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Halofantrine
drug data and news
Halofantrine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Halofantrine | ||
| Brand Names/Synonyms | Halfan; Halofantrina; Halofantrina [Inn-Spanish]; Halofantrine; Halofantrine [Usan]; Halofantrinum; Halofantrinum [Inn-Latin] | ||
| Indication | For treatment of Severe malaria | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Halofantrine is a synthetic antimalarial which acts as a blood schizonticide. It is effective against multi drug resistant (including mefloquine resistant) P. falciparum malaria. | ||
| Mechanism Of Action | The mechanism of action of Halofantrine may be similar to that of chloroquine, quinine, and mefloquine; by forming toxic complexes with ferritoporphyrin IX that damage the membrane of the parasite. | ||
| Halofantrine News (When available) |
Hindustan Times, ...colleagues indicate that previously unknown mutations in the pfrct gene are associated with Plasmodium falciparum's resistance to halofantrine and amantadine. ... | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Antimalarials; ATC:P01BX01 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Side effects incldue coughing noisy, rattling, troubled breathing, loss of appetite, aches and pain in joints, indigestion,and skin itching or rash. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-dibutylamino-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-propan-1-ol | ||
| Chemical Formula | C26H30Cl2F3NO | ||
| Molecular Weight | 500.423 g/mol | ||
| Smiles String | CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 9.199 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 6-10 days | ||
| Protein Binding [%] | 60-70%; | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Halofantrine.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00419 | ||
| CAS Registry Number | 69756-53-2 | ||
| KEGG Compound ID | C07634 | ||
| PubChem ID | SID:603092 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2162857 |
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