Ipratropium drug data and news

Ipratropium drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Ipratropium
Brand Names/Synonyms Aerovent; Apo-Ipravent; Apovent; Atronase; Atrovent; Atrovent Aerosol; Atrovent Hfa; Atrovent Nasal; Bitrop; Disne-Asmol; IPRATROPIUM; Ipatropium Bromide; Ipratropium; Ipratropium Bromide; Ipravent; Ipvent; Kendral-Ipratropium; N-Isopropylatropine; Narilet; Rhinotrop; Rhinovent; Rinatec; Rinoberen; Rinovagos; Vagos
Indication For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema
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Description Not Available
Pharmacology Ipratropium bromide, a synthetic ammonium compound structurally similar to atropine, is used as a bronchodilator in the management of cholinergic-mediated bronchospasm associated with chronic obstructive pulmonary disease and in the treatment of rhinorrhea associated with the common cold or with allergic or nonallergic seasonal rhinitis.
Mechanism Of Action Ipratropium bromide is an anticholinergic agent. It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle.
Ipratropium News
(When available)

Nebulizer-Associated Anisocoria  Mar 1, 2006
She received oxygen and nebulized albuterol (salbutamol) and ipratropium bromide through a face mask that was attached to a noninvasive bilevel positive-airway ... - New England Journal of Medicine (subscription),

Generic Pharmaceutical Association  Feb 17, 2006
...albuterol). Ipratropium, beclomethasone and numerous other products are on the market without patent or exclusivity protection. ... - FDA.gov

James Le Fanu investigates some pillow ploys for runny noses  Jan 9, 2006
...person, is usually due to an imbalance in the nerves that control the blood flow to the nasal lining, and will respond to the nasal spray Ipratropium Bromide. - Telegraph.co.uk,

Breathe Easier!  Jan 22, 2006
Another drug in this class, called ipratropium bromide, is formulated for human patients and can be administered by aerosol inhalation. ... - TheHorse.com,

Health Tip: Whether Acute Or Chronic, Bronchitis Hurts  Dec 8, 2005
...reduce coughing. Cough medicines, antibiotics and bronchodilators, such as albuterol and ipratropium, may also be necessary. Patients ... - Forbes

No Justification for Deep Cut in 2006 Medicare Dispensing Fee for ...  Nov 13, 2005
Two commonly dispensed drugs used in inhalation therapy are albuterol sulfate and ipratropium bromide, which are prescribed to treat diseases like chronic ... - Medical News Today (press release),

Diagnosing Airway Disease  Dec 2, 2005
Effect of salbutamol and ipratropium bromide on airway calibre and bronchial reactivity in asthma and chronic bronchitis. Eur Respir J. 1991;4:415-420. ... - Medscape (subscription)

Generic Deluge  Nov 14, 2005
DuoNeb, which contains albuterol and ipratropium, was approved by FDA in 2001 for the treatment of bronchospasm associated with chronic obstructive pulmonary ... - Med Ad News (subscription),

Asthma and COPD Patients Find New Soft Mist Inhaler Highly ...  Sep 19, 2005
...show that patients with asthma and chronic obstructive pulmonary disease (COPD) are highly satisfied with Berodual ® Respimat ® (ipratropium bromide/fenoterol ... - PharmaLive.com (press release),

44% of Homecare Pharmacies Will Stop Providing Inhalation Drug ...  Oct 3, 2005
...fee schedule issued in August, CMS proposed an 89 percent reimbursement cut for the drugs, using the ASP formula, for albuterol sulfate and ipratropium bromide ... - Medical News Today (press release),

Head-to-Head Study Shows COPD Patients Achieve Significantly ...  Sep 18, 2005
...air trapping).(2,10) Spiriva(R) also demonstrated superior and sustained improvements in lung function (FEV1) over Atrovent(R) (ipratropium bromide) Inhalation ... - PR Newswire UK (press release),

Head-to-head Study Shows COPD Patients Achieve Significantly ...  Sep 19, 2005
2,10 Spiriva ® also demonstrated superior and sustained improvements in lung function (FEV 1 ) over Atrovent ® (ipratropium bromide) Inhalation Aerosol, a ... - PharmaLive.com (press release),

Merck KGaA Establishes International Respiratory Medicines ...  Sep 19, 2005
Its best-known products are DuoNeb(R), an Ipratropium/Salbutamol nebule for the treatment of COPD, and EpiPen(R), an auto-injector for the emergency treatment ... - PharmaLive.com (press release),

Nwadiuko on asthma requirements (2)  Sep 5, 2005
Ipratropium, which relaxes the muscles that tightened around the airways. It does not act as quickly as beta2-agonist medicines do. ... - Daily Independent,

American Association for Homecare Opposes Any Cut to Dispensing ...  06 Aug 2005
...schedule issued last August, CMS proposed an 89 percent reimbursement cut for the drugs, using the ASP formula, for albuterol sulfate and ipratropium bromide. ... - I-Newswire.com (press release)

Update in General Internal Medicine  Aug 5, 2005
One-year cost- effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease. Eur Respir J. 2004;23:241-9. [PMID: 14979498]. ... - RedNova.com

FDA Advisory Committee  Jul 14, 2005
FDA’s Pulmonary-Allergy Drugs Advisory Committee reached a split decision on whether Boehringer Ingelheim’s Combivent (albuterol/ipratropium) should remain ... - FDA Advisory Committee

Merck sees turnover rise across chemicals, pharma  Jul 25, 2005
Contributing to the success was its bestselling product in the US, the DuoNeb (albuterol and ipratropium) inhaler for treating chronic obstructive pulmonary ... - in-PharmaTechnologist

Photo: Edwina Pickles  Jul 6, 2005
The Gap: Although ipratropium bromide is a useful addition for drug treatment of severe asthma, it does not help mild to moderate asthma - however, it is used ... - Sydney Morning Herald (subscription)

FDA Committee To Decide If Azmacort, Alupent, Intal Remain " ...  Jul 13, 2005
...and Kos Azmacort (triamcinolone); cromones from King, Intal (cromolyn) and Tilade (nedocromil); and Boehringer Ingelheim’s Combivent (albuterol/ipratropium). ... - FDA Advisory Committee

Drug Company Settles Price-Fixing Case in Connecticut  Jul 20, 2005
The company has promised to donate more than 2 million vials of DuoNeb, Albuterol and Ipratropium Bromide -- all treatments for respiratory ailments such as ... - RedNova.com <**results**>

Photo: Edwina Pickles  Jul 6, 2005
The Gap: Although ipratropium bromide is a useful addition for drug treatment of severe asthma, it does not help mild to moderate asthma - however, it is used ... - Sydney Morning Herald (subscription)

Changes in Inhaler Devices for Asthma And COPD  Jun 19, 2005
Ipratropium (Atrovent Inhalation Aerosol), a CFC-propelled pMDI, is indicated for maintenance treatment of bronchospasm associated with COPD. ... - RedNova.com

Ignorance of doctors is risking lives  Jun 24, 2005
Evidence shows ipratropium bromide - a drug which reduces mucus secretion - is useful in the treatment of severe asthma, but not in the treatment of mild or ... - Sydney Morning Herald (subscription),

Changes in Inhaler Devices for Asthma And COPD  Jun 19, 2005
Ipratropium (Atrovent Inhalation Aerosol), a CFC-propelled pMDI, is indicated for maintenance treatment of bronchospasm associated with COPD. ... - RedNova.com,

Ignorance of doctors is risking lives  Jun 24, 2005
Evidence shows ipratropium bromide - a drug which reduces mucus secretion - is useful in the treatment of severe asthma, but not in the treatment of mild or ... - Sydney Morning Herald (subscription),

Chronic Obstructive Pulmonary Disease  Jun 8, 2005
An abstract in the British Veterinary Journal, printed in September 1997, reported on the use of ipratropium bromide, a bronchodilator, in treating horses with ... - TheHorse.com,

DATAMONITOR: Novel Combinations Breathe Life into COPD Market  Apr 26, 2005
Inhaled short-acting bronchodilators, such as Boehringer Ingelheim’s Atrovent (ipratropium bromide) and GSK’s Ventolin (salbutamol/albuterol), are ... - PharmaLive.com

/FIRST ADD -- NYTU041B -- Pfizer Inc Earnings/  Apr 19, 2005
Spiriva also provides sustained and significant improvements in lung function compared to ipratropium, the currently recommended first- line therapy outlined ... - PR Newswire

Boehringer Ingelheim reports strong 2004  Apr 7, 2005
Revenues rose more than 10 per cent to just under €8.2 billion, with growth driven by surging sales for Spiriva (ipratropium bromide), Boehringer’s drug ... - in-PharmaTechnologist,

Texas Goes After Big Pharma  Mar 4, 2005
The state claims that Roxane knowingly inflated its prices on about 18 different drugs, including the asthma drug ipratropium bromide, and continued doing so ... - The Texas Observer,

The Effects of a Smoking Cessation Program on Long-Term Survival ...  Feb 14, 2005
...in a large study called the Lung Health Study, which examined whether a smoking cessation program and treatment with a drug called ipratropium could prevent ... - Annals of Internal Medicine

Dosage Forms AEROSOL (WITH PROPELLANTS); LIQUID; METERED-DOSE (AEROSOL); METERED-DOSE (PUMP); SOLUTION
Drug_Category Bronchodilator Agents; Cholinergic Antagonists; Antimuscarinics; Antispasmodics; ATC:R01AX03; ATC:R03BB01
Absorption Inhalation (local)-minimal; Nasal-rapid and minimal
Interactions Interactions for Ipratropium:

ATROVENT Inhalation Aerosol has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, and steroids, commonly used in the treatment of chronic obstructive pulmonary disease. With the exception of albuterol, there are no formal studies fully evaluating the interaction effects of ATROVENT Inhalation Aerosol and these drugs with respect to effectiveness.

Anticholinergic agents: Although ipratropium bromide is minimally absorbed into the systemic circulation, there is some potential for an additive interaction with concomitantly used anticholinergic medications. Caution is therefore advised in the coadministration of ATROVENT Inhalation Aerosol with other anticholinergic-containing drugs.

Toxicity LD50=1001mg/kg(orally in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name [8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]oct-3-yl]3-hydroxy-2-phenyl-propanoate
Chemical Formula C20H30NO3
Molecular Weight 332.457 g/mol
Smiles String CC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C
Melting Point 230-232°C
Water Solubility Freely soluble
State white to off-white crystalline substance
LogP/Hphobicity Not Available
Isoelectric Point Not Available
Biotransformation Liver
Half Life ~2 hours
Protein Binding [%] minimally (0 to 9% in vitro) bound to plasma albumin and a1-acid glycoproteins
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Ipratropium.html
http://www.rxlist.com/cgi/generic/ipratrop.htm
Drug Type Approved Drug
Accession No APRD00537
CAS Registry Number 60205-81-4
KEGG Compound ID C07052
PubChem ID SID:183666
PharmGKB ID PA450082
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2240072

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