Gemfibrozil drug data and news

Gemfibrozil drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Gemfibrozil

Brand Names/Synonyms

Apo-Gemfibrozil; Ausgem; Bolutol; Brozil; CCRIS 318; CHEMBANK796; CI 719; CI-719; Cholespid; Clearol; Decrelip; Elmogan; Fetinor; Fibratol; Fibrocit; GFZ; Gem-S; Gemd; Gemfibril; Gemfibromax; Gemfibrozil; Gemfibrozil [Usan:Ban:Inn]; Gemfibrozilo [Inn-Spanish]; Gemfibrozilum [Inn-Latin]; Gemlipid; Gemnpid; Gen-Fibro; Genlip; Gevilon; Gevilon Uno; Gozid; Hidil; Hipolixan; Innogen; Ipolipid; Jezil; Lanaterom; Lifibron; Lipazil; Lipigem; Lipira; Lipizyl; Lipozid; Lipur; Litarek; Lopid; Low-Lip; Micolip; Normolip; Novo-Gemfibrozil; Nu-Gemfibrozil; Pilder; Po-Gemfibrozil; Polyxit; Progemzal; Reducel; Regulip; Renabrazin; Sinelip; Synbrozil; TEVA-A; Taborcil; Tentroc; Trialmin; Uno; Wl-Gemfibrozil; [Usan:Ban:Inn]

Indication

For treatment of adult patients with very high elevations of serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort

Sponsored links

Description

Not Available

Pharmacology

Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia.

Mechanism Of Action

Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.

Gemfibrozil News
(When available)

The Lowdown on High Triglycerides Feb 14, 2006
...you take niacin. Fibrates, which include gemfibrozil (Lopid) and fenofibrate (Tricor), are an alternative to niacin. They reduce ... - Gilroy Dispatch (subscription),

Statins may not affect CD4 cell count responses to HIV treatment ... Feb 1, 2006
...they prescribed the 103 patients (39%) with raised triglyceride levels either bezafibrate (Bezalip), fenofibrate (Lipantil) or gemfibrozil (Lopid), while the ... - Aidsmap,

Traces of Prescription Drugs Found in Southland Aquifers Jan 30, 2006
In waste that had undergone treatment, the antibiotic sulfamethoxazole and anti-cholesterol medication gemfibrozil were found at fairly high levels of around ... - Los Angeles Times,

Prescription drug traces found in recycled Los Angeles-area water Jan 30, 2006
The antibiotic sulfamethoxazole and anti-cholesterol medication gemfibrozil were found in treated waste at fairly high levels of around one part per billion. ... - San Jose Mercury News,

'Working poor' join ranks of uninsured Jan 18, 2006
His monthly supply of blood-pressure medicine, Lisinopril, costs $7. He pays $12 for a 30-day supply of cholesterol medication, Gemfibrozil. ... - AZ Central.com,

New weight-loss drug expected soon Jan 9, 2006
...or Tricor. Generic compounds like cholestyramine, gemfibrozil and niacin offer cost-effective cholesterol control. The nutrient ... - Charlotte Observer,

Merck/Schering-Plough Announces Update for the IMPROVE-IT Trial Nov 15, 2005
Gemfibrozil: In a study of twelve healthy adult males, concomitant administration of gemfibrozil (600 mg twice daily) significantly increased the oral ... - Business Wire (press release),

Kos Reports on New Research Presented at AHA: Raising HDL-C or '' ... Nov 15, 2005
NEJM 2001;345:1583-92 (7) Robins, SJ, Collins D, et al. Relation of Gemfibrozil Treatment and Lipid Levels With Major Coronary Events. ... - Business Wire (press release),

New Data Examines Effects of CRESTOR(R) Alone or in Combination ... Nov 15, 2005
...risks of this combination. Combination therapy with rosuvastatin and gemfibrozil should generally be avoided. CRESTOR should be ... - Finanzen.net,

No good evidence that cholesterol drugs lower melanoma risk Nov 10, 2005
The drugs used in various doses in the 16 studies were lovastatin, pravastatin, simvastatin, bezafibrate, clofibrate and gemfibrozil. ... - Dominican Today,

Muraglitazar increases the risk for morbidity and mortality in ... Oct 23, 2005
...have been introduced. Examples of PPAR-alpha agents include the fibric acid derivatives Fenofibrate and Gemfibrozil. These agents ... - Xagena.it,

Drug Treatments: Making the Right Choice Sep 24, 2005
Available drugs that can raise HDL either tend to cause unpleasant side effects (eg, niacin) or do not really raise HDL very much (eg, gemfibrozil, or Lopid). ... - Newsweek

Anorectics on Trial: A Half Century of Federal Regulation of ... Sep 6, 2005
P, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment ... - Annals of Internal Medicine

VNA Health Care Receives $50,000 Donation Through the CRESTOR(R) ... Aug 27, 2005
...risks of this combination. Combination therapy with rosuvastatin and gemfibrozil should generally be avoided. CRESTOR should be ... - PR Newswire (press release),

Omega-3 fatty acids better than statins in reducing death Aug 11, 2005
Fibrates are a group of cholesterol-moderating drugs in use since the early 1960s that includes clofibrate (Atromid), gemfibrozil (Lopid), and fenofibrate ... - Health Sentinel

Genesys Regional Medical Center Receives $50,000 Donation Through ... Jul 30, 2005
...risks of this combination. Combination therapy with rosuvastatin and gemfibrozil should generally be avoided. CRESTOR should be ... - FinanzNachrichten.de

Advisory - Health Canada advises consumers about important safety ... Jul 12, 2005
...regularly drink three or more alcoholic drinks daily; - are taking other cholesterol lowering medication such as fibrates (gemfibrozil, fenofibrate) or niacin ... - Canada NewsWire (press release) <**results**>

Nicotinic Acid in the Management of Dyslipidaemia Associated With ... Jun 11, 2005
Analysis of data from VA-HIT showed that the reduction in coronary events with gemfibrozil was greater in patients with insulin resistance (both diabetic and ... - RedNova.com

Emphasis Switches To Good Cholesterol Jul 5, 2005
...triglycerides. The fibrates, including gemfibrozil (Lopid) and fenofibrate (Tricor and Lofibra), raise HDL by 10 percent to 15 percent. ... - The Ledger

Insights on cholesterol may save more lives Jul 4, 2005
...triglycerides. The fibrates, including gemfibrozil (Lopid) and fenofibrate (Tricor and Lofibra), raise HDL by 10 percent to 15 percent. - Charlotte Observer

World Congress on the Insulin Resistance Syndrome Jun 13, 2005
Analyzing the mechanism of gemfibrozil's benefit in the prevention of atherosclerosis in the Veterans' Administration HDL Intervention Trial, Sander Robins, MD ... - Medscape (subscription)

Let's Protect Others from Life-threatening Diseases Jun 17, 2005
It was later discovered that this drug damages muscles and sometimes can be fatal when used with another drug named Gemfibrozil. ... - AllAfrica.com,

FDA Safety Labeling Changes: Crestor, Diamox Sequels, Femring Jun 8, 2005
...with fibrates or niacin. Combination therapy with rosuvastatin and gemfibrozil generally should be avoided. The risk of myopathy ... - Medscape (subscription)

New Study on Effects of Crestor on Carotid Atherosclerosis ... Apr 25, 2005
...risks of this combination. Combination therapy with rosuvastatin and gemfibrozil should generally be avoided. CRESTOR should be ... - Medical News Today

Public Citizen: Statin-Associated Rhabdomyolysis Apr 6, 2005
1. Chang JT, Staffa JA, Parks M, Green L. Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy. ... - PharmaLive.com

Taking liver-taxing drugs calls for periodic testing Apr 5, 2005
Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), flutamide (Eulexin), fluvastatin (Lescol), gemfibrozil (Lopid), gemtuzumab ... - Contra Costa Times,

Study Showed VYTORIN-TM- -ezetimibe/simvastatin- Superior to ... Mar 8, 2005
Gemfibrozil: In a study of twelve healthy adult males, concomitant administration of gemfibrozil (600 mg twice daily) significantly increased the oral ... - Business Wire (press release),

Public Advisory - Health Canada Endorsed Important Safety ... Mar 11, 2005
...muscle pain or muscle weakness while using a "statin" drug - Taking other cholesterol-lowering medication such as fibrates (gemfibrozil, fenofibrate) or niacin ... - Canada NewsWire (press release),

‘Good’ cholesterol boost helps arteries Mar 13, 2005
The latest: This study randomly assigned 143 retirees with low HDL levels and narrowed arteries to take a combination of gemfibrozil, niacin and cholestyramine ... - Nashua Telegraph,

Astrazeneca Presents New Data Demonstrating Crestor® Reduced C ... Mar 9, 2005
...risks of this combination. Combination therapy with rosuvastatin and gemfibrozil should generally be avoided. CRESTOR should be ... - Medical News Today,

FDA MedWatch - FDA Public Health Advisory issued for Crestor ... Mar 2, 2005
The maximum recommended dose in the FDA-approved label is limited to 10 mg daily in patients with severe renal impairment or who are also taking gemfibrozil. ... - PharmaLive.com (press release),

Class action spring cleaning on Moran's docket Feb 16, 2005
...claimed the companies deceptively advertised Baycol, a drug to reduce cholesterol, and concealed the danger of taking it with another drug, gemfibrozil. ... - Madison County Record,

Update on Risk Factors for Atherosclerosis: The Role of ... Feb 26, 2005
Fibric acid derivatives (gemfibrozil [Lopid], fenofibrate [Tricor], clofibrate [Abitrate]) are used to decrease triglyceride levels. ... - RedNova.com,

BCBSNC Launches New Prescription Drug Savings Initiative Feb 17, 2005
...generic Paxil) trazodone (generic Desyrel) LIPID-LOWERING AGENTS (Drugs to Treat High Cholesterol) cholestyramine (generic Questran) gemfibrozil (generic Lopid ... - PR Newswire (press release)

Dosage Forms

CAPSULE; TABLET

Drug_Category

Antilipemic Agents; Fribic Acid Derivatives; ATC:C10AB04

Absorption

Well absorbed from GI after oral administration (within 1-2 hours)

Interactions

-->Interactions for Gemfibrozil:
)


Clinical Laboratory
	increased creatine	positive antinuclear
	phosphokinase	antibody
	increased bilirubin
	increased liver
	transaminases (AST
	(SGOT), ALT (SGPT)
	increased alkaline
	phophatase
Hematopoietic	anemia	thrombocytopenia
	leukopenia
	bone marrow hypoplasia
	eosinophilia
Immunologic	angioedema	anaphylaxis
	laryngeal edema	Lupus-like syndrome
	urticaria	vasculitis
Integumentary	exfoliative dermatitis	alopecia
	rash
	dermatitis
	pruritus

Toxicity

Overdoses lead to abdominal cramps, abnormal liver function tests, diarrhea, increased CPK, joint and muscle pain, nausea and vomiting, LD50=3162mg/kg (orally in mice)

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid

Chemical Formula

C15H22O3

Molecular Weight

250.333 g/mol

Smiles String

CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O

Melting Point

61-63°C

Water Solubility

10 mg/mL (in base)

State

Solid

LogP/Hphobicity

4.242

Isoelectric Point

Not Available

Biotransformation

Hepatic

Half Life

1.5 hours

Protein Binding [%]

95%

RxList Link

RXlist

Sponsored links

Drug Reference

http://www.drugs.com/cons/Gemfibrozil.html
http://www.rxlist.com/cgi/generic/gemfib.htm
http://www.pharmgkb.org/views/index.jsp?objId=

Drug Type

Approved Drug

Accession No

APRD00293

CAS Registry Number

25812-30-0

KEGG Compound ID

D00334

PubChem ID

SID:175056

PharmGKB ID

PA449750

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

2241608