Hydroxyzine drug data and news

Hydroxyzine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Hydroxyzine
Brand Names/Synonyms Alamon; Atara; Atarax; Atarax Base; Ataraxoid; Atarazoid; Atarox; Atazina; Aterax; CHEMBANK2612; Deinait; Durrax; Equipoise; Equipose; Fenarol; HSDB 3098; Hidroxizina [Inn-Spanish]; Hy-Pam 25; Hychotine; Hydroksyzyny; Hydroksyzyny [Polish]; Hydroxine; Hydroxizine; Hydroxizinum; Hydroxycine; Hydroxyzin; Hydroxyzine; Hydroxyzine Base; Hydroxyzine Hcl; Hydroxyzine Pamoate; Hydroxyzinum [Inn-Latin]; Hydroxyzyne; Idrossizina; Idrossizina [Dcit]; Masmoran; NP 212; Neo-Calma; Neurozina; Nevrolaks; Orgatrax; Pamazone; Parenteral; Paxistil; Placidol; Plaxidol; Quiess; Tran-Q; Tranquizine; Traquizine; U.C.B 4492; U.CB 4492; UCB 4492; UCB 492; UCB-4492; Vesparaz-Wirkstoff; Vistaril; Vistaril Pamoate; Vistazine
Indication For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
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Description Not Available
Pharmacology Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Mechanism Of Action Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
Hydroxyzine News
(When available)

Skin Problems in Horses  Feb 1, 2006
..."I also use an antihistamine type of drug, hydroxyzine," he says. "Typical antihistamines are usually ineffective in horses, but ... - TheHorse.com,

Skin Problems in Horses  Feb 1, 2006
..."I also use an antihistamine type of drug, hydroxyzine," he says. "Typical antihistamines are usually ineffective in horses, but ... - TheHorse.com,

Woman's trial in son's deathset to start  Jan 29, 2006
...he died. They found her bottle of hydroxyzine, an anti-anxiety medicine, in the pocket of her older boy the day he died. Police ... - Orlando Sentinel,

Worrying all the time?  Aug 31, 2005
These include benzodiazepines, buspirone, hydroxyzine, and antidepressants. ... Hydroxyzine is a medication that has long been available. ... - Health24.com,

Acute Akathisia Associated With Quetiapine Use  Jul 6, 2005
...normal limits. On admission, the patient began a 5-day tapering-dose regimen of methadone, hydroxyzine, and acetaminophen. Ms. A ... - Psychosomatics (subscription) <**results**>

Acute Akathisia Associated With Quetiapine Use  Jul 6, 2005
...normal limits. On admission, the patient began a 5-day tapering-dose regimen of methadone, hydroxyzine, and acetaminophen. Ms. A ... - Psychosomatics (subscription)

TeenScreen sets up shop In Illinois  Jun 20, 2005
...by Medicaid in July 2004. Hydroxyzine was prescribed most often, with about three-quarters of the kids on it. The drug, a long-acting ... - Online Journal

Common skin conditions and treatments  Jun 16, 2005
Medications include antihistamines such as hydroxyzine and doxepin, antibiotics for any bacterial infection, oral steroids such as prednisone, and creams ... - Louisville Courier-Journal,

TeenScreen sets up shop In Illinois  Jun 20, 2005
...by Medicaid in July 2004. Hydroxyzine was prescribed most often, with about three-quarters of the kids on it. The drug, a long-acting ... - Online Journal,

Common skin conditions and treatments  Jun 16, 2005
Medications include antihistamines such as hydroxyzine and doxepin, antibiotics for any bacterial infection, oral steroids such as prednisone, and creams ... - Louisville Courier-Journal,

Computer program  Apr 12, 2005
...to the confusion. There's also Hydroxyzine, an antihistamine, and Hydralazine (for high blood pressure.). Whittington also suggests ... - Peoria Journal Star

Police And Fire  Mar 29, 2005
They searched her purse and car and found suspected meth, suspected cocaine, hydroxyzine pills, glass pipes and rolling paper, the report states. ... - Fort Smith Times Record

Police beat  Apr 4, 2005
A search of the apartment produced 11 Hydroxyzine pills, a cut straw that tested positive for cocaine and a usable amount of marijuana. ... - Maine Campus Online (subscription)

Pets' allergies can be tough to treat  Apr 4, 2005
...effects. So they are definitely worth a try. The most commonly used are Benadryl, chlorpheneramine and hydroxyzine. Other treatments ... - Vail Daily News,

FDA Safety Labeling Changes: Vistaril, Estraderm, Nolvadex  Mar 2, 2005
FDA) approved in December 2004 revisions to safety labeling to advise healthcare professionals of the following changes: use of hydroxyzine pamoate capsules ... - Medscape (subscription)

Itching, Remedies Itching Causes, Skin Problems  Feb 23, 2005
There are treatments available to reduce itching. Antihistamine medications such as hydroxyzine and diphenhydramine can be helpful. ... - Express Newsline,

Dosage Forms CAPSULE; LIQUID; SOLUTION; SYRUP
Drug_Category Antipruritics; Histamine H1 Antagonists; Anxiolytics sedatives and hypnotics; ATC:N05BB01
Absorption Rapidly absorbed from the gastrointestinal tract
Interactions Interactions for Hydroxyzine:

THE POTENTIATING ACTION OF HYDROXYZINE MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES. Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced.

Since drowsiness may occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking Atarax. Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased.

Toxicity Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol
Chemical Formula C21H27ClN2O2
Molecular Weight 374.904 g/mol
Smiles String C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
Melting Point 190 °C
Water Solubility < 700 mg/mL
State Solid (white, odorless powder)
LogP/Hphobicity 3.036
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 20 to 25 hours
Protein Binding [%] 93%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Hydroxyzine.html
http://www.rxlist.com/cgi/generic/hydrox.htm
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ata1035.shtml
Drug Type Approved Drug
Accession No APRD00688
CAS Registry Number 68-88-2
KEGG Compound ID C07045
PubChem ID SID:43241
PharmGKB ID PA449943
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 739618

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