Halothane drug data and news

Halothane drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Halothane
Brand Names/Synonyms Alotano; Alotano [Dcit]; Anestan; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; CCRIS 6244; Cf3chclbr; Chalothane; Fluktan; Fluorotane; Fluorothane; Fluothane; Freon 123b1; Ftorotan; Ftorotan [Russian]; Ftuorotan; HSDB 6753; Halan; Halotan; Halotano; Halotano [Inn-Spanish]; Halothan; Halothane; Halothane [Anaesthetics, Volatile]; Halothane [Ban:Inn:Jan]; Halothanum [Inn-Latin]; Halsan; Narcotan; Narcotane; Narcotann Ne-Spofa; Narcotann Ne-Spofa [Russian]; Narkotan; Phthorothanum; Rhodialothan
Indication For the induction and maintenance of general anesthesia
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Description Not Available
Pharmacology Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Mechanism Of Action Halothane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Halothane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Halothane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Halothane News
(When available)

Army Officer Takes MDF to Task Over Presidential Pilot  07 Mar 2006
Hospital in Blantyre shows that Mwale paid K243,365.65 medical care, accommodation, major theatre, oxygen and nitrous oxide, halothane/ Fluothane, guardians ... - AllAfrica.com,

Upper Airway Collapsibility in Anesthetized Children  Feb 21, 2006
A secondary aim was to compare differences in upper airway collapsibility after the administration of sevoflurane or halothane. ... - Anesthesia & Analgesia (subscription),

The Ventilatory Stimulant Doxapram Inhibits TASK Tandem Pore (K 2P ...  Feb 21, 2006
...brainstem. Acidic pH values and hypoxia inhibit TASK-1 and TASK-3 channel function, and halothane enhances this function. These ... - Anesthesia & Analgesia (subscription),

The Tongue Flap: An Iatrogenic Difficult Airway?  Feb 21, 2006
...airway. Anesthesia was induced with IV ketamine 75 mg followed by ventilation with oxygen and nitrous oxide 50:50 and 1% halothane. ... - Anesthesia & Analgesia (subscription),

Pharmacokinetics and Pharmacodynamics of a 0.1 mg/kg Dose of ...  Feb 21, 2006
Pharmacodynamic results were comparable to those obtained in pediatric studies during halothane or opioid anesthesia with the exception of a longer recovery to ... - Anesthesia & Analgesia (subscription),

Going Under  Feb 6, 2006
...he adds. Drugs used for inhalation anesthesia in horses include halothane, isoflurane, and sevoflurane, says Hubbell. For intravenous ... - TheHorse.com,

Routine Inhaled Induction in Adults: A Safe Practice?  Feb 14, 2006
...nasal). The authors refer to anesthesiologists’ concerns over the risks of halothane and the relative safety of sevoflurane. Though ... - Anesthesia & Analgesia (subscription),

Dosage Forms SOLUTION
Drug_Category Anesthetics; Anesthetics, Inhalation; General Anesthetics; ATC:N01AB01
Absorption Not Available
Interactions Interactions for Halothane:

FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides.

FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine.

Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated. For this reason the dose of adrenaline should be restricted and an antiarrhythmic agent administered as appropriate. Caution should also be applied for other sympathomimetics, and for aminophylline and theophylline and tricyclic antidepressants, which may also precipitate arrhythmias.

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-bromo-2-chloro-1,1,1-trifluoro-ethane
Chemical Formula C2HBrClF3
Molecular Weight 197.381 g/mol
Smiles String C(C(F)(F)F)(Cl)Br
Melting Point -118 °C
Water Solubility 3.45 mg/ml
State Liquid
LogP/Hphobicity 2.549
Isoelectric Point Not Available
Biotransformation Not Available
Half Life Not Available
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Halothane.html
http://www.rxlist.com/cgi/generic2/halothane.htm
Drug Type Approved Drug
Accession No APRD00598
CAS Registry Number 151-67-7
KEGG Compound ID C07515
PubChem ID SID:64715
PharmGKB ID PA449845
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 589187

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