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Guanabenz
drug data and news
Guanabenz drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Guanabenz | ||
| Brand Names/Synonyms | GBZ; Guanabenz; Guanabenz Acetate; Guanabenz [USAN:INN]; Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; HSDB 6535; Wy 8678; Wy 8678 base; Wy-8678; Wytensin; EINECS 225-750-8; Guanabenz(USAN) | ||
| Indication | For management of High blood pressure | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Guanabenz, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension. | ||
| Mechanism Of Action | Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance. | ||
| Guanabenz News (When available) |
O'Connor stripped of medal Jul 3, 2005 doping saga will run to a sequel Mar 24, 2005 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Sympatholytics; Antihypertensive Agents; | ||
| Absorption | Approximately 75% absorbed from gastrointestinal tract | ||
| Interactions | Not Available | ||
| Toxicity | Excessive contraction of the pupils, irritabilitylow blood pressure, sleepiness, slow heartbeat, sluggishness | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | (2,6-dichlorophenyl)methylideneaminoiminomethanediamine | ||
| Chemical Formula | C8H8Cl2N4 | ||
| Molecular Weight | 231.081 g/mol | ||
| Smiles String | C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl | ||
| Melting Point | 228 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 2.575 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 6 hours. | ||
| Protein Binding [%] | 90% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Guanabenz.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/gua1612.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00487 | ||
| CAS Registry Number | 5051-62-7 | ||
| KEGG Compound ID | C07034 | ||
| PubChem ID | SID:9246 | ||
| PharmGKB ID | PA449819 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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