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Hydroxyzine
drug data and news
Hydroxyzine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Hydroxyzine | ||
| Brand Names/Synonyms | Alamon; Atara; Atarax; Atarax Base; Ataraxoid; Atarazoid; Atarox; Atazina; Aterax; CHEMBANK2612; Deinait; Durrax; Equipoise; Equipose; Fenarol; HSDB 3098; Hidroxizina [Inn-Spanish]; Hy-Pam 25; Hychotine; Hydroksyzyny; Hydroksyzyny [Polish]; Hydroxine; Hydroxizine; Hydroxizinum; Hydroxycine; Hydroxyzin; Hydroxyzine; Hydroxyzine Base; Hydroxyzine Hcl; Hydroxyzine Pamoate; Hydroxyzinum [Inn-Latin]; Hydroxyzyne; Idrossizina; Idrossizina [Dcit]; Masmoran; NP 212; Neo-Calma; Neurozina; Nevrolaks; Orgatrax; Pamazone; Parenteral; Paxistil; Placidol; Plaxidol; Quiess; Tran-Q; Tranquizine; Traquizine; U.C.B 4492; U.CB 4492; UCB 4492; UCB 492; UCB-4492; Vesparaz-Wirkstoff; Vistaril; Vistaril Pamoate; Vistazine | ||
| Indication | For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist. | ||
| Mechanism Of Action | Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic. | ||
| Hydroxyzine News (When available) |
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| Dosage Forms | CAPSULE; LIQUID; SOLUTION; SYRUP | ||
| Drug_Category | Antipruritics; Histamine H1 Antagonists; Anxiolytics sedatives and hypnotics; ATC:N05BB01 | ||
| Absorption | Rapidly absorbed from the gastrointestinal tract | ||
| Interactions |
Interactions for Hydroxyzine: THE POTENTIATING ACTION OF HYDROXYZINE MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES. Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced. Since drowsiness may occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking Atarax. Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased. | ||
| Toxicity | Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol | ||
| Chemical Formula | C21H27ClN2O2 | ||
| Molecular Weight | 374.904 g/mol | ||
| Smiles String | C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl | ||
| Melting Point | 190 °C | ||
| Water Solubility | < 700 mg/mL | ||
| State | Solid (white, odorless powder) | ||
| LogP/Hphobicity | 3.036 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 20 to 25 hours | ||
| Protein Binding [%] | 93% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Hydroxyzine.html http://www.rxlist.com/cgi/generic/hydrox.htm http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ata1035.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00688 | ||
| CAS Registry Number | 68-88-2 | ||
| KEGG Compound ID | C07045 | ||
| PubChem ID | SID:43241 | ||
| PharmGKB ID | PA449943 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 739618 |
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