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Follitropin beta
drug data and news
Follitropin beta drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Follitropin beta | ||
| Brand Names/Synonyms | Follitropin beta chain precursor;Follicle-stimulating hormone beta subunit;FSH-beta;FSH-B; Follistim (Organon) | ||
| Indication | For treatment of female infertility | ||
| Sponsored links | Description | Human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the ï?¡- and ï?¢- subunits. The ï?¡- and ï?¢- subunits have 92 and 111 amino acids | |
| Pharmacology | Used for the treatment of female infertility, Follitropin beta or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Follitropin beta is the primary hormone responsible for follicular recruitment and development. | ||
| Mechanism Of Action | FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells. | ||
| Follitropin beta News (When available) |
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| Dosage Forms | SOLUTION | ||
| Drug_Category | Fertility Agents; gonadotropins (68:18.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human follicle stimulating hormone | ||
| Chemical Formula | C975H1513N267O304S26 >beta chain | ||
| Molecular Weight | 22672.9 | ||
| Smiles String | Not Available | ||
| Melting Point | 55 oC (Forastieri, H., Ingham, K.C. J. Biol. Chem. 257:7976-7981 (1982)) | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.33 | ||
| Isoelectric Point | 7.5 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Follitropin_beta.html http://www.rxlist.com/cgi/generic3/follitrop.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00064 | ||
| CAS Registry Number | 9002-68-0 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | FSHB_HUMAN (P01225) | ||
| GenBank ID | M16647 | ||
| Drug ID Number [DIN] | 2243949 |
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