Galantamine drug data and news

Galantamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Galantamine
Brand Names/Synonyms Galantamin; Galantamine; Galanthamine; Galanthamine Base; Galanthamine Hydrobromide; Jilkon; Lycoremin; Lycoremine; Reminyl
Indication For the treatment of mild to moderate dementia of the Alzheimer's type.
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Description Not Available
Pharmacology Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Galantamine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Galantamine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Galantamine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that Galantamine alters the course of the underlying dementing process.
Mechanism Of Action Galantamine's proposed mechanism of action involves the increase of the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.
Galantamine News
(When available)

Healthy lifestyle lowers risk of dementia caused by white matter ...  07 Mar 2006
...memory and aging program at Butler Hospital in Providence, RI, said more than half a dozen trials of Alzheimer's drugs - donepezil, galantamine and memantine ... - Canada.com,

Shire plc: Strong 2005 Performance Supports Positive Outlook  Feb 23, 2006
FOSRENOL(R) (lanthanum carbonate) GA-GCB(R) (gene-activated) LODINE (R) (etodolac) MESAVANCE(TM) (mesalamine) REMINYL(R) (galantamine hydrobromide) (UK and ... - PR Newswire (press release),

Alzheimer’s Disease Questions and Answers  Feb 28, 2006
Cognex (tacrine, not commonly used because of its potential side effects), Aricept (donezepil), Exelon (rivastigmine), and Reminyl (galantamine) slow the ... - KPHO Phoenix,

Evotec completes Phase I component for Alzheimer’s drug  Feb 8, 2006
...the global market. Novartis's Exelon and Ortho-McNeil's Razadyne/Reminyl (galantamine) share the remainder. The worldwide Alzheimer's ... - In-PharmaTechnologist.com,

Health Tip: There's No Cure for Alzheimer's  Feb 9, 2006
Drugs such as tacrine (Cognex), donepezil (Aricept), rivastigmine (Exelon), or galantamine (Razadyne) can slow the progression of the disease but cannot stop ... - Forbes

Improving Alzheimer’s treatment  Feb 6, 2006
...development of a class of drugs known as cholinesterase inhibitors, for example, donepezil (Aricept), rivastigmine (Exelon) and galantamine (Razadyne, formerly ... - San Bernardino Sun,

Bilateral chronic subdural haematoma: a reversible cause of ...  Feb 9, 2006
...traumatic lesion. He had a background diagnosis of mild Alzheimer's dementia for which he was being treated with galantamine. He ... - Journal of the Royal Society of Medicine

Drug Side Effects Can Befuddle Elderly  Feb 1, 2006
...into mild cognitive impairment has been to slow the progress to dementia with pro-cholinergic drugs, such as Aricept (donepezil) or Reminyl (galantamine). ... - CNN

Health Tip: There's No Cure for Alzheimer's  09 Feb 2006
Drugs such as tacrine (Cognex), donepezil (Aricept), rivastigmine (Exelon), or galantamine (Razadyne) can slow the progression of the disease but cannot stop ... - Forbes

Evotec completes Phase I component for Alzheimer’s drug  Feb 8, 2006
...the global market. Novartis's Exelon and Ortho-McNeil's Razadyne/Reminyl (galantamine) share the remainder. The worldwide Alzheimer's ... - In-PharmaTechnologist.com,

Improving Alzheimer’s treatment  Feb 6, 2006
...development of a class of drugs known as cholinesterase inhibitors, for example, donepezil (Aricept), rivastigmine (Exelon) and galantamine (Razadyne, formerly ... - San Bernardino Sun,

NICE Consults On Revised First Draft Guidance On The Use Of Drugs ...  Jan 24, 2006
Institute for Health and Clinical Excellence (NICE) is consulting on the revised draft of its review of donepezil, rivastigmine, galantamine and memantine for ... - Medical News Today (press release),

Alzheimer's drugs to be available to NHS patients  Jan 22, 2006
In the draft, NICE accepted that donepezil, rivastigmine, galantamine and memantine - known as cholinesterase inhibitors - could alleviate the symptoms of ... - Independent,

Drug Side Effects Can Befuddle Elderly  Feb 1, 2006
...into mild cognitive impairment has been to slow the progress to dementia with pro-cholinergic drugs, such as Aricept (donepezil) or Reminyl (galantamine). ... - CNN

Alzheimer's and the need for swift treatment  Jan 30, 2006
...s. There are two other drugs that work in the same way as Aricept (donepezil) — Reminyl (galantamine) and Exelon rivastigmine. ... - Times Online,

Veggie-burger blues: Soy slips as cholesterol reducer  Jan 27, 2006
...involved three widely used drugs for the mind-destroying disease: Aricept (generically known as donepezil), Exelon (rivastigmine) and Razadyne (galantamine). ... - Globe and Mail,

NICE (National Institute for Health and Clinical Excellence) ...  Jan 22, 2006
...available on the NHS," says John Freeman, Managing Director of Shire Pharmaceuticals' UK operation, which markets Reminyl(R) and Reminyl XL (galantamine)[2] in ... - PR Newswire (press release),

Alzheimer's Drugs Aricept, Razadyne And Exelon Offer Modest ...  Jan 25, 2006
The Cochrane Database of Systematic Reviews 2006, Issue 1. Loy C, Schneider L. Galantamine for Alzheimer's disease and mild cognitive impairment. ... - Medical News Today (press release),

Guidance rules out early treatment for Alzheimer's  Jan 22, 2006
The new guidance is less restrictive than an earlier version that suggested that three drugs — donezepil (Aricept), galantamine (Reminyl), and rivastigmine ... - Times Online,

Thousands of Scots Alzheimer's sufferers will be denied drugs  Jan 22, 2006
At the moment the drugs donepezil (Aricept), rivastigmine (Exelon) and galantamine (Reminyl) are all available for mild to moderate Alzheimer's on the NHS. ... - Scotsman,

Alzheimer sufferers win £60m drug fight  Jan 21, 2006
Three of the drugs, rivastigmine (brand name Exelon), donepezil (Aricept) and galantamine (Reminyl), cost around £2.50 per day per patient, resulting in an ... - The Observer,

Alzheimer's drugs policy reviewed  Jan 22, 2006
Donepezil, rivastigmine and galantamine would be funded but only when new patients reach a moderate stage of the condition. The ... - BBC News,

UK - New guidance on Alzheimer's drugs  Jan 23, 2006
The appraisal committee's proposals on donepezil, galantamine and rivastigmine would mean patients in the early stages of Alzheimer's would be denied the drugs ... - Monsters and Critics.com,

RCP: Nice guidance is still flawed  Jan 23, 2006
Nice has proposed that donepezil, galantamine and rivastigmine could be prescribed only to people with moderate to severe symptoms of the disease. ... - Politics.co.uk,

Nice reverses Alzheimer's drug decision  Jan 23, 2006
However, the recommendations from the National Institute for Health and Clinical Excellence (Nice) would mean that donepezil, galantamine and rivastigmine ... - Politics.co.uk,

Anger over Alzheimer's drugs ruling  Jan 23, 2006
...guidance published by the National Institute for Health and Clinical Excellence (NICE) recommended that donepezil, rivastigmine and galantamine should only be ... - 4ni.co.uk,

Alzheimer's Society: Nice decision is mixed  Jan 23, 2006
Nice is consulting on recommendations that patients with moderately severe Alzheimer's disease should have access to donepezil, rivastigmine, galantamine. ... - Politics.co.uk,

Nice: Alzheimer's patients will benefit from decision  Jan 23, 2006
Nice recommended that patients with moderately severe Alzheimer's diseases should have access to donepezil, galantamine and rivastigmine on the NHS, but said ... - Politics.co.uk,

Today's issue...Alzheimer's drugs  Jan 23, 2006
The decision signals a U-turn on the watchdog's announcement in March last year that donepezil, rivastigmine, galantamine - which cost £2.50 a day - were not ... - Politics.co.uk,

DEMENTIA sufferers have been given fresh hope after a U-turn by ...  Jan 23, 2006
...condition. But the drugs - donepezil, rivastigmine and galantamine - will only be prescribed to people with moderate symptoms. There ... - Glasgow Daily Record,

NICE (National Institute for Health and Clinical Excellence) ...  Jan 22, 2006
...available on the NHS," says John Freeman, Managing Director of Shire Pharmaceuticals' UK operation, which markets Reminyl® and Reminyl XL (galantamine)[2] in ... - Yahoo! News (press release)

Apathy and Its Treatment in Alzheimer's Disease and Other ...  Dec 5, 2005
A few studies also indicate that galantamine (Razadyne) and rivastigmine (Exelon) may also have beneficial neuropsychiatric effects (Birks et al., 2000). ... - Psychiatric Times,

Medications Used to Treat ADHD  Nov 30, 2005
Dr. Eric Mick [11] reported a double-blind study of galantamine vs placebo in adults (77% men; mean age, 36 years) with ADHD. Galantamine ... - Medscape (subscription)

Cortical Activation During Cholinesterase-Inhibitor Treatment in ...  Nov 13, 2005
Several ChE inhibitors have shown efficacy on cognitive measures in the treatment of AD; these include rivastigmine, 1 tacrine, 2 galantamine, 3 and donepezil. ... - Am J Geriatric Psychiatry (subscription)

Confusion, losing place could be signs of dementia  Nov 20, 2005
The life expectancy of most dementia patients is four to six years. One group includes donepizil, rivastigmine and galantamine. ... - Staunton News Leader,

Cholinesterase inhibitors: in search of cholinergic deficits  Sep 16, 2005
These confirm the findings of the 2001 guidelines that donepezil, rivastigmine and galantamine are effective and safe in the treatment of Alzheimer’s disease ... - Adv Psychiatric Treat (subscription)

Stem Cell Research Essential  Oct 3, 2005
...how to comb his hair and even forgets your name, the disease will progress, and as doctors prescribe various drugs such as tacrine or galantamine to slow down ... - Daily Campus (subscription),

Alzheimer's sufferers hit by further delay in NHS approval for ...  Sep 17, 2005
The drugs - rivastigmine (Exelon), donepezil (Aricept) and galantamine (Reminyl) - cost around £2.50 per day per patient, resulting in an NHS bill of £60 ... - Telegraph.co.uk,

Understanding dementia  Sep 23, 2005
...progression. These are donepezil, rivastigmine, memantine and galantamine. The first three drugs are widely available in India. ... - News Today,

EU funded project develops intelligent device for controlled drug ...  Sep 24, 2005
Among the drugs used for testing the device will be insulin, used to treat diabetes; galantamine, used to treat Alzheimer's disease; and naltrexone, a drug ... - Nanotechwire.com,

COMPANY OF THE YEAR: Johnson & Johnson  Sep 15, 2005
In the central nervous system category, J&J is developing line extensions for Topamax as monotherapy and Razadyne galantamine patch. ... - Med Ad News (subscription),

Dosage Forms CAPSULE, EXTENDED RELEASE
Drug_Category Nootropic Agents; Parasympathomimetics; Parasympathomimetics; ATC:N06DA04
Absorption Not Available
Interactions Not Available
Toxicity LD50=75 mg/kg (rat)
Organisms Affected Humans and other mammals
Chemical IUPAC Name (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Chemical Formula C17H21NO3
Molecular Weight 287.354 g/mol
Smiles String CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O
Melting Point 269-270 oC (HBr salt)
Water Solubility 10 mg/mL (HBr salt)
State Solid
LogP/Hphobicity 2.369
Isoelectric Point Not Available
Biotransformation Not Available
Half Life 7 hours
Protein Binding [%] 18%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Galantamine.html
http://www.rxlist.com/cgi/generic/reminyl.htm
Drug Type Approved Drug
Accession No APRD00206
CAS Registry Number 357-70-0
KEGG Compound ID C08526
PubChem ID SID:10719
PharmGKB ID PA449726
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2266717

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