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Glucagon recombinant
drug data and news
Glucagon recombinant drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Glucagon recombinant
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| Brand Names/Synonyms |
Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide;GRPP; Oxyntomodulin;OXY;OXM; Glucagon; Glucagon-like peptide 1;GLP-1; Glucagon-like peptide 1(7-37);GLP-1(7-37); Glucagon-like peptide 1(7-36);GLP-1(7-36); Glucagon-like peptide 2;GLP-2];Fragment; Glucagon (Eli Lilly); GlucaGen (Novo Nordisk) |
| Indication |
For treatment of severe hypoglycemia, also used in gastrointestinal imaging |
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Description |
29 residue peptide hormone. Glucagon is synthesized in a special non- pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for glucagons |
| Pharmacology |
Used in the treatment of hypoglycemia and in gastric imaging, glucagon increases blood glucose concentration and is used in the treatment of hypoglycemia. Glucagon acts only on liver glycogen, converting it to glucose through the release of insulin. It also relaxes the smooth muscles of the gastrointestinal tract. |
| Mechanism Of Action |
Glucagon binds the glucagon receptor which then initiates a dual signaling pathway using both adenylate cyclase activation and increased intracellular calcium. Glucagon receptors are found in the liver, kidney, brain and pancreatic islet cells. The glucagon mediated signals lead to an increase in insulin excretion |
Glucagon recombinant News
(When available) |
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| Dosage Forms |
KIT;POWDER FOR SOLUTION |
| Drug_Category |
Antihypoglycemic Agents; glycogenolytic agents (68:22.12) |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Human Glucagon |
| Chemical Formula |
C165H249N49O51S1 |
| Molecular Weight |
3767.1 |
| Smiles String |
Not Available |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-1.197 |
| Isoelectric Point |
9.52 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.rxlist.com/cgi/generic2/gluca.htm |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00057 |
| CAS Registry Number |
9007-92-5 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
Not Available |
| SwissProt ID |
GLUC_SHEEP (Q8MJ25) |
| GenBank ID |
AF529185 |
| Drug ID Number [DIN] |
2243297
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