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Interferon gamma-1b
drug data and news
Interferon gamma-1b drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Interferon gamma-1b | ||
| Brand Names/Synonyms | Interferon gamma precursor;IFN-gamma;Immune interferon; Actimmune (InterMune Inc) | ||
| Indication | For treatment of Chronic granulomatous disease, Osteopetrosis | ||
| Sponsored links | Description | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. | |
| Pharmacology | IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon gamma-1b may prevent excessive scarring. | ||
| Mechanism Of Action | Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes. | ||
| Interferon gamma-1b News (When available) |
PR Newswire (press release), HCV) infections. The pulmonology portfolio includes Actimmune(R) (interferon gamma-1b), pirfenidone and research programs. Actimmune ... InterMune Announces Divestiture of Oritavancin Dec 27, 2005 Yahoo! News (press release) HCV) infections. The pulmonology portfolio includes Actimmune® (interferon gamma-1b), pirfenidone and research programs. Actimmune ... -> InterMune Announces First Quarter Financial Results and Business ... Apr 27, 2006 InterMune to Present at the Deutsche Bank 2006 Health Care ... Apr 26, 2006 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Antiviral Agents; Immunomodulatory Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | Human interferon gamma-1b | ||
| Chemical Formula | C761H1206N214O225S6 | ||
| Molecular Weight | 17145.6 | ||
| Smiles String | Not Available | ||
| Melting Point | 61 oC (Beldarrain, A. et al., Biochemistry 38:7865-7873 (1999)) | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.823 | ||
| Isoelectric Point | 9.54 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Interferon_gamma-1b.html | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00017 | ||
| CAS Registry Number | 82115-62-6; 98059-61-1 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA450040 | ||
| SwissProt ID | IFNG_HUMAN (P01579) | ||
| GenBank ID | X13274 | ||
| Drug ID Number [DIN] | Not Available |
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