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Haloperidol
drug data and news
Haloperidol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Haloperidol | ||
| Brand Names/Synonyms | ALDO; Aloperidin; Aloperidol; Aloperidolo; Aloperidon; Apo-Haloperidol; Bioperidolo; Brotopon; Dozic; Dozix; Einalon S; Eukystol; Galoperidol; Haldol; Haldol Decanoate; Haldol La; Haldol Solutab; Halidol; Halojust; Halol; Halopal; Haloperido; Haloperidol; Haloperidol Decanoate; Haloperidol Intensol; Haloperidol Lactate; Halopidol; Halopoidol; Halosten; Keselan; Lealgin Compositum; Linton; Mixidol; Novo-Peridol; Pekuces; Peluces; Peridol; Pernox; Pms Haloperidol; R 1625; R-1625; Serenace; Serenase; Serenelfi; Sernas; Sernel; Sigaperidol; Ulcolind; Uliolind; Vesalium | ||
| Indication | For the treatment of schizophrenic patients who require prolonged parenteral antipsychotic therapy also used in Tourette's syndrome and Severe hyperactivity | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Haloperidol is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Haloperidol has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Haloperidol has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity. | ||
| Mechanism Of Action | The precise mechanism whereby the therapeutic effects of Haloperidol are produced is not known. Its effect on the central nervous system is thought to be associated with the competitive blockade of postsynaptic dopamine D2 receptors in the mesolimbic dopaminergic system and an increased turnover rate of brain dopamine. | ||
| Haloperidol News (When available) |
Medical panel reprimands state doctors 07 Mar 2006 Prosecutors Say No Deal; Police Say Hydrocodone Not In System Feb 17, 2006 Howell’s death an accident, jury says Mar 2, 2006 Nearly 100 people charged in Operation Rx Feb 28, 2006 KC man arrested in Harrisonville for possession Mar 3, 2006 Grand Jury hands down indictments Mar 5, 2006 Pills send middle schooler to hospital Feb 26, 2006 Attorney: Investor’s overdose accidental Feb 28, 2006 Police say teacher altered prescription Feb 28, 2006 St. Landry drug arrest Mar 3, 2006 Lincoln grand jury indicts man on burglary charges Mar 3, 2006 AT THE COURTHOUSE Mar 2, 2006 School discovers drugs on student Mar 3, 2006 Former pharmacist sentenced for fraudulent prescriptions Mar 4, 2006 A Day At The Doctor's Office Feb 20, 2006 Pharmacist Indicted Feb 22, 2006 Giving drugs to minors yields charges Feb 15, 2006 67-year-old viewed as major dealer Mar 1, 2006 Indictments handed down in Brown County Feb 27, 2006 Prosecutors drop murder charge in death of junior college student Feb 19, 2006 More than $36,500 in drugs seized Mar 2, 2006 24 arrested in drug ring bust Mar 1, 2006 Internet found to help drugs trafficking Mar 2, 2006 Man held in imprisonment case Feb 28, 2006 Prosecutors drop murder charge in death of junior college student Feb 19, 2006 Woman to face theft, drug charges Mar 1, 2006 News in brief from western Pennsylvania Feb 27, 2006 News in brief from western Pennsylvania Feb 27, 2006 Knox County woman charged with TennCare fraud Mar 2, 2006 Feds to take pain clinic case: US district attorney to handle ... Feb 23, 2006 Nurses Arrested In Prescription Drug Sweep Feb 19, 2006 ON THE RECORD: W.Va. State Police felony arrest Feb 28, 2006 Parsons sentenced for violating probation Feb 27, 2006 Longville woman arrested on way to sell methamphetamines Feb 25, 2006 Judge’s Son Subject Of Professional Misconduct Probe Feb 25, 2006 ASK THE DOCTOR: Side effects from codeine just that, not allergic ... Feb 28, 2006 Alleged drug dealer denied bond reduction Mar 1, 2006 Norman woman charged in carjacking Feb 27, 2006 Druggist charged with forgery Feb 25, 2006 Crocker pleads guilty to selling drugs Feb 19, 2006 92 charged in drug sting Feb 28, 2006 New River Provides Clinical Test Results on NRP290 and Receives ... Feb 7, 2006 My procreating days are over. Yes! Feb 14, 2006 State police round up more than 25 suspected drug dealers in ... Feb 9, 2006 2 arrested for possession of heroin Feb 17, 2006 | ||
| Dosage Forms | INJECTION; ORAL SOLUTION; TABLET | ||
| Drug_Category | Antidyskinetics; Antipsychotics; Antiemetics; Butyrophenones; Dopamine Antagonists; ATC:N05AD01 | ||
| Absorption | Oral-60% | ||
| Interactions |
-->Interactions for Haloperidol: An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN, and FBS) followed by irreversible brain damage has occurred in a few patients treated with lithium plus HALDOL. A causal relationship between these events and the concomitant administration of lithium and HALDOL has not been established; however, patients receiving such combined therapy should be monitored closely for early evidence of neurological toxicity and treatment discontinued promptly if such signs appear. As with other antipsychotic agents, it should be noted that HALDOL may be capable of potentiating CNS depressants such as anesthetics, opiates, and alcohol. In a study of 12 schizophrenic patients coadministered oral haloperidol and rifampin, plasma haloperidol levels were decreased by a mean of 70% and mean scores on the Brief Psychiatric Rating Scale were increased from baseline. In 5 other schizophrenic patients treated with oral haloperidol and rifampin, discontinuation of rifampin produced a mean 3.3-fold increase in haloperidol concentrations. Thus, careful monitoring of clinical status is warranted when rifampin is administered or discontinued in haloperidol-treated patients. | ||
| Toxicity | LD50=165 mg/kg (rats, oral) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one | ||
| Chemical Formula | C21H23ClFNO2 | ||
| Molecular Weight | 375.864 g/mol | ||
| Smiles String | C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F | ||
| Melting Point | 151.5 °C | ||
| Water Solubility | 14 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 4.362 | ||
| Isoelectric Point | 8.66 | ||
| Biotransformation | Hepatic | ||
| Half Life | 3 weeks | ||
| Protein Binding [%] | 92% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Haloperidol.html http://www.rxlist.com/cgi/generic/haloper.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00538 | ||
| CAS Registry Number | 52-86-8 | ||
| KEGG Compound ID | C01814 | ||
| PubChem ID | SID:148665 | ||
| PharmGKB ID | PA449841 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 761745 |
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