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Infliximab
drug data and news
Infliximab drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Infliximab | ||
| Brand Names/Synonyms | Ig gamma-1 chain C region; Remicade (Centocor Inc) | ||
| Indication | For treatment of Crohn's disease, psoriasis, rheumatoid arthitis and ankylosing spondylitis | ||
| Sponsored links | Description | Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion | |
| Pharmacology | Used in the treatment of auto-immune disorders such as Crohn'€™s disease and rheumatoid arthritis. Infliximab binds to tumor necrosis factor alpha (TNFa) and inhibits binding of TNFa with its receptors. This reduces production of pro-inflammatory cytokines such as interleukins (IL) 1 and 6. This also limits leukocyte migration and expression of adhesion molecules by endothelial cells and leukocytes. Infliximab also limits the activation of neutrophil and eosinophil functional activity, reduces production of tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Infliximab decreases synovitis and joint erosions in collagen-induced arthritis and allows eroded joints to heal. | ||
| Mechanism Of Action | Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with its receptors. Infliximab does not neutralize TNFb (lymphotoxin a), a related cytokine that utilizes the same receptors as TNFa | ||
| Infliximab News (When available) |
Analysis: Remicade works for psorasis 07 Mar 2006 Infliximab for Crohn’s Disease Not Associated with Increased ... Feb 8, 2006 REMICADE(R) Phase 3 Data Show Rapid and Significant Improvement ... Mar 3, 2006 REMICADE(R) Phase 3 Data Show Rapid and Significant Improvement ... Mar 3, 2006 FDA Approves Rituxan for Refractory Rheumatoid Arthritis Mar 1, 2006 Genentech/Biogen Idec: Rituxan further expands its options Mar 2, 2006 FDA clears Rituxan for rheumatoid arthritis Mar 1, 2006 Genentech, Biogen Idec Gain Approval Of Rituxan In RA Mar 1, 2006 Three-year studies on a novel therapy for rheumatoid arthritis ... Feb 22, 2006 BAMBOO SPINE, A SPECIAL KIND OF ARTHRITIS Feb 25, 2006 Rheumatic Diseases Remain a Significant Cause of Chronic Illness ... Feb 22, 2006 Better Fix For Rheumatoid Arthritis Feb 16, 2006 American Journal of Clinical Nutrition, Vol. 83, No. 2, 475S-483S ... Feb 17, 2006 Inflammatory Diseases - Both Chronic Diseases, Such as Rheumatoid ... Feb 1, 2006 Novel drug treatments help against gout and colitis Jan 31, 2006 | ||
| Dosage Forms | POWDER FOR SOLUTION | ||
| Drug_Category | Immunomodulatory Agents; Immunosuppresants; unclassified therapeutic agents (92:00.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Chimeric mouse/human anti-TNF-alpha antibody (cA2) | ||
| Chemical Formula | C6428H9912N1694O1987S46 >Mouse-Human chimeric chain 1 Anti-TNF alpha VL >Mouse-Human chimeric chain 2 Anti-TNF alpha VH >Mouse-Human chimeric chain 2 Anti-TNF alpha VL | ||
| Molecular Weight | 144190.3 | ||
| Smiles String | Not Available | ||
| Melting Point | 61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.441 | ||
| Isoelectric Point | 8.25 | ||
| Biotransformation | Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production | ||
| Half Life | 9.5 days | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Infliximab.html http://www.rxlist.com/cgi/generic3/infliximab.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00004 | ||
| CAS Registry Number | 331731-18-1 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA452639 | ||
| SwissProt ID | IGHG1_HUMAN (P01857) | ||
| GenBank ID | J00228 | ||
| Drug ID Number [DIN] | 2244016 |
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