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Fluoxetine
drug data and news
Fluoxetine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Fluoxetine | ||
| Brand Names/Synonyms | Animex-On; Deprex; Eufor; Fluctin; Fluoxeren; Fluoxetina [Inn-Spanish]; Fluoxetina [Spanish]; Fluoxetine; Fluoxetine Hcl; Fluoxetine Hydrochloride; Fluoxetine Hydrochloride: Adofen; Fluoxetinum [Inn-Latin]; Fluval; Fontex; Foxetin; HSDB 6633; Portal; Prozac; Prozac Weekly; Pulvules; Reneuron; Sarafem | ||
| Indication | For the treatment of depression; Obsessive compulsive disorder; Bulimia nervosa | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level. | ||
| Mechanism Of Action | Metabolized to norfluoxetine, fluoxetine is a selective serotonin-reuptake inhibitor (SSRI), it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs. | ||
| Fluoxetine News (When available) |
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| Dosage Forms | CAPSULE; LIQUID; SOLUTION | ||
| Drug_Category | Antidepressants, Second-Generation; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB03 | ||
| Absorption | 72% | ||
| Interactions | Do not take this medicine with thioridizine, or within 5 weeks of taking fluoxetine. Talk to your doctor if you are taking certain antibiotics such as erythromycin, clarithromycin or azithromycin. This medicine should not be taken with MAO inhibitors. Caution should be exercised when taking this medicine certain antibiotics, such as erythromycin, clarithromycin, or azithromycin. This medicine should not be taken with MAO inhibitors. If you think you are taking an MAO inhibitor talk to your doctor or pharmacist. Do not take this medicine with St. John's Wort because of the additive effects of sertonin. This medication should not be taken with MAO inhibitors. Your doctor or pharmacist can give you more information on MAO inhibitors. Wait 5 weeks after stopping escitalopram before starting a non-selective MAO inhibitor. Wait 2 weeks after stopping an MAO inhibitor before starting escitalopram. If you are taking medications for migraines such as Imitrex, talk to your doctor before starting this medicine. If you are taking a tricyclic antidepressant, talk to your doctor before taking this medicine. St. John¡¯s Wort should be avoided while taking this medicine due to the additive effects of serotonin. Tell your doctor if you are taking any of the following drugs: blood thinners (Coumadin) other antidepressants metoprolol antihistamines carbamazepine (Tegretol) cimetidine (Tagamet) estrogens fluoxetine (Prozac) intraconazole (Sporanox) ketoconazole (Nizoral) levodopa lithium muscle relaxants birth control pills sleeping pills thyroid medications | ||
| Toxicity | agitation, restlessness, hypomania, and other signs of CNS excitation, LD50=284mg/kg (orally in mice) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine | ||
| Chemical Formula | C17H18F3NO | ||
| Molecular Weight | 309.326 g/mol | ||
| Smiles String | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F | ||
| Melting Point | 179-182°C | ||
| Water Solubility | 50 mg/mL at 25°C | ||
| State | white to off-white crystalline solid | ||
| LogP/Hphobicity | 5.37 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic | ||
| Half Life | 1 to 3 days | ||
| Protein Binding [%] | 94.50% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Fluoxetine.html http://www.rxlist.com/cgi/generic/fluoxetine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00530 | ||
| CAS Registry Number | 54910-89-3 | ||
| KEGG Compound ID | C07990 | ||
| PubChem ID | SID:181999 | ||
| PharmGKB ID | PA449673 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2242124 |
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