Fluticasone Propionate drug data and news

Fluticasone Propionate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Fluticasone Propionate
Brand Names/Synonyms Advair Diskus 100/50; Advair Diskus 250/50; Advair Diskus 500/50; Cutivate; Flixonase; Flixotide; Flonase; Flovent; Flovent Diskus 100; Flovent Diskus 250; Flovent Diskus 50; Flovent Hfa; Flunase; Fluticasone Propionate
Indication For the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma
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Description Not Available
Pharmacology Fluticasone Propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.
Mechanism Of Action Binds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB [inhibitory molecule for nuclear factor kappaB1], IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve release of cytosolic phospholipase A2 which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Fluticasone Propionate News
(When available)

CHRB Orders a Review  Mar 4, 2006
She had filled out her report before she actually gave the furosemide (Lasix) injection and the report said the shot had been given at 11:30 am, about four ... - Los Angeles Times,

Race-Day Reckoning  Feb 28, 2006
The administration of furosemide (Salix) or other bleeder medications is the reason veterinarians are allowed into the stall of a horse on race-day. ... - BloodHorse,

Owner requests purse redistribution for Palomar Breeders' Cup  Feb 23, 2006
...the race's $200,000 purse after learning a veterinarian falsified the winner's bleeder medication record after she administered furosemide too close to post ... - Thoroughbred Times,

Lifter Shailaja tests positive  Feb 28, 2006
Pratima Kumari and Sanamacha Chanu had tested positive for a male hormone testosterone and a diuretic furosemide respectively at the Athens Olympics in 2004 to ... - Rediff,

Delaware takes step toward blood gas testing  Feb 24, 2006
Horses not racing on furosemide who have levels in excess of 10.4 and furosemide-treated horses who test higher than 12.4 would be in violation of the rules. ... - Thoroughbred Times,

Veterinarian fined for falsifying bleeder medication report on ...  Feb 22, 2006
Neven's report indicated the mare received her furosemide shot at 11:30 am PST, or about four hours before post time of the race, which started at 3:35 pm ... - Thoroughbred Times,

Myocarditis During Clozapine Treatment  Feb 14, 2006
...address this, the cardiology team began treatment with ramipril (an angiotensin-converting enzyme inhibitor) at 2.5 mg/day, intravenous furosemide (a diuretic ... - Am J Psychiatry (subscription)

Bone Breaking Disease – Osteoporosis  Feb 13, 2006
...are corticosteroids taken for variety of conditions like rheumatic, allergic and respiratory disorders, L-thyroxine a thyroid medicine and furosemide which is ... - Mathaba.Net,

Kentucky Horse Racing Authority Approves Withdrawal Guidelines and ...  Feb 10, 2006
Included in the list of therapeutic drugs are: Furosemide, Phenylbutazone, Flunixin, Ketoprofen, Clenbuterol, DMSO, Diclofenac, Meclofenamic Acid, and Ibuprofen ... - BloodHorse,

Record of sportsmen involved in drugs  Jan 31, 2006
In March 2002, two weightlifters were banned by the Malaysian Weightlifting Federation (MWF) for two years for using the masking agent, furosemide. ... - Malay Mail,

Use Of A Microsponge in Drug Delivery Systems  Feb 6, 2006
J Microencapsul.;1996 ,13(5):575-88. J. Akbug, G. Durmaz, Preparation and evaluation of cross-linked chitosan microspheres containing furosemide, Int. J.Pharm. ... - Pharmaceutical Processing,

Membrane trafficking and the regulation of NKCC2  Feb 9, 2006
A, Welch RC, Vazquez N, Hebert SC, and Gamba G. Alternatively spliced isoform of apical Na + -K + -Cl – cotransporter gene encodes a furosemide-sensitive Na ... - AJP-Renal Physiology

Halozyme Therapeutics and Baxter Release Results From the INFUSE ...  Feb 8, 2006
Precautions for the use of Hylenex consist of incompatibility with furosemide, benzodiazepines and phenytoin, and recommendation for consulting appropriate ... - PharmaLive.com (press release),

Halozyme Therapeutics and Baxter Release Results From the INFUSE ...  09 Feb 2006
Precautions for the use of Hylenex consist of incompatibility with furosemide, benzodiazepines and phenytoin, and recommendation for consulting appropriate ... - PR Newswire (press release),

Use Of A Microsponge in Drug Delivery Systems  Feb 6, 2006
J Microencapsul.;1996 ,13(5):575-88. J. Akbug, G. Durmaz, Preparation and evaluation of cross-linked chitosan microspheres containing furosemide, Int. J.Pharm. ... - Pharmaceutical Processing,

Les conclusions du comité disciplinaire  Jan 14, 2006
...with the anti-doping rules and her own testimony, we are of the view that she has to bear the full responsability of the presence of furosemide in her urine ... - L'express.mu,

Record of sportsmen involved in drugs  Jan 31, 2006
In March 2002, two weightlifters were banned by the Malaysian Weightlifting Federation (MWF) for two years for using the masking agent, furosemide. ... - Malay Mail,

Possible campaign slogan: Woman's place is in the House  Jan 30, 2006
...a hospital stay. For example, did you know that Furosemide is the generic version of Lasix, a blood pressure pill? Thompson is hoping ... - MaineToday.com,

Call for the ambulance  Jan 30, 2006
I stole a quick glance at the bottles of medicine that she held in her hand as she spoke and told the crew, nitroglycerine, furosemide and clonodine, all heart ... - Brattleboro Reformer,

Reduce platelet aggregation, blood clotting, inflammation, nervous ...  Jan 12, 2006
Liquorice together with anti-arhythmic drugs or furosemide (Lasix – a potent diuretic), may cause severe hypokalemia (low potassium levels) leading to ... - Health24.com,

Triple Crown Dilemma  Dec 7, 2005
Without a doubt, permitted raceday use of the pain killer "Bute" (Phenylbutazone) and the anti-bleeding medication "Lasix" (Furosemide) have contributed to the ... - Brisnet.com

Alternative renin regulatory pathways and the NKCC1 isoform  Nov 8, 2005
...of renin secretion by the juxtaglomerular (JG) cells (7). We now appreciate that these diuretics act through inhibition of the (furosemide-sensitive) Na + -K ... - AJP-Renal Physiology

Increased Serum Creatinine More Likely when Nesiritide is Combined ...  Nov 16, 2005
High-dose diuretic use was defined as a maximum daily dose of furosemide 160 mg or greater, bumetanide 4 mg or greater, torsemide 80 mg or greater, metolazone ... - DG News

Keeping the beat  Oct 10, 2005
...holds that depletion of electrolytes, particularly potassium, through dehydration from sweating or excessive use of the diuretic furosemide (Salix) could be a ... - Thoroughbred Times,

Motivator team should say no to drugs  Oct 10, 2005
...trainer by now. In American, though, attitudes are different, at least when it comes to a substance called furosemide. Until recently ... - Guardian Unlimited,

Latest Cycling News for October 10, 2005  Oct 10, 2005
Kachalka (ASTeam FRW/GSTop Girls) has been given a two year suspension by the Ukrainian Cycling Federation after testing positive for furosemide during this ... - Cyclingnews.com

Study Shows How Respiratory Disorder Slows Some Racehorses  Sep 15, 2005
The disorder affects about half of all racehorses in North America, but horses here are often given a diuretic, called furosemide (brand name Salix), in an ... - Science Daily (press release)

Bodybuilder Ward suspended for 2 years for positive test  Oct 7, 2005
The SDTNZ said Ward was advised that the drugs he had tested positive for earlier this year - stanozolol, nandrolone and furosemide - would assist his ... - Stuff.co.nz,

Pathogenesis of Contrast-Induced Nephropathy  Sep 24, 2005
Moreover, blocking of the Na+-K+-2Cl-cotransporter in the medullary thick ascending limb by furosemide would strongly decrease oxygen consumption [3]. However ... - Am J Roentgenology (subscription)

The Expanding Pill  Sep 29, 2005
Its formulation of furosemide, a diuretic used for patients with congestive heart failure, was pulled out of clinical trials in May upon disappointing results. ... - Forbes

Exercise Induced Pulmonary Hemorrhage  Oct 1, 2005
...pulmonary edema. Then, there are questions concerning the effectiveness of furosemide (Lasix). Does it truly reduce bleeding? Some ... - TheHorse.com,

Why drive to cut NHS drugs bill may finish up in court  Sep 11, 2005
In a single year generic amoxycillin went up from 47p to £1.69, and warfarin from 82p to £1.70. The diuretic furosemide went up from 26p to £2.14. ... - Times Online,

Athletics: Three test positive  Sep 19, 2005
Sprinter Azmi Ibrahim was athletics’ biggest name to test positive for using masking agent furosemide during the 1996 Malaysia Games in Kuantan. ... - New Straits Times,

Journal of the American Podiatric Medical Association  Sep 21, 2005
The patient underwent a transfusion with 2 U of packed red blood cells, followed by 20 mg of intravenous furosemide therapy, and was supplemented with iron ... - Journal of the American Podiatric Medical Association

Ebstein's Anomaly  Sep 24, 2005
...regurgitation were found. Initially, the patient had a response to fluid restriction and intravenous furosemide and dobutamine. On the ... - New England Journal of Medicine (subscription),

Many meds don't mix with the sun  Sep 21, 2005
Diuretics: Bendroflumethiazide (Corzide), chlorthalidone (Thalitone), furosemide (Lasix), hy-drochlorothiazide (Microzide), hydroflumethiazide (Diucar-din ... - Pioneer Press,

Dosage Forms METERED-DOSE (AEROSOL)
Drug_Category Anti-allergic Agents; Dermatologic Agents; Bronchodilator Agents; Anti-inflammatory Agents; Adrenergic Agents; ATC:D07AC17; ATC:R01AD08; ATC:R03BA05
Absorption The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier.
Interactions Drug Interactions for Fluticasone Propionate:

No Information Provided.

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name [6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanoate
Chemical Formula C25H31F3O5S
Molecular Weight 500.572 g/mol
Smiles String CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Melting Point 272-273 °C
Water Solubility 0.51 mg/L (insoluble)
State Solid
LogP/Hphobicity 4.068
Isoelectric Point Not Available
Biotransformation Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5-fluoromethyl carbothioate grouping. This transformation occurs in 1 metabolic step to produce the inactive 17-(beta)-carboxylic acid metabolite, the only known metabolite detected in man.
Half Life 10 hours
Protein Binding [%] 91%
RxList Link RXlist
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Drug Reference http://www.rxlist.com/cgi/generic2/cutivate.htm
Drug Type Approved Drug
Accession No APRD00065
CAS Registry Number 80474-14-2
KEGG Compound ID C13171
PubChem ID SID:585235
PharmGKB ID PA449687
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2244293

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