Ibuprofen drug data and news

Ibuprofen drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Ibuprofen
Brand Names/Synonyms Actiprofen; Adran; Advil; Advil Liqui-Gels; Amersol; Amibufen; Anco; Andran; Anflagen; Apo-Ibuprofen; Apsifen; Apsifen-F; Artril 300; Bluton; Brufanic; Brufen; Brufort; Buburone; Butylenin; Cap-Profen; Children's Advil; Children's Elixsure; Children's Ibuprofen; Children's Motrin; Codral; Dolgin; Dolgirid; Dolgit; Dolo-Dolgit; Dolocyl; Ebufac; Emodin; Epobron; Femadon; Fenbid Spansule; Haltran; IP-82; Ibu; Ibu-Attritin; Ibu-Slo; Ibu-Tab; Ibu-Tab 200; Ibufen; Ibumetin; Ibuprin; Ibuprocin; Ibuprofen; Ibuprohm; Ibutid; Ifen; Inabrin; Inoven; Junior Strength Advil; Junior Strength Ibuprofen; Junior Strength Motrin; Lamidon; Lebrufen; Lidifen; Liptan; Medipren; Midol; Midol 200; Motrin; Mynosedin; Napacetin; Nobfelon; Nobfen; Nobgen; Novogent N; Novoprofen; Nuprin; Nurofen; P-Isobutylhydratropic Acid; Pantrop; Para-Isobutylhydratropic Acid; Paxofen; Pedia-Profen; Pediaprofen; Pediatric Advil; Profen; Rafen; Rebugen; Roidenin; Rufen; Seclodin; Suspren; Tab-Profen; Tabalon; Trendar; Urem
Indication For management of pain (muscular and rheumatic), sprains, strains, backache and neuralgia
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Description Not Available
Pharmacology Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
Mechanism Of Action The exact mechanisms of action of Ibuprofen is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Ibuprofen News
(When available)

Teva shares plunge; Shire sues over Adderall patent infringement  06 Mar 2006
Britain’s Shire PLC Friday filed a lawsuit against Teva Pharmaceuticals Industries Limited (TEVA.NAS) for alleged patent infringement of its Adderall drug. ... - newratings.com

Treating ADD With Medication  06 Mar 2006
...medications are pemoline, known as Cylert; dextroamphetamine, known as Dexedrine and Dextrostat; and d- and l-amphetamin racemic mixture, known as Adderall. ... - DailyIndia.com,

Sweeting suspended, charged with DUI, drug possession  06 Mar 2006
Thursday morning. Sweeting, 18, was charged with a third-degree felony for possessing the drug Adderall without a prescription. He ... - CSTV.com,

Shire sues Teva Pharmaceutical Industries Ltd. and Teva ...  06 Mar 2006
...results from an Abbreviated New Drug Application filed by Teva for generic versions of 5 mg, 10 mg, 15 mg, 20 mg, 25 mg and 30 mg ADDERALL XR®, Shire's ... - Chemie.de (press release),

i tried adderall  Mar 5, 2006
...says. He says he started taking Adderall when a friend who has ADHD stopped taking his medication and wanted to get rid of it. The ... - Paly Voice,

Shire sues Teva over generic Adderall  Mar 3, 2006
BASINGSTOKE, England (UPI) -- Britain`s Shire PLC is suing Teva Pharmaceuticals for alleged patent infringement of its Adderall drug. ... - Monsters and Critics.com,

Shire sues Teva over generic Adderall XR plans  Mar 3, 2006
Teva Pharmaceuticals (TEVA.O: Quote, Profile, Research) over the Israeli drugmaker's plans to make a cheap, copycat version of hyperactivity drug Adderall XR. ... - Reuters

Shire sues Teva over generic Adderall XR plans  Mar 3, 2006
Shire Plc said on Friday it was suing Teva Pharmaceuticals over the Israeli drugmaker's plans to make a cheap, copycat version of hyperactivity drug Adderall XR ... - Scotsman,

Adderall Online: Black Market Profits In Plain Sight  Mar 3, 2006
...by Evelyn J. Pringle. Dubbed “Kiddie Coke,� Adderall is being abused by increasing numbers of high school and college students all across America. ... - Dissident Voice,

Shire blocks Teva's generic Adderall XR  Mar 3, 2006
BASINGSTOKE, England, March 3 (UPI) -- Shire said Friday it filed a lawsuit in US federal court claiming Teva infringed upon Shire's patents on Adderall XR. ... - United Press International

Evelyn Pringle: Adderall Online - Black Market Profits In Plain ...  Feb 25, 2006
Dubbed "Kiddie Coke," Adderall is being abused by increasing numbers of high school and college students all across America. It's ... - YubaNet (satire),

Shire Down; Adderall Headlines Cause Jitters  Feb 8, 2006
...dip to 861p. Traders blame the initial slide on reports on the company's drug Adderall ahead of an FDA meeting Thursday. "It's old ... - New Ratings

FDA Advisory Committee Recommends ‘Black Box’ Warning for ...  Feb 10, 2006
...death. The drugs include amphetamines, such as Adderall, and methylphenidates, sold as Ritalin, Concerta, Methylin, and Metadate. ... - Newsinferno.com,

Shire Sues Teva Over ADHD Drug  Mar 3, 2006
...lawsuit in the United States against Israel ’s Teva Pharmaceuticals over its intent to market a generic version of Shire’s hyperactivity drug, Adderall XR. ... - Red Herring,

Shire sues Teva over generic Adderall XR plans  Mar 3, 2006
...it was suing Teva Pharmaceuticals (Nasdaq:TEVA - news) over the Israeli drugmaker‘s plans to make a cheap, copycat version of hyperactivity drug Adderall XR. ... - Ely Times,

A Safe Stimulant?  Feb 27, 2006
There has been no shortage of attention on Adderall XR, Shire Plc.’s popular stimulant used to calm and focus millions of children and adults with attention ... - Forbes

Shire begins Teva legal proceedings  Mar 3, 2006
SHARECAST) - Drug giant Shire announced today that it has begun legal proceedings against Teva regarding generic copies of its hyperactivity drug Adderall. ... - ShareCast,

Shire Plc: Strong 2005 Performance Supports Positive Outlook  Feb 23, 2006
...and Europe. "Our lead product, ADDERALL XR, achieved an all time high market share of 26%. In ... Pharmaceuticals, Inc. - ADDERALL XR for ADHD. All ... - International News Service,

Do you think prescription drug abuse is a problem in public junior ...  Mar 3, 2006
..."Yeah. I think drugs like Adderall and Ritalin are overprescribed. I think it would help if the regulations on refills were more strict.". ... - Lawrence Journal World,

Laziness, pill-popping not true path to success  Mar 3, 2006
At the risk of sounding like a goody-two-shoes, it bothers me when students take Adderall to help them stay up all night to study and concentrate. ... - University of Pittsburgh The Pitt News,

Ph.D., Bonnie Slade: Parent worried about son's AD/HD medication  Mar 3, 2006
As you may know, there recently has been news about stimulant medications such as Ritalin, Concerta, Adderall, Methylin and Metadate. ... - Sebastian Sun (subscription),

Shire plc: Strong 2005 Performance Supports Positive Outlook  Feb 23, 2006
..."Our lead product, ADDERALL XR, achieved an all time high market share of 26%. ... Recent Developments in 2006 - ADDERALL XR for ADHD. ... - PR Newswire (press release),

FDA Forgot A Few ADHD Drug Related Deaths and Injuries  Feb 19, 2006
The Adderall-related death of an infant in Grand Forks, North Dakota was not listed in the report either. On January 30, 1999, Ron ... - Media Monitors Network,

Shire annual underlying earnings fall; Barr talks 'progressing' ...  Feb 23, 2006
And crucial talks with generics drugmaker Barr Laboratories concerning Adderall XR, the company's biggest product, are 'progressing', it said. ... - Forbes

Illegal study drug boosts concentration  Feb 11, 2006
Then she took another Adderall. At Grinnell and colleges across the country, many high achieving students have increasingly taken on a new label: drug user. ... - Grinnell College The Scarlet & Black,

Ex-ghostbuster seeks to become chart-buster  Mar 5, 2006
Percocet / Levitra, Levaquin, Elavil, Fosamax / Plavix, Keflex, Next day FedEx / Zithromax, Avelox, Flexeril, Topamax / Prozac, Ativan, Adderall / I take ’em ... - Columbus Dispatch,

Shire says settlement talks with Barr encouraging  Feb 23, 2006
Analysts are looking for Shire to settle a dispute with Barr which would delay the launch of a cheap, generic version of hyperactivity drug Adderall XR and ... - Scotsman,

Shire hints at settlement with Barr over ADHD drug  Feb 23, 2006
...yesterday there could soon be a settlement with Barr Pharmaceuticals which wants to make a copycat version of its top-selling hyperactivity drug, Adderall XR. ... - Independent,

Shire's Search for Tranquility  Feb 23, 2006
..."Any launch of a generic version of Adderall XR during ... Adderall XR is a once-a-day drug. Its older cousin Adderall contributed $43.1 million to overall sales. ... - TheStreet.com

Shire Sues Teva Pharmaceutical Industries Ltd. and Teva ...  Mar 3, 2006
The lawsuit results from an Abbreviated New Drug Application filed by Teva for generic versions of 5 mg, 10 mg, 15 mg, 20 mg, 25 mg and 30 mg ADDERALL XR(R ... - PR Newswire (press release),

Some students use ‘study drugs’ to cram  Feb 22, 2006
For many students, this situation is familiar, and to cope, some University of Wisconsin-Milwaukee students turn to stimulant “study drugs� such as Adderall ... - UWM Post,

Shire earnings fall, talks with Barr progressing  Feb 23, 2006
...excluding exceptional items, fell to $2.01 in 2005 as the cost of developing and launching new drugs offset strong sales of key hyperactivity drug Adderall XR. ... - Reuters

Sacrificing health for good grades  Feb 24, 2006
From Ritalin to Concerta to Adderall, students use and abuse methylphenidates even if they are not prescribed. Last semester, students ... - Daily Colonial,

Evelyn Pringle: ADHD Drugs - Cash Cow For Pharma  Feb 14, 2006
...that in February 2005, cardiovascular concerns raised in adverse event reports led Canadian health officials to suspend market authorization of Adderall XR for ... - Scoop.co.nz (press release),

Shire annual underlying earnings fall  Feb 23, 2006
Shire is trying to diversify its portfolio because its biggest product, Adderall XR, represents around half of sales and profits and will face cheaper generic ... - Forbes

Heart Risks With Stimulant Use? Maybe. Worry? For Some.  Feb 20, 2006
Doctors who treat adults and children with stimulants like Ritalin and Adderall say the risk is remote, given that an estimated 2.5 million children and 1.5 ... - New York Times,

drug firm appeals to watchdog  Feb 23, 2006
Shire makes the world's most widely used drug for attention deficit hyperactivity disorder (ADHD), Adderall, which already carries a black box warning because ... - Telegraph.co.uk,

ADD Drug Strattera, Already Under FDA Scrutiny, Raising New Safety ...  Feb 21, 2006
...the FDA announced it will be investigating all attention deficit hyperactivity disorder drugs including Strattera, Ritalin, Concerta, and Adderall in response ... - Newsinferno.com,

Shire targets double digit growth  Feb 23, 2006
...targeting low double digit growth for the current year and said it would ramp up investment in marketing as it looks to preserve bestseller Adderall’s market ... - ShareCast,

Single-minded ADHD focus  Feb 5, 2006
They are expected to look anew at warning labels, prompted by a heart-attack scare last summer from Shire's Adderall XR, the world's most-prescribed ADHD ... - Philadelphia Inquirer,

Attention-Deficit Drugs Need Watching, US FDA Says (Update1)  Feb 8, 2006
8 (Bloomberg) -- Shire Plc's Adderall and other stimulants used to treat attention-deficit disorder should be tracked for the risk of sudden death and heart ... - Bloomberg

Can you find concentration in a bottle  Feb 18, 2006
It is unknown exactly how many college students take stimulants, which may also include Adderall, a mix of four amphetamines, and atomoxetine, marketed as ... - Johns Hopkins News-Letter,

Shire flips to loss in 2005, but says prospects good  Feb 24, 2006
Sales rose to $1.6 billion, driven once again by the firm's mainstay treatment for attention deficit hyperactivity disorder, Adderall XR (mixed amphetamine ... - Pharma Times (subscription),

Shire: Shire 2006 Outlook  Feb 24, 2006
The following statements are based on the assumption that there will be no generic launch of ADDERALL XR during 2006 and prescription growth in the US ADHD ... - Webbolt Business News (subscription),

25 died while using hyperactivity drugs  Feb 9, 2006
Most of the deaths were associated with the drugs Adderall, Ritalin and Concerta. ... Canada later allowed Adderall sales to resume. ... - Newsday,

Shire posted net loss of $410 million in fourth quarter  Feb 23, 2006
2004 to 2005. Sales of its ADHD drugs Adderall and Adderall XR rose 21 percent, from $641 million to $774 million. The drugs now ... - philly.com,

Shire sues Teva for alleged patent infringement  Mar 3, 2006
A statement from Shire said the lawsuit results from an Abbreviated New Drug Application filed by Teva for generic versions of Adderall XR, Shire's Attention ... - Forbes

Dosage Forms Tablet; Suspension
Drug_Category Analgesics; Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:C01EB16; ATC:G02CC01; ATC:M01AE01; ATC:M01AE14; ATC:M02AA13
Absorption rapidly absorbed
Interactions Interactions for Ibuprofen:

Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that ibuprofen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants.

Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on ibuprofen blood levels. Correlative clinical studies have not been performed.

Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that ibuprofen could enhance the toxicity of methotrexate. Caution should be used if ibuprofen is administered concomitantly with methotrexate.

H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations.

Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with ibuprofen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.

This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).

Toxicity Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-[4-(2-methylpropyl)phenyl]propanoic acid
Chemical Formula C13H18O2
Molecular Weight 206.281 g/mol
Smiles String CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
Melting Point 75 - 77 °C
Water Solubility 0.049 mg/ml
State white powder
LogP/Hphobicity 3.481
Isoelectric Point 4.91
Biotransformation Hepatic
Half Life 1.8-2.0 hours
Protein Binding [%] 99%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Ibuprofen.html
http://www.rxlist.com/cgi/generic/ibup.htm
Drug Type Approved Drug
Accession No APRD00372
CAS Registry Number 15687-27-1
KEGG Compound ID C01588
PubChem ID SID:170047
PharmGKB ID PA449957
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 636525

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