Interferon beta-1b drug data and news

Interferon beta-1b drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Interferon beta-1b

Brand Names/Synonyms

Interferon beta precursor;IFN-beta;Fibroblast interferon; Betaseron (Chiron Corp)

Indication

For treatment of relapsing/remitting multiple sclerosis

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Description

Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD

Pharmacology

Interferon beta upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Type I interferons also induce the synthesis of several key antiviral mediators including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin, neopterin and protein kinase R.

Mechanism Of Action

Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.

Interferon beta-1b News
(When available)

Pfizer CEO Earned Nearly $16 MLN in 2005 and Chiron Confirms ... Feb 27, 2006
...agreement with Chiron to purchase or lease all assets used by Chiron in the manufacture for Schering of BETASERON® interferon beta-1b products and all ... - Financial News USA (press release),

New Survey of Neurologists Sheds Light on Trends for MS Therapy Feb 16, 2006
General Information The Image of MS and the neurologist survey are sponsored by Berlex, Inc., marketers of Betaseron® (interferon beta-1b). ... - PharmaLive.com (press release),

Schering AG: Set for Betaseron Buy-Back Boost Feb 22, 2006
Schering has announced its intention to end its supply relationship with Chiron, its US marketing partner for Betaseron (interferon beta-1b). ... - International News Service,

Clorox: Worst over for rising commodity costs Feb 24, 2006
In another announcement, Chiron said Schering AG agreed to purchase its assets used to manufacture Betaseron interferon beta-1b products to treat multiple ... - San Jose Mercury News,

Schering to buy some Chiron assets Feb 24, 2006
...said Friday that Schering AG agreed to purchase its assets used to manufacture Betaseron interferon beta-1b products to treat multiple sclerosis. ... - BusinessWeek

Schering to buy or lease all Chiron assets used to produce ... Feb 27, 2006
...joint collaboration agreement to purchase or lease all assets used by Chiron in the manufacture for Schering of MS drug Betaseron interferon beta-1b products. ... - Forbes

Chiron Confirms Proposed Purchase of BETASERON Assets by Schering ... Feb 24, 2006
...agreement with Chiron topurchase or lease all assets used by Chiron in the manufacture forSchering of BETASERON(R) interferon beta-1b products and ... - Finanzen.net,

Schering says 2005 was a 'record year Feb 20, 2006
Schering's top-selling product, the multiple sclerosis drug Betaferon/Betaseron (interferon beta-1b) also climbed 12% in the quarter to 240 million euros, an ... - Pharma Times (subscription),

Berlex Files Application for Use of Betaseron in Patients with a ... Feb 23, 2006
...of a supplemental biologics license application (sBLA) requesting an expanded label for its multiple sclerosis (MS) therapy, Betaseron(R) (interferon beta-1b). ... - PharmaLive.com (press release),

Berlex Files Application for Use of Betaseron in Patients with a ... Feb 23, 2006
...of a supplemental biologics license application (sBLA) requesting an expanded label for its multiple sclerosis (MS) therapy, Betaseron® (interferon beta-1b). ... - Yahoo! News (press release)

Image of Multiple Sclerosis Captured Through Photographic Exhibit ... Feb 2, 2006
...and, if diagnosed, to start treatment as soon as possible." Since beginning treatment two-and-a-half years ago with Betaseron® (interferon beta-1b), one of ... - Yahoo! News (press release)

Dosage Forms

LIQUID;POWDER FOR SOLUTION

Drug_Category

Antiviral Agents; Immunomodulatory Agents; unclassified therapeutic agents (92:00.00)

Absorption

Not Available

Interactions

Not Available

Toxicity

Not Available

Organisms Affected

Not Available

Chemical IUPAC Name

Human interferon beta

Chemical Formula

C908H1408N246O253S6

Molecular Weight

20011

Smiles String

Not Available

Melting Point

Not Available

Water Solubility

Not Available

State

Transparent, slightly viscous, aqueous liquid

LogP/Hphobicity

-0.447

Isoelectric Point

9.02

Biotransformation

Not Available

Half Life

Not Available

Protein Binding [%]

Not Available

RxList Link

RXlist

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Drug Reference

http://www.rxlist.com/cgi/generic/interferon_beta.htm

Drug Type

Approved Drug

Accession No

BIOD00078

CAS Registry Number

96778-78-8; 145155-23-3

KEGG Compound ID

Not Available

PubChem ID

Not Available

PharmGKB ID

PA10114

SwissProt ID

IFNB_HUMAN (P01574)

GenBank ID

V00534

Drug ID Number [DIN]

2169649