Hyoscyamine drug data and news

Hyoscyamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Hyoscyamine

Brand Names/Synonyms

ATROPINE; Anaspaz; Cystospaz; Daturine; Duboisine; Duretter; Egacene; Egazil; Gastrosed; Hyocyamine; Hyoscyamine; Hyoscyamine, L-; L-Atropine; L-Hyopscyamine; L-Hyoscamine; L-Hyoscyamine; L-Hyoscyamine Free Base; L-Tropine Tropate; Levbid; Levsin; Levsinex; OIN; Peptard; Scopolia Extract

Indication

For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Hyoscyamine may also be used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis

Sponsored links

Description

Not Available

Pharmacology

L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent. Hyoscyamine is used to manage peptic ulcer disease, biliary tract disorders, cystitis, severe allergic rhinitis, hypermotility disorders of the lower urinary tract, infant colic, and to control salivation and excessive secretions before an operation.

Mechanism Of Action

Hyoscyamine competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contraction of the bladder detrusor muscle and of the gastrointestinal smooth muscle, and decreased gastrointestinal motility.

Hyoscyamine News
(When available)

From the analyst's couch: The IBS market Feb 15, 2006
...c and antidiarrhoeal agents such as loperamide for IBS-d. The pain associated with IBS can be addressed with antispasmodics such as dicyclomine and hyoscyamine ... - Nature.com (subscription),

Inkine Pharmaceutical Announces Approval of Merger with Salix ... Sep 30, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Business Wire (press release),

InKine Reports Seven INKP-102 Study Data Abstracts Accepted for ... Aug 4, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Forbes <**results**>

Italy: Lettuce uncovered as sexual stimulant Jun 29, 2005
...and lettuce, " he said. Typical tropane alkaloids are atropine, hyoscyamine, scopolamine and cocaine. According to Samorini, tropane ... - FreshPlaza

InKine Announces Final Court Approval in Securities Class Action ... Jun 16, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Genetic Engineering News,

Inkine's Visicol Tablets Associated with Significantly Less After ... May 19, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Business Wire,

InKine CEO To Present at the Rodman & Renshaw Techvest 2nd Annual ... 29 Apr 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Business Wire,

Inappropriate medication prescribed to elderly Mar 8, 2005
The medications cited as ''Always avoid'' are: barbiturates, belladonna alkaloids, chlorpropamide, dicyclomine, flurazepam, hyoscyamine, meperidine, meprobamate ... - Helena Independent Record,

Almost One In Three Seniors Given Inappropriate Meds Feb 26, 2005
Specifically, the study showed that at least 1 percent of the seniors received the antispasmodic drugs belladonna alkaloids, hyoscyamine and dicyclomine, all ... - RedNova.com,

InKine to Present at BIO CEO & Investor Conference Feb 17, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - PharmaLive.com (press release),

Almost One In Three Seniors Given Inappropriate Meds Feb 25, 2005
Specifically, the study showed that at least 1 percent of the seniors received the antispasmodic drugs belladonna alkaloids, Hyoscyamine and Dicyclomine, all ... - drkoop.com

With Positive INKP-102 Results, InKine Prepares For NDA Filing Feb 22, 2005
Along with Visicol, InKine has another marketed product, IB-STAT, an oral spray formulation of hyoscyamine sulfate for irritable bowel syndrome in adult women ... - BioWorld Online (subscription)

Dosage Forms

Oral tablets, oral drops, elixir, injection

Drug_Category

Mydriatics; Bronchodilator Agents; Antiarrhythmic Agents; Adjuvants; Antimuscarinics; Antispasmodics; ATC:A03BA03

Absorption

absorbed totally and completely by sublingual administration as well as oral administration

Interactions

Interactions for Hyoscyamine:

Additive adverse effects resulting from cholinergic blockade may occur when LEVSIN is administered concomitantly with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants or some antihistamines. Antacids may interfere with the absorption of LEVSIN. Administer LEVSIN before meals; antacids after meals.

Toxicity

headache nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation. LD50=mg/kg(orally in rat)

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)3-hydroxy-2-phenyl-propanoate

Chemical Formula

C17H23NO3

Molecular Weight

289.369 g/mol

Smiles String

CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3

Melting Point

141°C

Water Solubility

1g/281mL

State

Solid

LogP/Hphobicity

2.904

Isoelectric Point

11.7

Biotransformation

Hepatic

Half Life

2-3 1/2 hours

Protein Binding [%]

50%

RxList Link

RXlist

Sponsored links

Drug Reference

http://www.drugs.com/cons/Hyoscyamine.html
http://www.rxlist.com/cgi/generic/hyoscy.htm

Drug Type

Approved Drug

Accession No

APRD00607

CAS Registry Number

101-31-5

KEGG Compound ID

Not Available

PubChem ID

SID:206628

PharmGKB ID

Not Available

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

125857