| Generic name |
Flupenthixol
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| Brand Names/Synonyms |
Depixol; Emergil; FLUPENTHIXOL; Fluanxol; Fluanxol Depot; Flupenthixol; Flupenthixole; Flupentixol; Flurentixol; Fluxanxol; Siplaril; Siplarol |
| Indication |
For use in schizophrenia and depression |
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Description |
Not Available |
| Pharmacology |
Flupenthixol is an anxiolytic, antidepressive agent and a mood stabilizer. It inhibits the central monoamine receptors, particularly the dopamine D1 and D2 receptors. Therefore, it increases the amount of serotonin and noradrenaline that control mood and thinking, and improves mood. |
| Mechanism Of Action |
Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS. |
Flupenthixol News
(When available) |
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| Dosage Forms |
TABLET; IM Injection |
| Drug_Category |
Antipsychotics; Thioxanthenes; Dopamine Antagonists |
| Absorption |
Fairly slow and incomplete after oral administration |
| Interactions |
Drug Interactions:
Flupenthixol may interact with some drugs, like:
- Monoamine oxidase inhibitors (MAOI): MAOI could theoretically affect flupenthixol pharmacodynamics
- Arecoline
- Eproxindine
- Ethanol: Flupenthixol and Ethanol cause additive CNS depression
- Tricyclic antidepressants: Flupenthixol increases the effect of Tricyclic antidepressants
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| Toxicity |
LD50=300 mk/kg (Oral in mice); LD50=791 mg/kg (Oral in rats); LD50=87 mk/kg (IV in mice); LD50=37 mg/kg (IV in rats) |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol |
| Chemical Formula |
C23H25F3N2OS |
| Molecular Weight |
434.519 g/mol |
| Smiles String |
C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO |
| Melting Point |
Not Available |
| Water Solubility |
0.000346 mg/ml |
| State |
Solid |
| LogP/Hphobicity |
4.694 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Mainly hepatic |
| Half Life |
19 to 39 hours |
| Protein Binding [%] |
highly bound-plasma proteins, >95% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Flupenthixol.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00388 |
| CAS Registry Number |
2709-56-0 |
| KEGG Compound ID |
C11157 |
| PubChem ID |
SID:332476 |
| PharmGKB ID |
PA10268 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2156016
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