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Gallamine Triethiodide
drug data and news
Gallamine Triethiodide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Gallamine Triethiodide
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| Brand Names/Synonyms |
3697 R.P.; Benzcurine Iodide; Benzkurin; CHEMBANK1257; F 2559; Flacedil; Flaxedil; Fourneau 2559; G104; Gallaflex; Gallamin; Gallamin Triethiodide; Gallamine; Gallamine Iodide; Gallamine Triethiiodide; Gallamine Triethiodide; Gallamine Triiodoethylate; Gallamine-3eti; Gallamone Triethiodide; Gallamonum; HL 8583; Miowas G; Parexyl; Pirolakson; Pyrolaxon; RP 3697; Relaxan; Remyolan; Retensin; Sincurarine; Syncurarine; Tricuran; Triiodoethylate de Gallamine |
| Indication |
For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation |
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Description |
Not Available |
| Pharmacology |
Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures. |
| Mechanism Of Action |
It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh. |
Gallamine Triethiodide News
(When available) |
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| Dosage Forms |
LIQUID |
| Drug_Category |
Neuromuscular Nondepolarizing Agents; Nicotinic Antagonists; Skeletal Muscle Relaxants; ATC:M03AC02 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
N-[2-[2,3-bis(2-diethylaminoethoxy)phenoxy]ethyl]-N-ethyl-ethanamine |
| Chemical Formula |
C24H45N3O3 |
| Molecular Weight |
423.633 g/mol |
| Smiles String |
CCN(CC)CCOC1=C(C(=CC=C1)OCCN(CC)CC)OCCN(CC)CC |
| Melting Point |
147.5 °C |
| Water Solubility |
Soluble |
| State |
Solid |
| LogP/Hphobicity |
4.017 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00712 |
| CAS Registry Number |
65-29-2 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:209540 |
| PharmGKB ID |
PA449729 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
1927574
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