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Isoflurophate
drug data and news
Isoflurophate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Isoflurophate
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| Brand Names/Synonyms |
DFP; Diflupyl; Diflurophate; Diisopropoxyphosphoryl Fluoride; Diisopropyl Cyanomethylphosphonate,; Diisopropyl Fluoridophosphate; Diisopropyl Fluorophosphate; Diisopropyl Fluorophosphonate; Diisopropyl Phosphofluoridate; Diisopropyl Phosphorofluoridate; Diisopropylfluorfosfat; Diisopropylfluorfosfat [Czech]; Diisopropylfluorophosphoric Acid Ester; Diisopropylfluorphosphorsaeureester; Disiopropyl Fluorophosphonate; Dyflos; EA 1152; Floropryl; Fluorodiisopropyl Phosphate; Fluoropryl; Fluostigmine; Fluropryl; HSDB 2133; Humorsol; Isofluorophate; Isofluorphate; Isoflurophate; Isoflurophosphate; Isopropyl Fluophosphate; Isopropyl Phosphorofluoridate; Neoglaucit; O,O-Diisopropyl Fluorophosphate; PF-3; Phospholine Iodide; Rcra Waste No. P043; Rcra Waste Number P043; T-1703; TL 466 |
| Indication |
For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. |
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Description |
Not Available |
| Pharmacology |
Isoflurophate is used as ocular drops in the treatment of chronic glaucoma. Isoflurophate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Isoflurophate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Isoflurophate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme. |
| Mechanism Of Action |
The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase. |
Isoflurophate News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Antiglaucomic Agents; Ophthalmics; Cholinesterase Inhibitors; Miotics; Protease Inhibitors; ATC:S01EB |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Signs of overdose include increased sweating; loss of bladder control; muscle weakness; nausea, vomiting, diarrhea, or stomach cramps or pain; shortness of breath, tightness in chest, or wheezing; slow or irregular heartbeat; unusual tiredness or weakness; watering of mouth. |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-(fluoro-(1-methylethoxy)phosphoryl)oxypropane |
| Chemical Formula |
C6H14FO3P |
| Molecular Weight |
184.146 g/mol |
| Smiles String |
CC(C)OP(=O)(OC(C)C)F |
| Melting Point |
-82 °C |
| Water Solubility |
1.54E+004 mg/L |
| State |
Liquid |
| LogP/Hphobicity |
1.13 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Isoflurophate.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00763 |
| CAS Registry Number |
55-91-4 |
| KEGG Compound ID |
C00202 |
| PubChem ID |
SID:3502 |
| PharmGKB ID |
PA450107 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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