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Fluphenazine
drug data and news
Fluphenazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Fluphenazine | ||
| Brand Names/Synonyms | Anatensol; Apo-Fluphenazine; Elinol; Fluorfenazine; Fluorophenazine; Fluorphenazine; Fluphenazine; Fluphenazine Decanoate; Fluphenazine Hcl; Modecate; Modecate Concentrate; Moditen; Moditen Enanthate; Moditen Hcl; Omca; Pacinol; Permitil; Permitil Concentrate; Perphenazine; Pms Fluphenazine; Prolixin; Prolixin Concentrate; Prolixin Decanoate; Prolixin Enanthate; Prolixine; S 94; SQ 4918; Sevinol; Siqualine; Siqualon; Tensofin; Triflumethazine; Valamina; Vespazine; Yespazine | ||
| Indication | For management of manifestations of psychotic disorders. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. | ||
| Mechanism Of Action | Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. | ||
| Fluphenazine News (When available) |
Risk of Serious Harm and/or Death With Potential IV/SC ... Feb 15, 2006 Reducing Nonadherence: New Formulations of Antipsychotic ... Feb 27, 2006 Sildenafil in the Treatment of Antipsychotic-Induced Erectile ... Mar 2, 2006 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Antipsychotics; Phenothiazines; ATC:N05AB02 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Fluphenazine: No information provided. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol | ||
| Chemical Formula | C22H26F3N3OS | ||
| Molecular Weight | 437.523 g/mol | ||
| Smiles String | C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO | ||
| Melting Point | < 25 °C | ||
| Water Solubility | 31.1 mg/L | ||
| State | Dark brown viscous oil | ||
| LogP/Hphobicity | 4.552 | ||
| Isoelectric Point | 7.9 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Fluphenazine.html http://www.rxlist.com/cgi/generic3/fluphen.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00633 | ||
| CAS Registry Number | 69-23-8 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:149164 | ||
| PharmGKB ID | PA449676 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2244166 |
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