Glyburide drug data and news

Glyburide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Glyburide
Brand Names/Synonyms Abbenclamide; Adiab; Apo-Glibenclamide; Azuglucon; Bastiverit; Benclamin; Betanase; Betanese 5; CHEMBANK74; Calabren; Cytagon; Daonil; Debtan; Dia-Basan; Diabeta; Diabiphage; Dibelet; Duraglucon; Euclamin; Euglucan; Euglucon; Euglucon 5; Euglykon; G106; G2539; GBN 5; Gen-Glybe; Gewaglucon; Gilemal; Glamide; Glibadone; Gliban; Gliben; Glibenbeta; Glibenclamid Al; Glibenclamid Basics; Glibenclamid Fabra; Glibenclamid Genericon; Glibenclamid Heumann; Glibenclamid Riker M.; Glibenclamid-Cophar; Glibenclamid-Ratiopharm; Glibenclamida [Inn-Spanish]; Glibenclamide; Glibenclamidum [Inn-Latin]; Glibenil; Glibens; Glibesyn; Glibet; Glibetic; Glibil; Gliboral; Glicem; Glidiabet; Glimel; Glimide; Glimidstata; Glisulin; Glitisol; Glubate; Gluben; Gluco-Tablimen; Glucobene; Glucohexal; Glucolon; Glucomid; Glucoremed; Glucoven; Glyben; Glybenclamide; Glybenzcyclamide; Glyburide; Glyburide [Usan]; Glycolande; Glycomin; Glynase; HB 419; HD 419; Hemi-Daonil; Hexaglucon; Humedia; KC-120; Lederglib; Libanil; Lisaglucon; Malix; Maninil; Med-Glionil; Melix; Micronase; Miglucan; Nadib; Neogluconin; Norglicem 5; Normoglucon; Novo-Glyburide; Orabetic; Pira; Praeciglucon; Prestab; Prodiabet; Renabetic; Semi-Daonil; Semi-Euglucon; Sugril; Suraben; Tiabet; UR 606; Yuglucon
Indication For treatment and management of Type II diabetes mellitus
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Description Not Available
Pharmacology Glyburide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Glyburide is twice as potent as the related second-generation agent glipizide.
Mechanism Of Action Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Glyburide News
(When available)

Why Aren't Drugs Tested on Pregnant Women?  Feb 24, 2006
He chose to study glyburide, a drug commonly used by pregnant women who develop diabetes. "There is a lot we don't know," he said. ... - ABC News

Diabetes Is Seen as a Rising Risk in Mothers-to-Be  Feb 18, 2006
...their blood sugar four times a day. Some doctors substitute an oral drug, glyburide, for insulin. Jane Martinez Dowling, 37, a part ... - Spartanburg Herald Journal (subscription),

Study Finds More Fractures, Less Bone Density In Premenopausal ...  Jan 28, 2006
...medication metformin were randomly assigned to additional treatment with either rosiglitazone (which improves insulin sensitivity) or glyburide (which promotes ... - DG News

Mortality Rises as Sulfonylurea Dose Increases  Jan 20, 2006
The antidiabetic agents used included first-generation sulfonylureas for 120 subjects, glyburide for 4138, and metformin for 1537. ... - Medscape (subscription)

Smarter lifestyles can reduce the risk of getting diabetes  Jan 12, 2006
...at all.". Reyes also watches her weight and uses the drugs glyburide and metformin to keep her blood sugar levels in order. Like ... - Toronto Star,

Sulfonylureas for Type 2 Diabetes Drugs Linked to Heart Deaths  Jan 17, 2006
A second group included 4,138 who received Diabeta (glyburide), and the third group included 1,537 who received the non-sulfonylurea drug metforminmetformin ... - CNN

Risks of sulfonylurea drugs in the treatment of diabetes mellitus  Jan 16, 2006
Patients who were prescribed a sulfonylurea drug (chlorpropamide, tolbutamide or glyburide) experienced higher mortality rates than those who received metformin ... - EurekAlert (press release),

Potential health risk associated with Chinese medicine Shortclean  Nov 21, 2005
Health Canada is warning consumers not to take the Chinese medicine Shortclean because it contains Glibenclamide ( Glyburide ) and Phenformin, two prescription ... - Xagena.it,

Health Canada Warning Consumers Not To Take Chinese Medicine ' ...  Nov 17, 2005
OTTAWA - Canada is warning consumers not to take the Chinese medicine Shortclean because it contains glibenclamide (glyburide) and phenformin, two prescription ... - Halifax Live,

Hypoglycemia associated with the use of gatifloxacin.  Nov 15, 2005
...outlined. Case 1: A 89-year-old diabetic male receiving glyburide was given a single dose of gatifloxacin for bronchitis. Thirteen ... - HeartZine,

The Effect Of Tracleer™ On Male Fertility with Primary Pulmonary ...  Nov 19, 2005
...the formulation. Treatment with glyburide, cyclosporine A or tacrolimus at inclusion or planned during the study. Treatment with ... - Community Dispatch (press release)

Endocrinology & Metabolism News, September 2005  Oct 3, 2005
After administration of a single glyburide or glipizide dose to eight nursing women, drug was not detected in breast milk, and hypoglycemia was not observed in ... - Journal of Clinical Endocrinology and Metabolism,

Many meds don't mix with the sun  Sep 21, 2005
Antidiabetic agents: Acetohexamide (Dymelor), chlorpro-pamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase ... - Pioneer Press,

Bristol/Merck Pargluva Combination Use With Sulfonylurea Not ...  Sep 9, 2005
While a trial comparing muraglitazar plus metformin to pioglitazone plus metformin accounted for a majority of deaths, a muraglitazar plus glyburide vs. ... - FDA Advisory Committee

Supplement of the Month - Cinnamon  Sep 6, 2005
...may cause blood glucose to be excessively lowered when combined with agents that can cause hypoglycemia, such as sulfonylureas (Amaryl, glyburide or glipizide ... - Diabetes Interview,

Endocrinology & Metabolism News, September 2005  Sep 7, 2005
After administration of a single glyburide or glipizide dose to eight nursing women, drug was not detected in breast milk, and hypoglycemia was not observed in ... - Journal of Clinical Endocrinology and Metabolism,

Contributions of Basal and Post-Prandial Hyperglycaemia to Micro ...  Aug 12, 2005
Figure 2. Glycated haemoglobin (HbA^sub 1c^ levels at the end of a 3-month study in 135 people with diabetes randomized to glyburide plus either insulin lispro ... - RedNova.com,

FDA Sends Warning Letter to Actelion Over Tracleer Web Page  Jul 26, 2005
Glyburide: An increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with bosentan. ... - PharmaLive.com (press release)

Warning issued by FDA over "Liqiang 4 Capsules"  Jul 10, 2005
The FDA has recently issued a warning regarding the consumption of Liqiang 4 Dietary Supplement Capsules because they contain glyburide - a drug that could ... - MedIndia

FDA Warns Consumers About Liqiang 4 Capsules  Jul 13, 2005
An FDA statement said the product, sold as part of a shrink-wrapped two-bottle set, contains glyburide. Glyburide, which is used ... - Epoch Times

SERIOUS WARNING ISSUED BY THE FDA CONCERNING "LIQIANG 4" DUE TO ...  Jul 6, 2005
FDA) has issued an extremely serious warning to consumers not to take Liqiang 4 Dietary Supplement Capsules because they contain glyburide – a drug that ... - Newsinferno.com

FDA Issues Nationwide Alert for "Liqiang 4"  Jul 20, 2005
The US Food and Drug Administration (FDA) is warning consumers not to take Liqiang 4 Dietary Supplement Capsules because they contain glyburide - a drug that ... - Food Consumer

Avandia: decreased HDL cholesterol levels  Jul 17, 2005
A 61-year-old woman with type 2 diabetes, hyperlipidemia, diabetic retinopathy and nephropathy had been taking Fenofibrate, Metformin and Glyburide for more ... - Xagena.it

FDA CAPSULES  Jul 12, 2005
The FDA is warning consumers not to use Liqiang 4 Dietary Supplement Capsules because they contain glyburide, a drug used to lower blood sugar. ... - Newsday

Par Pharmaceutical Reports Second-Quarter Sales and Earnings  Jul 28, 2005
The increased gross margin also results from lower sales of paroxetine HCl, glyburide and metformin HCl tablets, and metformin HCl extended-release tablets. ... - Yahoo News (press release)

Ask the internist: Variety of medications can help with diabetes ...  Jul 19, 2005
TZD. Sulfonylureas (eg glyburide, glipizide, glimepiride, others): These work by causing the pancreas to make more insulin. This ... - Billings Gazette

Dr. Gott: Benefits of Chelation Therapy Exaggerated  Jul 16, 2005
Ask your doctor about this. He can test you by changing your medicine to another compound (glyburide, for example) to see if your skin irritation disappears. ... - RedNova.com <**results**>

Alpharma Receives FDA Approval For Glyburide/Metformin HCL Tablets  Jun 30, 2005
...pharmaceutical company, today announced that the US Food and Drug Administration has granted final approval for the company's ANDA for glyburide/metformin HCl ... - Yahoo News (press release)

Warning issued by FDA over "Liqiang 4 Capsules"  Jul 10, 2005
The FDA has recently issued a warning regarding the consumption of Liqiang 4 Dietary Supplement Capsules because they contain glyburide - a drug that could ... - MedIndia

Chinese supplement could endanger diabetics  Jul 5, 2005
7/5/2005 - The FDA is warning consumers against taking a Chinese dietary supplement called Ligaing 4 because it contains the drug glyburide and could pose life ... - NutraIngredients-usa.com

FDA Issues Nationwide Alert for "Liqiang 4" Due to Potential ...  Jul 5, 2005
The US Food and Drug Administration (FDA) is warning consumers not to take Liqiang 4 Dietary Supplement Capsules because they contain glyburide – a drug that ... - Community Dispatch (press release)

SERIOUS WARNING ISSUED BY THE FDA CONCERNING "LIQIANG 4" DUE TO ...  Jul 6, 2005
FDA) has issued an extremely serious warning to consumers not to take Liqiang 4 Dietary Supplement Capsules because they contain glyburide – a drug that ... - Newsinferno.com

FDA Warns of Dangers of Liqiang 4 Dietary Supplement  Jul 5, 2005
ROCKVILLE, Md., July 5.-The FDA warned today that Liqiang 4 Dietary Supplement Capsules contain glyburide, a drug the agency says could have serious, life ... - MedPage Today

Chinese Supplement a Risk to Diabetics: FDA  Jul 2, 2005
Liqiang 4 Dietary Supplement Capsules contain Glyburide, a drug that is used to lower blood sugar, and is safe when used as labeled in FDA-approved medications ... - HealthCentral.com

FDA warns consumers about Liqiang 4 capsules  Jul 1, 2005
An FDA statement said the product, sold as part of a shrink-wrapped two-bottle set, contains glyburide. Glyburide, which is used ... - Reuters AlertNet

Health Highlights: July 3, 2005  Jul 3, 2005
Liqiang 4 Dietary Supplement Capsules contain glyburide, a drug that is used to lower blood sugar, and is safe when used as labeled in FDA-approved medications ... - RedNova.com

Around Washington  Jul 1, 2005
An FDA statement said the product, sold as part of a shrink-wrapped two-bottle set, contains glyburide. Glyburide, which is used ... - Houston Chronicle

Type 2 diabetes, Avandia may reduce blood pressure  Jun 12, 2005
Following a minimum of four weeks treatment with Metformin, 389 participants were randomized to the add-on treatment with Rosiglitazone or Glyburide for eight ... - Xagena.it

New Data Show Avandia(R) (Rosiglitazone Maleate) May Reduce Blood ...  Jun 11, 2005
Following a minimum of four weeks treatment with metformin, 389 participants were randomized to the add-on treatment with Avandia or glyburide for eight ... - RedNova.com

Top 10 Things to Know About Diabetes Pills  Jul 4, 2005
Sulfonylureas of the second generation are glipizide (brand names Glucotrol and Glucotrol XL), glyburide (Micronase, Glynase, and Diabeta), and glimepiride ... - About Diabetes

FDA Warns Against Supplement  Jul 1, 2005
The Liqiang 4 capsules contain the drug glyburide, an effective diabetes medicine when properly prescribed, the Food and Drug Administration said Friday. ... - Washington Post

PEOPLE'S PHARMACY 100,000 Americans die each year due to medical ...  Jun 12, 2005
In one classic case, a 67-year-old woman was mistakenly dispensed the diabetes drug glyburide instead of her blood-pressure medicine metoprolol. ... - Houston Chronicle,

Dosage Forms Oral tablets
Drug_Category Hypoglycemic Agents; Antiarrhythmic Agents; Sulfonylureas; ATC:A10BB
Absorption Significant absorption within 1 hour and peak plasma levels are reached within 4 hours
Interactions -->Interactions for Glyburide:

The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving MICRONASE, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving MICRONASE, the patient should be observed closely for loss of control.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phe-nothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimet-ics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving MICRONASE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving MICRONASE, the patient should be observed closely for hypoglycemia.

A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide. The mechanism for this interaction is not known.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical or vaginal preparations of miconazole is not known. Metformin: In a single-dose interaction study in NIDDM subjects, decreases in glyburide AUC and Cmax were observed, but were highly variable. The single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmaco-dynamic effects, makes the clinical significance of this interaction uncertain. Coadministration of gly-buride and metformin did not result in any changes in either metformin pharmacokinetics or pharmaco-dynamics.

Toxicity hypoglycemia, LD50=
Organisms Affected Humans and other mammals
Chemical IUPAC Name 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide
Chemical Formula C23H28ClN3O5S
Molecular Weight 494.004 g/mol
Smiles String COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Melting Point 169-170°C
Water Solubility 4 mg/L
State white, crystalline compound
LogP/Hphobicity 4.85
Isoelectric Point Not Available
Biotransformation Primarily hepatic. The major metabolite of glyburide is the 4-trans-hydroxy derivative. A second metabolite, the 3-cis-hydroxy derivative, also occurs
Half Life 10 hours
Protein Binding [%] Extensively bound to serum proteins
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Glyburide.html
http://www.rxlist.com/cgi/generic2/glucovance.htm
Drug Type Approved Drug
Accession No APRD00233
CAS Registry Number 10238-21-8
KEGG Compound ID C07022
PubChem ID SID:167865
PharmGKB ID PA449782
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2248008

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