Fludrocortisone drug data and news

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An Update on Septic Shock  Feb 16, 2006
Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. ... - Medscape (subscription)

Research Provides More Evidence That Chronic Fatigue Syndrome Is A ...  Jan 9, 2006
Researchers Question Drug For Chronic Fatigue Syndrome (January 4, 2001) -- Fludrocortisone, a drug prescribed to treat low blood pressure, has little or no ... - Science Daily (press release)

It Is Time to "SALVAGE" Patients with Severe Sepsis  Sep 23, 2005
Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. ... - AEM (subscription)

Establishing a Comprehensive, Evidence-based Protocol for the Care ...  Sep 1, 2005
Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. ... - AEM (subscription)

Drug treatment mimics circadian rhythms  Jul 25, 2005
Current therapies, such as Pfizer’s Cortef (hydrocortisone) and Bristol-Myers Squibb’s Florinef (fludrocortisone acetate), cannot adequately control the ... - in-PharmaTechnologist <**results**>

Adrenal-gland failure can cause a blood-pressure drop  Jun 23, 2005
Cortisone is one drug that's part of the program. The other hormone, fludrocortisone, corrects body chemistry and keeps blood pressure in the normal range. ... - Yuma Sun,

Salt and Fludrocortisone Not Effective for Recurrent Syncope  Jun 1, 2005
Source: Salim MA, Di Sessa TG. Effectiveness of fludrocortisone and salt in preventing syncope recurrence in children. A double-blind ... - AAP Grand Rounds (subscription)

Adrenal-gland failure can cause blood-pressure drop  Jun 24, 2005
Cortisone is one drug that's part of the program. The other hormone, fludrocortisone, corrects body chemistry and keeps blood pressure in the normal range. ... - NorthJersey.com,

CME Questions  Jun 1, 2005
...surgery. Assess the utility of treatment with salt and fludrocortisone in prevention of autonomically-mediated syncope. Compare ... - AAP Grand Rounds (subscription)

King Pharmaceuticals Reports First-Quarter 2005 Financial Results  May 9, 2005
...on disposal of certain women's healthcare products; and ii) an intangible asset impairment charge primarily related to Florinef(R) (fludrocortisone acetate, USP ... - PR Newswire

Chronic Fatigue Patients Show Lower Response To Placebos  Mar 22, 2005
Researchers Question Drug For Chronic Fatigue Syndrome (January 4, 2001) -- Fludrocortisone, a drug prescribed to treat low blood pressure, has little or no ... - Science Daily (press release)

King Pharmaceuticals Reports Fourth-Quarter and Year-End 2004 ...  Mar 17, 2005
...and Puerto Rico of Elan on June 12, 2003 and Meridian on January 8, 2003, and an intangible asset impairment charge for Florinef(R) (fludrocortisone acetate). ... - PR Newswire (press release)

Journal Scan  Mar 15, 2005
Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. ... - Medscape (subscription)

When administered concurrently, the following drugs may interact with adrenal corticosteroids.

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)óenhanced hypokalemia. Check serum potassium levels at frequent intervals; use potassium supplements if necessary .

Digitalis glycosidesóenhanced possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Monitor serum potassium levels; use potassium supplements if necessary.

Oral anticoagulantsódecreased prothrombin time response. Monitor prothrombin levels and adjust anticoagulant dosage accordingly.

Antidiabetic drugs (oral agents and insulin)ódiminished antidiabetic effect. Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary.

Aspirinóincreased ulcerogenic effect; decreased pharmacologic effect of aspirin. Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. Monitor salicylate levels or the therapeutic effect for which aspirin is given; adjust salicylate dosage accordingly if effect is altered.

Barbiturates, phenytoin, or rifampinóincreased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. Observe the patient for possible diminished effect of steroid and increase the steroid dosage accordingly.

Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)óenhanced tendency toward edema. Use caution when giving these drugs together, especially in patients with hepatic or cardiac disease.

Vaccinesóneurological complications and lack of antibody response .

Estrogenóincreased levels of corticosteroid-binding globulin, thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. When estrogen therapy is initiated, a reduction in corticosteroid dosage may be required, and increased amounts may be required when estrogen is terminated.

Corticosteroids may affect the nitrobluetetrazolium test for bacterial infection and produce false-negative results.