorbide T.D.; Sorbide nitrate; Sorbide, dinitrate; Sorbidilat; Sorbidnitrate; Sorbislo; Sorbonit; Sorquad; Tinidil; Vascardin; Vasodilat; Vasorbate; Xanyl | ||
| Indication | For the prevention of angina pectoris due to coronary artery disease | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Isosorbide Dinitrate is a moderate- to long-acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure. | ||
| Mechanism Of Action | Similar to other nitrites and organic nitrates, Isosorbide Dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation. | ||
| Isosorbide Dinitrate News (When available) |
For top nutrition,peppers are hot! Mar 2, 2006 Which Water Is Tastiest? Feb 14, 2006 It's time to fertilize the new crop of roses Feb 18, 2006 Risk of Serious Harm and/or Death With Potential IV/SC ... Feb 15, 2006 Hospital in trouble over shorthand Feb 2, 2006 Hospital in trouble over shorthand Feb 2, 2006 Cooler heads studied as treatment for strokes Jan 26, 2006 Temple Gardens Mineral Spa Resort Hotel Jan 29, 2006 Sweet success Jan 10, 2006 New stroke therapy showing promise Jan 27, 2006 Cooler heads may prevail in successfully treating strokes Jan 27, 2006 Phew! Stinky Feet! Jan 12, 2006 Parents hope, pray after baby arrives too early and so tiny Jan 16, 2006 When man alters nature wildlife loses — and wins Dec 8, 2005 Mr. Bubble, Meet the Sandman Nov 30, 2005 Puncture Wounds in the Foot Nov 26, 2005 Ingredients can surprise you Nov 12, 2005 GROUND RULES: The miracle of birth is an understatement in itself Nov 23, 2005 Macrominerals Needed By Cattle Sep 21, 2005 WUSTL Mars team describes water detection at Gusev crater Sep 22, 2005 Turkmen raw materials and commodity exchange functioned full-time ... Oct 3, 2005 Rx for a better PRESCRIPTION Hospital bans doctors from using ... Sep 24, 2005 Krasnodar Territory Sep 13, 2005 | ||
| Dosage Forms | Oral tablet | ||
| Drug_Category | Vasodilator Agents; Nitrates and Nitrites; ATC:C01DA08; ATC:D03AX08 | ||
| Absorption | Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver.The average bioavailability of isosorbide dinitrate is about 25% | ||
| Interactions | DRUG INTERACTIONS The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety. | ||
| Toxicity | reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 4,8-dinitrooxy-2,6-dioxabicyclo[3.3.0]octane | ||
| Chemical Formula | C6H8N2O8 | ||
| Molecular Weight | 236.136 g/mol | ||
| Smiles String | C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-] | ||
| Melting Point | 70°C | ||
| Water Solubility | 1.089 mg/mL | ||
| State | white, crystalline, odorless compound | ||
| LogP/Hphobicity | 1.31 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 1 hour | ||
| Protein Binding [%] | Very low | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/iso1212.shtml http://www.drugs.com/cons/Isosorbide_Dinitrate.html http://www.rxlist.com/cgi/generic2/isodinit.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00455 | ||
| CAS Registry Number | 87-33-2 | ||
| KEGG Compound ID | C07456 | ||
| PubChem ID | SID:149886 | ||
| PharmGKB ID | PA450125 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 670944 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |