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Ibuprofen
drug data and news
Ibuprofen drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Ibuprofen | ||
| Brand Names/Synonyms | Actiprofen; Adran; Advil; Advil Liqui-Gels; Amersol; Amibufen; Anco; Andran; Anflagen; Apo-Ibuprofen; Apsifen; Apsifen-F; Artril 300; Bluton; Brufanic; Brufen; Brufort; Buburone; Butylenin; Cap-Profen; Children's Advil; Children's Elixsure; Children's Ibuprofen; Children's Motrin; Codral; Dolgin; Dolgirid; Dolgit; Dolo-Dolgit; Dolocyl; Ebufac; Emodin; Epobron; Femadon; Fenbid Spansule; Haltran; IP-82; Ibu; Ibu-Attritin; Ibu-Slo; Ibu-Tab; Ibu-Tab 200; Ibufen; Ibumetin; Ibuprin; Ibuprocin; Ibuprofen; Ibuprohm; Ibutid; Ifen; Inabrin; Inoven; Junior Strength Advil; Junior Strength Ibuprofen; Junior Strength Motrin; Lamidon; Lebrufen; Lidifen; Liptan; Medipren; Midol; Midol 200; Motrin; Mynosedin; Napacetin; Nobfelon; Nobfen; Nobgen; Novogent N; Novoprofen; Nuprin; Nurofen; P-Isobutylhydratropic Acid; Pantrop; Para-Isobutylhydratropic Acid; Paxofen; Pedia-Profen; Pediaprofen; Pediatric Advil; Profen; Rafen; Rebugen; Roidenin; Rufen; Seclodin; Suspren; Tab-Profen; Tabalon; Trendar; Urem | ||
| Indication | For management of pain (muscular and rheumatic), sprains, strains, backache and neuralgia | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. | ||
| Mechanism Of Action | The exact mechanisms of action of Ibuprofen is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. | ||
| Ibuprofen News (When available) |
Teva shares plunge; Shire sues over Adderall patent infringement 06 Mar 2006 Treating ADD With Medication 06 Mar 2006 Sweeting suspended, charged with DUI, drug possession 06 Mar 2006 Shire sues Teva Pharmaceutical Industries Ltd. and Teva ... 06 Mar 2006 i tried adderall Mar 5, 2006 Shire sues Teva over generic Adderall Mar 3, 2006 Shire sues Teva over generic Adderall XR plans Mar 3, 2006 Shire sues Teva over generic Adderall XR plans Mar 3, 2006 Adderall Online: Black Market Profits In Plain Sight Mar 3, 2006 Shire blocks Teva's generic Adderall XR Mar 3, 2006 Evelyn Pringle: Adderall Online - Black Market Profits In Plain ... Feb 25, 2006 Shire Down; Adderall Headlines Cause Jitters Feb 8, 2006 FDA Advisory Committee Recommends ‘Black Box’ Warning for ... Feb 10, 2006 Shire Sues Teva Over ADHD Drug Mar 3, 2006 Shire sues Teva over generic Adderall XR plans Mar 3, 2006 A Safe Stimulant? Feb 27, 2006 Shire begins Teva legal proceedings Mar 3, 2006 Shire Plc: Strong 2005 Performance Supports Positive Outlook Feb 23, 2006 Do you think prescription drug abuse is a problem in public junior ... Mar 3, 2006 Laziness, pill-popping not true path to success Mar 3, 2006 Ph.D., Bonnie Slade: Parent worried about son's AD/HD medication Mar 3, 2006 Shire plc: Strong 2005 Performance Supports Positive Outlook Feb 23, 2006 FDA Forgot A Few ADHD Drug Related Deaths and Injuries Feb 19, 2006 Shire annual underlying earnings fall; Barr talks 'progressing' ... Feb 23, 2006 Illegal study drug boosts concentration Feb 11, 2006 Ex-ghostbuster seeks to become chart-buster Mar 5, 2006 Shire says settlement talks with Barr encouraging Feb 23, 2006 Shire hints at settlement with Barr over ADHD drug Feb 23, 2006 Shire's Search for Tranquility Feb 23, 2006 Shire Sues Teva Pharmaceutical Industries Ltd. and Teva ... Mar 3, 2006 Some students use ‘study drugs’ to cram Feb 22, 2006 Shire earnings fall, talks with Barr progressing Feb 23, 2006 Sacrificing health for good grades Feb 24, 2006 Evelyn Pringle: ADHD Drugs - Cash Cow For Pharma Feb 14, 2006 Shire annual underlying earnings fall Feb 23, 2006 Heart Risks With Stimulant Use? Maybe. Worry? For Some. Feb 20, 2006 drug firm appeals to watchdog Feb 23, 2006 ADD Drug Strattera, Already Under FDA Scrutiny, Raising New Safety ... Feb 21, 2006 Shire targets double digit growth Feb 23, 2006 Single-minded ADHD focus Feb 5, 2006 Attention-Deficit Drugs Need Watching, US FDA Says (Update1) Feb 8, 2006 Can you find concentration in a bottle Feb 18, 2006 Shire flips to loss in 2005, but says prospects good Feb 24, 2006 Shire: Shire 2006 Outlook Feb 24, 2006 25 died while using hyperactivity drugs Feb 9, 2006 Shire posted net loss of $410 million in fourth quarter Feb 23, 2006 Shire sues Teva for alleged patent infringement Mar 3, 2006 | ||
| Dosage Forms | Tablet; Suspension | ||
| Drug_Category | Analgesics; Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:C01EB16; ATC:G02CC01; ATC:M01AE01; ATC:M01AE14; ATC:M02AA13 | ||
| Absorption | rapidly absorbed | ||
| Interactions |
Interactions for Ibuprofen: Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that ibuprofen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants. Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on ibuprofen blood levels. Correlative clinical studies have not been performed. Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that ibuprofen could enhance the toxicity of methotrexate. Caution should be used if ibuprofen is administered concomitantly with methotrexate. H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations. Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with ibuprofen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy. Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration. This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy). | ||
| Toxicity | Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-[4-(2-methylpropyl)phenyl]propanoic acid | ||
| Chemical Formula | C13H18O2 | ||
| Molecular Weight | 206.281 g/mol | ||
| Smiles String | CC(C)CC1=CC=C(C=C1)C(C)C(=O)O | ||
| Melting Point | 75 - 77 °C | ||
| Water Solubility | 0.049 mg/ml | ||
| State | white powder | ||
| LogP/Hphobicity | 3.481 | ||
| Isoelectric Point | 4.91 | ||
| Biotransformation | Hepatic | ||
| Half Life | 1.8-2.0 hours | ||
| Protein Binding [%] | 99% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Ibuprofen.html http://www.rxlist.com/cgi/generic/ibup.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00372 | ||
| CAS Registry Number | 15687-27-1 | ||
| KEGG Compound ID | C01588 | ||
| PubChem ID | SID:170047 | ||
| PharmGKB ID | PA449957 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 636525 |
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