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Isoflurane
drug data and news
Isoflurane drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Isoflurane | ||
| Brand Names/Synonyms | Aerrane; Compd 469; Compound 469; Ethane; Forane; Forene; Isoflurane; Isoflurane [Usan:Ban:Inn:Jan]; Isofluranum [Inn-Latin] | ||
| Indication | For induction and maintenance of general anesthesia | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. | ||
| Mechanism Of Action | Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor. | ||
| Isoflurane News (When available) |
Dental disease can be dangerous to animals Mar 5, 2006 EEG During Anesthesia Is Not a Linear Random Process Feb 22, 2006 General Anesthesia Does Not Reduce Life Expectancy in Aged Rats Feb 21, 2006 Intravenous Anesthetics Are More Effective than Volatile ... Feb 21, 2006 EEG During Anesthesia Is Not a Linear Random Process Feb 21, 2006 Sustained Hypertension at Reperfusion of the Transplanted Kidneys ... Feb 21, 2006 The Morning Read: The height of care Feb 4, 2006 A Strange Place to Find a Cable Tie Feb 14, 2006 Going Under Feb 6, 2006 An Evaluation of the Insertion and Function of a New Supraglottic ... Feb 14, 2006 Blood work needed before anesthesia Feb 2, 2006 Birds-only veterinarian uses high-tech tools and a gentle touch Feb 8, 2006 Going Under Feb 6, 2006 Anesthetic preconditioning as the alternative to ischemic ... Jan 23, 2006 Blood work needed before anesthesia Feb 2, 2006 Department of Physiology and Pharmacology, James Cook University ... Jan 23, 2006 Routine Inhaled Induction in Adults: A Safe Practice? Jan 29, 2006 Isoflurane Prevents Platelets from Enhancing Neutrophil-Induced ... Nov 8, 2005 Holiday Wish List Dec 9, 2005 Surgical strike Nov 25, 2005 Morphine Enhances Isoflurane-Induced Postconditioning Against ... Sep 30, 2005 The Effect of Anesthesia by Diethyl Ether or Isoflurane on ... Sep 30, 2005 Species-Specific Differences in Response to Anesthetics and Other ... Sep 30, 2005 Tetsuya Kakutani, MD , Koji Ogawa, MD , Shizue Iwahashi, MD ... Sep 30, 2005 Recovery Room Delirium Predicts Postoperative Delirium After Hip ... Oct 3, 2005 Nitrous Oxide Does Not Increase Postop Infection Risk Sep 22, 2005 Temperatures in Soda Lime During Degradation of Desflurane ... Aug 22, 2005 Isoflurane-Induced Neuronal Degeneration: An Evaluation in ... Aug 22, 2005 Tutorial: Context-Sensitive Decrement Times for Inhaled ... Aug 22, 2005 Notes On Whelping And Raising A Litter Aug 16, 2005 The Effect of Different Isoflurane-Fentanyl Dose Combinations on ... Jul 21, 2005 Postischemic Nitrous Oxide Alone Versus Intraischemic Nitrous ... Jul 21, 2005 Postischemic Nitrous Oxide Alone Versus Intraischemic Nitrous ... Jul 21, 2005 The Influence of Gender on Loss of Consciousness with Sevoflurane ... Jul 21, 2005 ß3-Containing Gamma-Aminobutyric Acid A Receptors Are Not Major ... Jul 21, 2005 The -Subunit Governs the Susceptibility of Recombinant ... Jul 21, 2005 Volatile substance abuse deaths drop in the UK Jul 23, 2005 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Anesthetics; General Anesthetics; ATC:N01AB06 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Isoflurane: Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants, and MAC (minimum alveolar concentration) is reduced by concomitant administration of N2O. See CLINICAL PHARMACOLOGY. | ||
| Toxicity | LC50=15300 ppm/3hrs (inhalation by rat) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane | ||
| Chemical Formula | C3H2ClF5O | ||
| Molecular Weight | 184.492 g/mol | ||
| Smiles String | C(C(F)(F)F)(OC(F)F)Cl | ||
| Melting Point | 49 oC (BP) | ||
| Water Solubility | insoluble | ||
| State | Liquid | ||
| LogP/Hphobicity | 2.677 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Minimal | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Isoflurane.html http://www.rxlist.com/cgi/generic3/isoflurane.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00212 | ||
| CAS Registry Number | 26675-46-7 | ||
| KEGG Compound ID | C07518 | ||
| PubChem ID | SID:175428 | ||
| PharmGKB ID | PA450106 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2241315 |
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