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Hexachlorophene
drug data and news
Hexachlorophene drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Hexachlorophene | ||
| Brand Names/Synonyms | AT-17; AT-7; Acigena; Almederm; B 32; Bilevon; Bivelon; Compound G-11; Cotofilm; Dermadex; Dial; Distodin; E-Z Scrub; Eleven; Exofene; Fascol; Fesia-Sin; Fomac; Fostril; G-11; G-Eleven; G-II; Gamophen; Gamophene; Germa-Medica; HCP; Hexa-Germ; Hexabalm; Hexachlorofen; Hexachlorophane; Hexachlorophen; Hexachlorophene; Hexachlorophene, Pharma; Hexafen; Hexascrub; Hexazinone; Hexide; Hexophene; Hexosan; Isobac; Isobac 20; NCI-C02653; Nabac; Nabac 25 Ec; Neosept V; Phiso-Scrub; Phisodan; Phisohex; Pre-Op; Rcra Waste Number U132; Ritosept; Scrubteam Surgical Spongebrush; Septi-Soft; Septisol; Septofen; Soy-Dome; Ster-Zac; Steral; Steraskin; Surgi-Cen; Surgi-Cin; Surofene; Tersaseptic; Trichlorophene; Turgex; UN 2875 | ||
| Indication | For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue. | ||
| Mechanism Of Action | The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration. | ||
| Hexachlorophene News (When available) |
Best Practices for 2006 Feb 1, 2006 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Anti-Infectives; ATC:D08AE01 | ||
| Absorption | Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene. | ||
| Interactions |
Interactions for Hexachlorophene: No information available. | ||
| Toxicity | Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities. | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol | ||
| Chemical Formula | C13H6Cl6O2 | ||
| Molecular Weight | 406.902 g/mol | ||
| Smiles String | C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl | ||
| Melting Point | 166.5 oC (boiling point) | ||
| Water Solubility | 140 mg/L | ||
| State | Liquid | ||
| LogP/Hphobicity | 6.941 | ||
| Isoelectric Point | 4.95 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 92% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.rxlist.com/cgi/generic2/hexchlorph.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00722 | ||
| CAS Registry Number | 70-30-4 | ||
| KEGG Compound ID | C08039 | ||
| PubChem ID | SID:149191 | ||
| PharmGKB ID | PA449871 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2017733 |
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