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Isoproterenol
drug data and news
Isoproterenol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Isoproterenol | ||
| Brand Names/Synonyms | A 21; Aerolone; Aleudrin; Aleudrine; Aludrin; Aludrine; Asiprenol; Asmalar; Assiprenol; Bellasthman; Bronkephrine; Dihydroxyphenylethanolisopropylamine; Epinephrine Isopropyl Homolog; Euspiran; IPA; Isadrine; Isonorene; Isonorin; Isoprenalin; Isopropydrin; Isopropyladrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol; Isoproterenol Chloride; Isoproterenol Hcl; Isorenin; Isuprel; Isuprel Mistometer; Isupren; L-Isopropylnoradrenaline; L-Isoproterenol; Lomupren; Medihaler-Iso; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine; Neo-Epinine; Neodrenal; Norisodrine; Norisodrine Aerotrol; Novodrin; Proternol; Respifral; Saventrine; Vapo-Iso; WIN 5162 | ||
| Indication | For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. | ||
| Mechanism Of Action | The pharmacologic effects of Isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. | ||
| Isoproterenol News (When available) |
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| Dosage Forms | LIQUID | ||
| Drug_Category | Cardiotonic Agents; Bronchodilator Agents; Sympathomimetic; ATC:R03AC | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Isoproterenol: Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias. The drugs may, however, be administered alternately provided a proper interval has elapsed between doses. ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 4-[1-hydroxy-2-(1-methylethylamino)ethyl]benzene-1,2-diol | ||
| Chemical Formula | C11H17NO3 | ||
| Molecular Weight | 211.258 g/mol | ||
| Smiles String | CC(C)NCC(C1=CC(=C(C=C1)O)O)O | ||
| Melting Point | 170.5 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 1.172 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Isoproterenol.html http://www.rxlist.com/cgi/generic3/isoproterenol.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00182 | ||
| CAS Registry Number | 7683-59-2 | ||
| KEGG Compound ID | C07056 | ||
| PubChem ID | SID:9268 | ||
| PharmGKB ID | PA450121 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 897639 |
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