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Hesperetin
drug data and news
Hesperetin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Hesperetin
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| Brand Names/Synonyms |
Cyanidanon 4'-Methyl Ether 1626; Hesperetin; Hesperin; Hesperitin; YSO2 |
| Indication |
For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again |
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Description |
Not Available |
| Pharmacology |
Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80% |
| Mechanism Of Action |
Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels. |
Hesperetin News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Anticholesteremic Agents |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-chroman-4-one |
| Chemical Formula |
C16H14O6 |
| Molecular Weight |
302.279 g/mol |
| Smiles String |
COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O |
| Melting Point |
227.5 °C |
| Water Solubility |
273 mg/L |
| State |
Solid |
| LogP/Hphobicity |
2.174 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00117 |
| CAS Registry Number |
520-33-2 |
| KEGG Compound ID |
C01709 |
| PubChem ID |
SID:64745 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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