Indinavir drug data and news

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A different kind of prescription  Mar 3, 2006
HIV patients on the protease inhibitor indinavir, for example, saw the level of the drug in their systems suppressed when they took the mild depression ... - Baltimore Sun,

CROI: Low rates of resistance seen in Staccato trial of CD4-guided ...  Feb 26, 2006
...resistant virus contained two mutations in the protease gene (M36I and M46I), which would result in resistance to the protease inhibitor indinavir (Crixivan). ... - Aidsmap,

Boehringer Ingelheim Announces 48-week Results from Aptivus ...  Feb 10, 2006
CPIs included lopinavir, saquinavir, amprenavir and indinavir. ... The comparator PIs were lopinavir, indinavir, saquinavir and amprenavir. ... - DG News

Gilead Sciences Welcomes Guidance From Nice On Treatment Of ...  Feb 22, 2006
At doses of adefovir dipivoxil from 60 mg to 120 mg, no interactions with zidovudine, nelfinavir, nevirapine, indinavir, efavirenz, delaviridine, or lamivudine ... - Medical News Today (press release),

Schering-Plough Presents Vicriviroc Clinical Study Results at 13th ...  Feb 10, 2006
...researchers. Vicriviroc was studied in combination with ritonavir-boosted atazanavir, fosamprenavir, indinavir, nelfinavir, and saquinavir. ... - DG News

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Protease Inhibitors (PIs), which include amprenavir (Agenerase), nelfinavir (Viracept), saquinavir (Fortavase), indinavir (Crixivan), ritonavir (Norvir ... - Express Pharma Pulse,

Advances in First-Line and "Switch" Antiretroviral Strategies for ...  Feb 2, 2006
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic ... - Medscape (subscription)

Boehringer Ingelheim Announces 48-week Results from Aptivus(R) ...  09 Feb 2006
CPIs included lopinavir, saquinavir, amprenavir and indinavir. ... The comparator PIs were lopinavir, indinavir, saquinavir and amprenavir. ... - PR Newswire (press release),

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Protease Inhibitors (PIs), which include amprenavir (Agenerase), nelfinavir (Viracept), saquinavir (Fortavase), indinavir (Crixivan), ritonavir (Norvir ... - Express Pharma Pulse,

Advances in First-Line and "Switch" Antiretroviral Strategies for ...  Feb 2, 2006
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic ... - Medscape (subscription)

Reduce platelet aggregation, blood clotting, inflammation, nervous ...  Jan 12, 2006
It cannot be used together with the anti-Aids drug indinavir, or cyclosporine, used to treat some auto immune disease like systemic lupus erythematosis and to ... - Health24.com,

HIV Virus Emerging Drug Resistant In UK, Prompting Fear Of A ...  Nov 18, 2005
The currently available drugs are Zidovudine, Stavudine, Lamivudine, Abacavir, Indinavir, Efavirenz, Nevirapine and Didanosine. ... - MedIndia,

The overuse of Tamiflu in treating avian flu  Dec 2, 2005
Three or four antiretrovirals (ao zidovudine, didanosine, nefirapine, and indinavir) have been contributing modestly to the treatment of HIV-positive patients. ... - Jakarta Post,

Tipranavir continues to show benefit in treatment-experienced ...  Nov 30, 2005
This consisted of the best option, based on resistance testing, from a choice of ritonavir-boosted lopinavir (Kaletra), indinavir (Crixivan), saquinavir ... - Aidsmap,

Interleukin-2 has short-lived negative impact on quality of life  Dec 1, 2005
All of the patients took an anti-HIV drug combination of indinavir (Crixivan) and two nucleoside reverse transcriptase inhibitors (NRTIs) for twelve weeks. ... - Aidsmap,

Study of nucleoside-sparing regimens stopped early due to high ...  Nov 22, 2005
PI) regimens. The NNRTI and PI drugs were restricted to boosted efavirenz or nevirapine plus boosted lopinavir or indinavir. All ... - Aidsmap,

APTIVUS(R) Sustains Convincing Anti-HIV  Nov 21, 2005
...comparator protease inhibitors (PIs) that included lopinavir/r (Kaletra(R)), amprenavir/r (Agenerase(R)), saquinavir/r (Invirase(R)) and indinavir/r (Crixivan(R ... - APA OTS (Pressemitteilung),

Once-daily boosted saquinavir has low blood levels when used with ...  Nov 11, 2005
...inhibitors, and it is known that rifampicin can reduce blood levels of “unboosted� protease inhibitors, such as saquinavir, indinavir, nelfinavir and ... - Aidsmap,

Boehringer Ingelheim Announces 48-Week Results from Aptivus(R) ...  Nov 21, 2005
...response based on resistance testing. The comparator PIs were lopinavir, indinavir, saquinavir and amprenavir. In addition, patients in ... - Yahoo! News (press release)

Aptivus Sustains Convincing Anti-HIV Effect Through 48 Weeks  Nov 21, 2005
...comparator protease inhibitors (PIs) that included lopinavir/r (Kaletra®), amprenavir/r (Agenerase®), saquinavir/r (Invirase®) and indinavir/r (Crixivan ... - PharmaLive.com (press release),

Infection with harmless hepatitis G doesn't mean that HIV ...  Nov 24, 2005
...infection. The MaxCmin 1 trial was designed to compare the safety and efficacy of ritonavir-boosted saquinavir and indinavir. The ... - Aidsmap,

Lab studies show that protein in St John's wort can inhibit HIV ...  31 Oct 2005
...usually bought over the counter without medical advice, has been shown to interfere with the way the body metabolises the protease inhibitor indinavir (Crixivan ... - Aidsmap,

Long-Term Indinavir Treatment Keeps HIV Under Control at 156 Weeks ...  Oct 11, 2005
SAN FRANCISCO, CA -- October 11, 2005 -- Most patients who were treated with an antiretroviral regimen that included the protease inhibitor indinavir were able ... - DG News

EU commission approves Aptivus® for the treatment of HIV  Oct 26, 2005
...other commonly used ritonavir-boosted PIs, including Kaletra® (lopinavir/r), Invirase® (saquinavir), Agenerase® (amprenavir) and Crixivan® (indinavir).1. ... - Biotech Intelligence (press release),

EU Commission Approves Aptivus (Tipranavir) for Treatment of HIV  Oct 26, 2005
...commonly used ritonavir-boosted PIs, including Kaletra(R) (lopinavir/r), Invirase(R) (saquinavir), Agenerase(R) (amprenavir) and Crixivan(R) (indinavir).1. ... - DG News

HIV drugs do not cause body fat changes  Sep 29, 2005
Known by names such as "Crix belly" after the drug Crixivan (indinavir; Merck), such body fat increases are often regarded as an adverse effect of anti-HIV ... - myDNA.com,

Four year treatment break does not reverse fat loss, says case ...  Oct 11, 2005
HIV in 1989 and in July 1997, when her CD4 cell count was below 100 cells/mm 3 started potent anti-HIV therapy with a regimen comprising d4T, 3TC and indinavir ... - Aidsmap,

Merck Announces New Unisured Discount Program Targeted to More ...  Oct 7, 2005
...programs for a number of other prescription medicines, including CANCIDAS(R) (caspofungin acetate) for Injection, CRIXIVAN(R) (indinavir sulfate) Capsules, and ... - Hispanic PR Wire (press release),

Switch to Atazanavir Normalizes Aberrant Cholesterol Values ...  Oct 13, 2005
...loads and mean CD4 counts greater than 550 cells/mL while on a HAART regimen that included protease inhibitors - nelfinavir, amprenavir, indinavir or lopinavir ... - DG News

Long-Term Indinavir Treatment Keeps HIV Under Control at 156 Weeks ...  11 Oct 2005
SAN FRANCISCO, CA -- October 11, 2005 -- Most patients who were treated with an antiretroviral regimen that included the protease inhibitor indinavir were able ... - DG News

Four year treatment break does not reverse fat loss, says case ...  11 Oct 2005
HIV in 1989 and in July 1997, when her CD4 cell count was below 100 cells/mm 3 started potent anti-HIV therapy with a regimen comprising d4T, 3TC and indinavir ... - Aidsmap,

HIV drugs do not cause body fat changes  Sep 29, 2005
Known by names such as "Crix belly" after the drug Crixivan (indinavir; Merck), such body fat increases are often regarded as an adverse effect of anti-HIV ... - myDNA.com,

Merck Announces New Unisured Discount Program Targeted to More ...  Oct 7, 2005
...programs for a number of other prescription medicines, including CANCIDAS(R) (caspofungin acetate) for Injection, CRIXIVAN(R) (indinavir sulfate) Capsules, and ... - Hispanic PR Wire (press release),

Genetic test can help predict who will develop hyperbilirubinaemia  Sep 13, 2005
...to develop hyperbilirubinaemia, a potential side-effect of treatment with the protease inhibitors atazanavir (Reyataz) and indinavir (Crixivan), according to a ... - Aidsmap,

FDA Approvals: Naglazyme, Trizivir, Levaquin  Aug 11, 2005
...week data from a multicenter, double-blind study in which 562 therapy-naive adults were randomized to receive either abacavir sulfate or indinavir sulfate in ... - Medscape (subscription)

HAART is not reducing risk of anal cancer in gay men  Aug 28, 2005
Lamivudine (3TC, Epivir; 59%) was the most commonly used, currently taken antiretroviral, followed by stavudine (d4T, Zerit; 52%), indinavir (Crixivan 26%) and ... - Aidsmap,

US men's study finds cumulative NRTI use, but not PIs or NNRTIs ...  Aug 24, 2005
The most commonly prescribed PI, indinavir (Crixivan) (26%), was the only PI associated with any measure of insulin resistance - increased odds of ... - Aidsmap,

Anti-HIV drugs linked with nerve damage  Aug 26, 2005
Protease inhibitors attack HIV in a different way than dideoxynucleosides. Those linked to neuropathy were indinavir, saquinavir and ritonavir. ... - Macleans,

Counterfeit Medicines - No Problem Yet  Aug 11, 2005
...the mechanisms that are in place was the development of Ginovir-3D, a generic medicine containing Zidovudine in combination with Lamivudine and Indinavir. ... - AllAfrica.com,

Indian Generic Drug Firm Ranbaxy Announces Seven Antiretroviral ...  Aug 16, 2005
Ranbaxy in November 2004 voluntarily removed its drugs -- including indinavir, lamivudine, nevirapine, stavudine and zidovudine tablets, as well as two ... - Kaiser network.org,

Timeline: AIDS in America  Aug 13, 2005
...inhibitor class. It also approves protease inhibitors Ritonavir (Norvir, by Abbott) and indinavir (Crixivan, by Merck). * FDA approves ... - Knoxville News Sentinel (subscription),

You've done it. What now?  06 Aug 2005
...days after an HIV exposure. In some circumstances, a third drug such as indinavir is added to this treatment. A person who has had ... - Health24.com

Tipranavir, a powerful treatment option for HIV-positive treatment ...  Jul 31, 2005
Aptivus versus established ritonavir-boosted comparator protease inhibitors (PIs), which included lopinavir/r, amprenavir/r, saquinavir/r or indinavir/r. PIs ... - RxPG NEWS

COMUNICADO (I): Positive Opinion in Europe for Tipranavir  Jul 28, 2005
APTIVUS versus established ritonavir-boosted comparator protease inhibitors (PIs), which included lopinavir/r, amprenavir/r, saquinavir/r or indinavir/r. PIs ... - Europa Press

IAS: Have we prematurely discarded triple NRTI regimens?  Jul 27, 2005
He concluded that although not all triple NRTI-regimens are alike, even the most potent are only comparable to unboosted indinavir, nelfinavir and amprenavir ... - Aidsmap

Indinavir is an inhibitor of the cytochrome P450 isoform CYP3A4. Coadministration of CRIXIVAN and drugs primarily metabolized by CYP3A4 may result in increased plasma concentrations of the other drug, which could increase or prolong its therapeutic and adverse effects.

Indinavir is metabolized by CYP3A4. Drugs that induce CYP3A4 activity would be expected to increase the clearance of indinavir, resulting in lowered plasma concentrations of indinavir. Coadministration of CRIXIVAN and other drugs that inhibit CYP3A4 may decrease the clearance of indinavir and may result in increased plasma concentrations of indinavir.